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Zhan Qu

Publications and source records attributed to Zhan Qu.

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Risk Horizons: Structured Hypothesis Spaces for Longitudinal Clinical Prediction

Predicting future clinical events from longitudinal electronic health records (EHRs) requires selecting plausible outcomes from a large and structured event space under sparse observations. While clinical coding systems provide hierarchical organization of events, cross-modal and temporal relationships are not explicitly specified and must instead be inferred from data, making prediction difficult for weakly observed longitudinal transitions. We introduce Risk Horizons, a geometry-aware framework for constructing patient-specific candidate spaces for multi-modal next-visit prediction. Risk Horizons combines deterministic coding hierarchies with data-driven lagged cross-modal associations, embeds the resulting clinical graph in hyperbolic space, and retrieves candidate futures using directional risk cones. This reframes longitudinal prediction as ranking within a compact, clinically coherent hypothesis space rather than scoring an unconstrained vocabulary. Experiments on MIMIC-IV and eICU demonstrate competitive next-visit prediction performance, with consistently improved hierarchy consistency across diagnoses, procedures, and medications. Further analysis suggests that hyperbolic structured candidate retrieval is the primary driver of performance, while LLMs are effective as constrained inference-time rerankers operating over clinically grounded candidate sets.

cs.LG

Vital Trace: Protocol-Constrained Patient-State Reasoning for Longitudinal Clinical Trajectories

Longitudinal clinical reasoning over electronic health records requires tracking evolving physiological measurements, laboratory results, and interventions across extended patient trajectories. Existing LLM-based clinical reasoning systems often rely on repeatedly serializing patient histories or exchanging unconstrained textual agent messages, leading to context drift, unstable reasoning, and growing inference cost over long horizons. We present Vital Trace, a protocol-constrained multi-agent framework for future clinical risk prediction over evolving ICU trajectories. Instead of maintaining unbounded textual histories, Vital Trace uses a compact persistent patient-state memory together with staged reasoning performed by four coordinated agents: a Router, Reasoner, Auditor, and Steward. To support temporally coherent reasoning, we introduce a manually curated Global Protocol containing physiological state-transition rules and a dynamic patient-state representation that tracks hemodynamic, respiratory, renal, metabolic, and inflammatory instability over time. We evaluate Vital Trace on MIMIC-IV and eICU using future vasopressor-support, respiratory-support, renal-support, and deterioration prediction tasks. Results show that structured protocol-constrained reasoning improves temporal consistency, communication stability, calibration, and interpretability compared with free-form multi-agent baselines while achieving strong predictive performance across long ICU trajectories.

cs.LG

X-VORTEX: Spatio-Temporal Contrastive Learning for Wake Vortex Trajectory Forecasting

Wake vortices are strong, coherent air turbulences created by aircraft, and they pose a major safety and capacity challenge for air traffic management. Tracking how vortices move, weaken, and dissipate over time from LiDAR measurements is still difficult because scans are sparse, vortex signatures fade as the flow breaks down under atmospheric turbulence and instabilities, and point-wise annotation is prohibitively expensive. Existing approaches largely treat each scan as an independent, fully supervised segmentation problem, which overlooks temporal structure and does not scale to the vast unlabeled archives collected in practice. We present X-VORTEX, a spatio-temporal contrastive learning framework grounded in Augmentation Overlap Theory that learns physics-aware representations from unlabeled LiDAR point cloud sequences. X-VORTEX addresses two core challenges: sensor sparsity and time-varying vortex dynamics. It constructs paired inputs from the same underlying flight event by combining a weakly perturbed sequence with a strongly augmented counterpart produced via temporal subsampling and spatial masking, encouraging the model to align representations across missing frames and partial observations. Architecturally, a time-distributed geometric encoder extracts per-scan features and a sequential aggregator models the evolving vortex state across variable-length sequences. We evaluate on a real-world dataset of over one million LiDAR scans. X-VORTEX achieves superior vortex center localization while using only 1% of the labeled data required by supervised baselines, and the learned representations support accurate trajectory forecasting.

