Zakia Zainib | Searcharxiv

arXiv2020

Reduced order methods for parametrized non-linear and time dependent optimal flow control problems, towards applications in biomedical and environmental sciences

We introduce reduced order methods as an efficient strategy to solve parametrized non-linear and time dependent optimal flow control problems governed by partial differential equations. Indeed, the optimal control problems require a huge computational effort in order to be solved, most of all in physical and/or geometrical parametrized settings. Reduced order methods are a reliable and suitable approach, increasingly gaining popularity, to achieve rapid and accurate optimal solutions in several fields, such as in biomedical and environmental sciences. In this work, we employ a POD-Galerkin reduction approach over a parametrized optimality system, derived from the Karush-Kuhn-Tucker conditions. The methodology presented is tested on two boundary control problems, governed respectively by (i) time dependent Stokes equations and (ii) steady non-linear Navier-Stokes equations.

math.NA↗

arXiv2019

Reduced order methods for parametric optimal flow control in coronary bypass grafts, towards patient-specific data assimilation

Coronary artery bypass grafts (CABG) surgery is an invasive procedure performed to circumvent partial or complete blood flow blockage in coronary artery disease (CAD). In this work, we apply a numerical optimal flow control model to patient-specific geometries of CABG, reconstructed from clinical images of real-life surgical cases, in parameterized settings. The aim of these applications is to match known physiological data with numerical hemodynamics corresponding to different scenarios, arisen by tuning some parameters. Such applications are an initial step towards matching patient-specific physiological data in patient-specific vascular geometries as best as possible. Two critical challenges that reportedly arise in such problems are, $\left( i \right)$. lack of robust quantification of meaningful boundary conditions required to match known data as best as possible and $\left( ii \right)$. high computational cost. In this work, we utilize unknown control variables in the optimal flow control problems to take care of the first challenge. Moreover, to address the second challenge, we propose a time-efficient and reliable computational environment for such parameterized problems by projecting them onto a low-dimensional solution manifold through proper orthogonal decomposition (POD)--Galerkin.

math.NA↗