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Zan Huang

Publications and source records attributed to Zan Huang.

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GRAFT: Grounded and Efficient Online Reinforcement Adaptation for Fine-Grained Robot Manipulation

Pretrained vision-language-action (VLA) policies provide strong priors for robot manipulation, yet adapting them online to fine-grained biomedical tasks remains challenging. Task success often hinges on subtle, view-dependent visual cues, while task-level rewards provide little guidance about which regions matter, making it difficult to learn task-relevant visual grounding from limited real-robot interaction. Online adaptation is further constrained by the computational cost of VLA inference and replay-based updates. We introduce GRAFT (Grounded Reinforcement Adaptation for Fast Task Learning), a framework for efficient online VLA adaptation through grounded perception. GRAFT uses region-level supervision to learn view-specific visual anchors that focus perception on task-relevant local cues without requiring region proposals at deployment. It further combines single-step action generation with cached visual-language prefix reuse to accelerate online learning. Across four biomedical manipulation tasks, GRAFT improves success rates by 32.5 percentage points under matched adaptation budgets, while reducing the computational overhead of online policy updates.

cs.RO

Conflict and Congruency Effects in Large Language Models: In-Weight and In-Context Competition in a Verbal Conflict Task

Congruency effects, observed in conflict tasks such as Stroop and flanker tasks, have been investigated for nearly a century in psychology and neuroscience, but their mechanistic basis is not fully understood. We introduce a verbal-only LLM conflict task in which a prompt stem elicits a default same-color completion and an explicit rule either agrees with (congruent condition) or conflicts with (incongruent condition) the completion. Gemma-2-2B and six Pythia models ranging from 410M to 12B parameters showed strong default same-color tendencies, and six of seven models showed strong congruency effects. Using causal attribution analysis, attention analysis, and attention ablations, we identified distinct processing pathways in these LLMs: a pathway involving short-range attention to a superficial color cue that is preferentially activated in the congruent condition, and a pathway involving long-range attention to the rule prefix that is preferentially activated in the incongruent condition. Fine-tuning that strengthened the default same-color tendency had divergent effects on task conditions, reducing incongruent performance while increasing congruent performance. In contrast, increasing rule set size selectively impaired incongruent performance. These converging findings support an account in which congruency effects in this task arise from competition between an in-weight default mapping and an in-context rule-based mapping. More broadly, our findings illustrate how LLMs can serve as model systems for mechanistic analysis of competition between default and rule-governed response tendencies within a single learned network.

q-bio.NC

BioMARS: A Multi-Agent Robotic System for Autonomous Biological Experiments

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited adaptability to dynamic lab conditions, inadequate error handling, and high operational complexity. Here we introduce BioMARS (Biological Multi-Agent Robotic System), an intelligent platform that integrates LLMs, VLMs, and modular robotics to autonomously design, plan, and execute biological experiments. BioMARS uses a hierarchical architecture: the Biologist Agent synthesizes protocols via retrieval-augmented generation; the Technician Agent translates them into executable robotic pseudo-code; and the Inspector Agent ensures procedural integrity through multimodal perception and anomaly detection. The system autonomously conducts cell passaging and culture tasks, matching or exceeding manual performance in viability, consistency, and morphological integrity. It also supports context-aware optimization, outperforming conventional strategies in differentiating retinal pigment epithelial cells. A web interface enables real-time human-AI collaboration, while a modular backend allows scalable integration with laboratory hardware. These results highlight the feasibility of generalizable, AI-driven laboratory automation and the transformative role of language-based reasoning in biological research.

cs.RO

Revisiting Self-Attentive Sequential Recommendation

Recommender systems are ubiquitous in on-line services to drive businesses. And many sequential recommender models were deployed in these systems to enhance personalization. The approach of using the transformer decoder as the sequential recommender was proposed years ago and is still a strong baseline in recent works. But this kind of sequential recommender model did not scale up well, compared to language models. Quite some details in the classical self-attentive sequential recommender model could be revisited, and some new experiments may lead to new findings, without changing the general model structure which was the focus of many previous works. In this paper, we show the details and propose new experiment methodologies for future research on sequential recommendation, in hope to motivate further exploration to new findings in this area.

cs.IR

Global Mapping of Gene/Protein Interactions in PubMed Abstracts: A Framework and an Experiment with P53 Interactions

Gene/protein interactions provide critical information for a thorough understanding of cellular processes. Recently, considerable interest and effort has been focused on the construction and analysis of genome-wide gene networks. The large body of biomedical literature is an important source of gene/protein interaction information. Recent advances in text mining tools have made it possible to automatically extract such documented interactions from free-text literature. In this paper, we propose a comprehensive framework for constructing and analyzing large-scale gene functional networks based on the gene/protein interactions extracted from biomedical literature repositories using text mining tools. Our proposed framework consists of analyses of the network topology, network topology-gene function relationship, and temporal network evolution to distill valuable information embedded in the gene functional interactions in literature. We demonstrate the application of the proposed framework using a testbed of P53-related PubMed abstracts, which shows that literature-based P53 networks exhibit small-world and scale-free properties. We also found that high degree genes in the literature-based networks have a high probability of appearing in the manually curated database and genes in the same pathway tend to form local clusters in our literature-based networks. Temporal analysis showed that genes interacting with many other genes tend to be involved in a large number of newly discovered interactions.

q-bio.MN

Revisiting the details when evaluating a visual tracker

Visual tracking algorithms are naturally adopted in various applications, there have been several benchmarks and many tracking algorithms, more expected to appear in the future. In this report, I focus on single object tracking and revisit the details of tracker evaluation based on widely used OTB\cite{otb} benchmark by introducing a simpler, accurate, and extensible method for tracker evaluation and comparison. Experimental results suggest that there may not be an absolute winner among tracking algorithms. We have to perform detailed analysis to select suitable trackers for use cases.

cs.CV