cs.LG

MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs

Large Language Models (LLMs) are increasingly applied to medicine, yet their adoption is limited by concerns over reliability and safety. Existing evaluations either test factual medical knowledge in isolation or assess patient-level reasoning without verifying correctness, leaving a critical gap. We introduce MediEval, a benchmark that links MIMIC-IV electronic health records (EHRs) to a unified knowledge base built from UMLS and other biomedical vocabularies. MediEval generates diverse factual and counterfactual medical statements within real patient contexts, enabling systematic evaluation across a 4-quadrant framework that jointly considers knowledge grounding and contextual consistency. Using this framework, we identify critical failure modes, including hallucinated support and truth inversion, that current proprietary, open-source, and domain-specific LLMs frequently exhibit. To address these risks, we propose Counterfactual Risk-Aware Fine-tuning (CoRFu), a DPO-based method with an asymmetric penalty targeting unsafe confusions. CoRFu improves by +16.4 macro-F1 points over the base model and eliminates truth inversion errors, demonstrating both higher accuracy and substantially greater safety.

cs.CL

WPT: World-to-Policy Transfer via Online World Model Distillation

Recent years have witnessed remarkable progress in world models, which primarily aim to capture the spatio-temporal correlations between an agent's actions and the evolving environment. However, existing approaches often suffer from tight runtime coupling or depend on offline reward signals, resulting in substantial inference overhead or hindering end-to-end optimization. To overcome these limitations, we introduce WPT, a World-to-Policy Transfer training paradigm that enables online distillation under the guidance of an end-to-end world model. Specifically, we develop a trainable reward model that infuses world knowledge into a teacher policy by aligning candidate trajectories with the future dynamics predicted by the world model. Subsequently, we propose policy distillation and world reward distillation to transfer the teacher's reasoning ability into a lightweight student policy, enhancing planning performance while preserving real-time deployability. Extensive experiments on both open-loop and closed-loop benchmarks show that our WPT achieves state-of-the-art performance with a simple policy architecture: it attains a 0.11 collision rate (open-loop) and achieves a 79.23 driving score (closed-loop) surpassing both world-model-based and imitation-learning methods in accuracy and safety. Moreover, the student sustains up to 4.9x faster inference, while retaining most of the gains.

cs.CV

Prioritizing Perception-Guided Self-Supervision: A New Paradigm for Causal Modeling in End-to-End Autonomous Driving

End-to-end autonomous driving systems, predominantly trained through imitation learning, have demonstrated considerable effectiveness in leveraging large-scale expert driving data. Despite their success in open-loop evaluations, these systems often exhibit significant performance degradation in closed-loop scenarios due to causal confusion. This confusion is fundamentally exacerbated by the overreliance of the imitation learning paradigm on expert trajectories, which often contain unattributable noise and interfere with the modeling of causal relationships between environmental contexts and appropriate driving actions. To address this fundamental limitation, we propose Perception-Guided Self-Supervision (PGS) - a simple yet effective training paradigm that leverages perception outputs as the primary supervisory signals, explicitly modeling causal relationships in decision-making. The proposed framework aligns both the inputs and outputs of the decision-making module with perception results, such as lane centerlines and the predicted motions of surrounding agents, by introducing positive and negative self-supervision for the ego trajectory. This alignment is specifically designed to mitigate causal confusion arising from the inherent noise in expert trajectories. Equipped with perception-driven supervision, our method, built on a standard end-to-end architecture, achieves a Driving Score of 78.08 and a mean success rate of 48.64% on the challenging closed-loop Bench2Drive benchmark, significantly outperforming existing state-of-the-art methods, including those employing more complex network architectures and inference pipelines. These results underscore the effectiveness and robustness of the proposed PGS framework and point to a promising direction for addressing causal confusion and enhancing real-world generalization in autonomous driving.

cs.RO

From Monolingual to Bilingual: Investigating Language Conditioning in Large Language Models for Psycholinguistic Tasks

Large Language Models (LLMs) exhibit strong linguistic capabilities, but little is known about how they encode psycholinguistic knowledge across languages. We investigate whether and how LLMs exhibit human-like psycholinguistic responses under different linguistic identities using two tasks: sound symbolism and word valence. We evaluate two models, Llama-3.3-70B-Instruct and Qwen2.5-72B-Instruct, under monolingual and bilingual prompting in English, Dutch, and Chinese. Behaviorally, both models adjust their outputs based on prompted language identity, with Qwen showing greater sensitivity and sharper distinctions between Dutch and Chinese. Probing analysis reveals that psycholinguistic signals become more decodable in deeper layers, with Chinese prompts yielding stronger and more stable valence representations than Dutch. Our results demonstrate that language identity conditions both output behavior and internal representations in LLMs, providing new insights into their application as models of cross-linguistic cognition.

