Zern Ke | Searcharxiv

arXiv2026

From Cumulative Weights to Marginal Density Ratios: Per-Protocol Estimation in Sequential Target Trial Emulation

Sequential target trial emulation evaluates eligibility at multiple baseline times to emulate a sequence of randomized trials using observational data. Estimating per-protocol effects in this setting is challenging because treatment deviations and loss to follow-up induce selection among individuals who remain observed and adherent over time. Conventional inverse-probability methods address this selection using cumulative weights constructed from estimated adherence and censoring probabilities, but these weights can be highly variable, leading to unstable and imprecise effect estimates. We propose a different approach based on marginal density ratios (MDRs). The MDR directly compares the state distribution among individuals who would remain event-free under a target treatment strategy with the corresponding distribution among observed-adherent individuals. We use longitudinal g-computation to generate the target risk sets and a probabilistic classifier to estimate density ratios for reweighting the observed outcomes. Building on this approach, we also develop a doubly robust extension. Favorable performance across the simulation study suggests that MDR weighting is a promising alternative to cumulative longitudinal weights when its identification assumptions are plausible.

stat.ME↗

arXiv2026

Stochastic weather generators for high-frequency wind vector time series

Surface winds can vary substantially from one minute to the next, so there is scope for studying its variation on this fine time scale. Restricting to the month of June to minimize seasonality, this work develops a range of machine learning models for generating realistic time series of surface wind vectors at a site in Lamont, Oklahoma based on more than 30 years of high quality measurements at the minute time scale. Such a generator could be used as an input into models from a range of disciplines, notably for wind energy, but also wildfire spread and aviation, among others. The data show complex diurnal structures in both wind speed and direction that would be challenging to capture with standard time series models, so we consider a number of machine learning approaches to producing a stochastic wind generator based on time vector-quantized variational autoencoders. We consider generating a day's worth of data at a time and generating a day of wind vectors conditional on the previous day's winds. We also study methods for incorporating a discrete weather state variable in the generator. We evaluate the generators using a wide range of formal and informal methods. The best of these generators can capture many but not all of the complex features present in the observational data. In particular, the best of our approaches accurately mimic diurnal changes in wind volatility but struggle to match the observed distribution of extreme wind speeds.

stat.AP↗