arXiv subjects

Zanxiang He

Publications and source records attributed to Zanxiang He.

2 recordsLinked to original sources

arXiv2026

EndoGov: A knowledge-governed multi-agent expert system for endometrial cancer risk stratification

Multimodal artificial intelligence models for endometrial cancer (EC) risk stratification typically optimize aggregate predictive performance but provide limited mechanisms for enforcing mandatory guideline overrides, such as assigning POLE-mutated tumors to the low-risk group despite high-grade morphology. We present EndoGov, a two-tier multi-agent expert system that factorizes the decision process as D(x) = G(P(x), R), where specialist agents P extract structured evidence and a governance agent G applies an executable rule set R. Tier 1 comprises pathology, molecular, and clinical agents that independently generate schema-constrained reports from frozen foundation-model features or structured records. Tier 2 queries an evidence-level-weighted Guideline Knowledge Graph, using deterministic hard-path rules for high-priority overrides and constrained soft-path reasoning for ambiguous cases. In TCGA-UCEC (n=541), EndoGov achieved 0.943 accuracy, 0.973 macro AUC, and a conditional logic-violation rate (C-LVR) of 0.93% among trigger-exposed cases. In CPTAC-UCEC (n=95), where reference labels are guideline-derived, EndoGov reached 0.842 accuracy compared with < 0.31 for locked-transfer neural baselines, supporting governance-pathway transfer under distribution shift rather than validation against independent clinical truth. End-to-end safety decomposition localized residual failures primarily to upstream molecular detection rather than downstream governance. Backend-swap experiments further showed that hard-path compliance is invariant to the LLM backend. These findings indicate that explicit clinical-rule governance can provide guideline-compliant, auditable EC risk assignment while preserving competitive discrimination.

cs.MA↗

arXiv2025

Mapis: A Knowledge-Graph Grounded Multi-Agent Framework for Evidence-Based PCOS Diagnosis

Polycystic Ovary Syndrome (PCOS) constitutes a significant public health issue affecting 10% of reproductive-aged women, highlighting the critical importance of developing effective diagnostic tools. Previous machine learning and deep learning detection tools are constrained by their reliance on large-scale labeled data and an lack of interpretability. Although multi-agent systems have demonstrated robust capabilities, the potential of such systems for PCOS detection remains largely unexplored. Existing medical multi-agent frameworks are predominantly designed for general medical tasks, suffering from insufficient domain integration and a lack of specific domain knowledge. To address these challenges, we propose Mapis, the first knowledge-grounded multi-agent framework explicitly designed for guideline-based PCOS diagnosis. Specifically, it built upon the 2023 International Guideline into a structured collaborative workflow that simulates the clinical diagnostic process. It decouples complex diagnostic tasks across specialized agents: a gynecological endocrine agent and a radiology agent collaborative to verify inclusion criteria, while an exclusion agent strictly rules out other causes. Furthermore, we construct a comprehensive PCOS knowledge graph to ensure verifiable, evidence-based decision-making. Extensive experiments on public benchmarks and specialized clinical datasets, benchmarking against nine diverse baselines, demonstrate that Mapis significantly outperforms competitive methods. On the clinical dataset, it surpasses traditional machine learning models by 13.56%, single-agent by 6.55%, and previous medical multi-agent systems by 7.05% in Accuracy.

cs.MA↗