cs.CL

PoeTone: A Framework for Constrained Generation of Structured Chinese Songci with LLMs

This paper presents a systematic investigation into the constrained generation capabilities of large language models (LLMs) in producing Songci, a classical Chinese poetry form characterized by strict structural, tonal, and rhyme constraints defined by Cipai templates. We first develop a comprehensive, multi-faceted evaluation framework that includes: (i) a formal conformity score, (ii) automated quality assessment using LLMs, (iii) human evaluation, and (iv) classification-based probing tasks. Using this framework, we evaluate the generative performance of 18 LLMs, including 3 proprietary models and 15 open-source models across 4 families, under five prompting strategies: zero-shot, one-shot, completion-based, instruction-based, and chain-of-thought. Finally, we propose a Generate-Critic architecture in which the evaluation framework functions as an automated critic. Leveraging the critic's feedback as a scoring function for best-of-N selection, we fine-tune 3 lightweight open-source LLMs via supervised fine-tuning (SFT), resulting in improvements of up to 5.88% in formal conformity. Our findings offer new insights into the generative strengths and limitations of LLMs in producing culturally significant and formally constrained literary texts.

cs.CL

Explainable LiDAR 3D Point Cloud Segmentation and Clustering for Detecting Airplane-Generated Wind Turbulence

Wake vortices - strong, coherent air turbulences created by aircraft - pose a significant risk to aviation safety and therefore require accurate and reliable detection methods. In this paper, we present an advanced, explainable machine learning method that utilizes Light Detection and Ranging (LiDAR) data for effective wake vortex detection. Our method leverages a dynamic graph CNN (DGCNN) with semantic segmentation to partition a 3D LiDAR point cloud into meaningful segments. Further refinement is achieved through clustering techniques. A novel feature of our research is the use of a perturbation-based explanation technique, which clarifies the model's decision-making processes for air traffic regulators and controllers, increasing transparency and building trust. Our experimental results, based on measured and simulated LiDAR scans compared against four baseline methods, underscore the effectiveness and reliability of our approach. This combination of semantic segmentation and clustering for real-time wake vortex tracking significantly advances aviation safety measures, ensuring that these are both effective and comprehensible.

cs.CV

Can Hallucinations Help? Boosting LLMs for Drug Discovery

Hallucinations in large language models (LLMs), plausible but factually inaccurate text, are often viewed as undesirable. However, recent work suggests that such outputs may hold creative potential. In this paper, we investigate whether hallucinations can improve LLMs on molecule property prediction, a key task in early-stage drug discovery. We prompt LLMs to generate natural language descriptions from molecular SMILES strings and incorporate these often hallucinated descriptions into downstream classification tasks. Evaluating seven instruction-tuned LLMs across five datasets, we find that hallucinations significantly improve predictive accuracy for some models. Notably, Falcon3-Mamba-7B outperforms all baselines when hallucinated text is included, while hallucinations generated by GPT-4o consistently yield the greatest gains between models. We further identify and categorize over 18,000 beneficial hallucinations, with structural misdescriptions emerging as the most impactful type, suggesting that hallucinated statements about molecular structure may increase model confidence. Ablation studies show that larger models benefit more from hallucinations, while temperature has a limited effect. Our findings challenge conventional views of hallucination as purely problematic and suggest new directions for leveraging hallucinations as a useful signal in scientific modeling tasks like drug discovery.

cs.CL

GaussianTalker: Speaker-specific Talking Head Synthesis via 3D Gaussian Splatting

