SearcharxivSearch

arXiv subjects

Yuqing Deng

Publications and source records attributed to Yuqing Deng.

3 recordsLinked to original sources

FNH-TTS: Mixture-of-Experts Duration Modeling for Robust Neural Speech Synthesis

Natural and human-like speech depends on the coordination between prosodic timing and acoustic realization: duration modeling shapes rhythmic structure, while waveform generation determines whether that structure is rendered naturally. In natural speech, duration patterns vary across linguistic contexts and speakers, requiring a TTS system both to capture this variability and to faithfully realize it in the waveform. To address these challenges, we propose FNH-TTS, a VITS-based end-to-end system that jointly improves duration modeling and waveform generation. A mixture-of-experts duration predictor (MoE-DP) uses multiple experts and routing jointly conditioned on linguistic context and speaker information to model diverse duration patterns. For waveform generation, we adopt an inverse short-time Fourier transform (ISTFT)-based generator, providing a more direct and efficient synthesis path. We further employ multi-resolution and sub-band discriminators for fine-grained temporal and spectral adversarial supervision, thereby supporting natural waveform synthesis. Experiments on LJSpeech, VCTK, and LibriTTS show that FNH-TTS achieves the highest mean MOS on LJSpeech and VCTK and the highest duration-category accuracy on LibriTTS among the compared systems, together with competitive waveform reconstruction and substantially faster vocoder inference. Controlled analyses further show that MoE-DP primarily drives the duration-modeling gains, while the vocoder-side components make complementary contributions to synthesis quality and efficiency.

eess.AS

Efficient and Precise Force Field Optimization for Biomolecules Using DPA-2

Molecular simulations are essential tools in computational chemistry, enabling the prediction and understanding of molecular interactions and thermodynamic properties of biomolecules. However, traditional force fields face significant challenges in accurately representing novel molecules and complex chemical environments due to the labor-intensive process of manually setting optimization parameters and the high computational cost of quantum mechanical calculations. To overcome these difficulties, we fine-tuned a high-accuracy DPA-2 pre-trained model and applied it to optimize force field parameters on-the-fly, significantly reducing computational costs. Our method combines this fine-tuned DPA-2 model with a node-embedding-based similarity metric, allowing seamless augmentation to new chemical species without manual intervention. We applied this process to the TYK2 inhibitor and PTP1B systems and demonstrated its effectiveness through the improvement of free energy perturbation calculation results. This advancement contributes valuable insights and tools for the computational chemistry community.

physics.chem-ph

An automated and multi-parametric algorithm for objective analysis of meibography images

Meibography is a non-contact imaging technique used by ophthalmologists to assist in the evaluation and diagnosis of meibomian gland dysfunction (MGD). While artificial qualitative analysis of meibography images could lead to low repeatability and efficiency and multi-parametric analysis is demanding to offer more comprehensive information in discovering subtle changes of meibomian glands during MGD progression, we developed an automated and multi-parametric algorithm for objective and quantitative analysis of meibography images. The full architecture of the algorithm can be divided into three steps: (1) segmentation of the tarsal conjunctiva area as the region of interest (ROI); (2) segmentation and identification of glands within the ROI; and (3) quantitative multi-parametric analysis including newly defined gland diameter deformation index (DI), gland tortuosity index (TI), and glands signal index (SI). To evaluate the performance of the automated algorithm, the similarity index (k) and the segmentation error including the false positive rate (r_P) and the false negative rate (r_N) are calculated between the manually defined ground truth and the automatic segmentations of both the ROI and meibomian glands of 15 typical meibography images. The feasibility of the algorithm is demonstrated in analyzing typical meibograhy images.

eess.IV