Recent works on audio-driven talking head synthesis using Neural Radiance Fields (NeRF) have achieved impressive results. However, due to inadequate pose and expression control caused by NeRF implicit representation, these methods still have some limitations, such as unsynchronized or unnatural lip movements, and visual jitter and artifacts. In this paper, we propose GaussianTalker, a novel method for audio-driven talking head synthesis based on 3D Gaussian Splatting. With the explicit representation property of 3D Gaussians, intuitive control of the facial motion is achieved by binding Gaussians to 3D facial models. GaussianTalker consists of two modules, Speaker-specific Motion Translator and Dynamic Gaussian Renderer. Speaker-specific Motion Translator achieves accurate lip movements specific to the target speaker through universalized audio feature extraction and customized lip motion generation. Dynamic Gaussian Renderer introduces Speaker-specific BlendShapes to enhance facial detail representation via a latent pose, delivering stable and realistic rendered videos. Extensive experimental results suggest that GaussianTalker outperforms existing state-of-the-art methods in talking head synthesis, delivering precise lip synchronization and exceptional visual quality. Our method achieves rendering speeds of 130 FPS on NVIDIA RTX4090 GPU, significantly exceeding the threshold for real-time rendering performance, and can potentially be deployed on other hardware platforms.

cs.CV

CoDy: Counterfactual Explainers for Dynamic Graphs

Temporal Graph Neural Networks (TGNNs) are widely used to model dynamic systems where relationships and features evolve over time. Although TGNNs demonstrate strong predictive capabilities in these domains, their complex architectures pose significant challenges for explainability. Counterfactual explanation methods provide a promising solution by illustrating how modifications to input graphs can influence model predictions. To address this challenge, we present CoDy, Counterfactual Explainer for Dynamic Graphs, a model-agnostic, instance-level explanation approach that identifies counterfactual subgraphs to interpret TGNN predictions. CoDy employs a search algorithm that combines Monte Carlo Tree Search with heuristic selection policies, efficiently exploring a vast search space of potential explanatory subgraphs by leveraging spatial, temporal, and local event impact information. Extensive experiments against state-of-the-art factual and counterfactual baselines demonstrate CoDy's effectiveness, with improvements of 16% in AUFSC+ over the strongest baseline.

cs.LG

Diversity Matters: Fully Exploiting Depth Clues for Reliable Monocular 3D Object Detection

As an inherently ill-posed problem, depth estimation from single images is the most challenging part of monocular 3D object detection (M3OD). Many existing methods rely on preconceived assumptions to bridge the missing spatial information in monocular images, and predict a sole depth value for every object of interest. However, these assumptions do not always hold in practical applications. To tackle this problem, we propose a depth solving system that fully explores the visual clues from the subtasks in M3OD and generates multiple estimations for the depth of each target. Since the depth estimations rely on different assumptions in essence, they present diverse distributions. Even if some assumptions collapse, the estimations established on the remaining assumptions are still reliable. In addition, we develop a depth selection and combination strategy. This strategy is able to remove abnormal estimations caused by collapsed assumptions, and adaptively combine the remaining estimations into a single one. In this way, our depth solving system becomes more precise and robust. Exploiting the clues from multiple subtasks of M3OD and without introducing any extra information, our method surpasses the current best method by more than 20% relatively on the Moderate level of test split in the KITTI 3D object detection benchmark, while still maintaining real-time efficiency.

cs.CV

Focus on Local: Detecting Lane Marker from Bottom Up via Key Point

Mainstream lane marker detection methods are implemented by predicting the overall structure and deriving parametric curves through post-processing. Complex lane line shapes require high-dimensional output of CNNs to model global structures, which further increases the demand for model capacity and training data. In contrast, the locality of a lane marker has finite geometric variations and spatial coverage. We propose a novel lane marker detection solution, FOLOLane, that focuses on modeling local patterns and achieving prediction of global structures in a bottom-up manner. Specifically, the CNN models lowcomplexity local patterns with two separate heads, the first one predicts the existence of key points, and the second refines the location of key points in the local range and correlates key points of the same lane line. The locality of the task is consistent with the limited FOV of the feature in CNN, which in turn leads to more stable training and better generalization. In addition, an efficiency-oriented decoding algorithm was proposed as well as a greedy one, which achieving 36% runtime gains at the cost of negligible performance degradation. Both of the two decoders integrated local information into the global geometry of lane markers. In the absence of a complex network architecture design, the proposed method greatly outperforms all existing methods on public datasets while achieving the best state-of-the-art results and real-time processing simultaneously.

cs.CV