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Zhaoqian Xue

Publications and source records attributed to Zhaoqian Xue.

9 recordsLinked to original sources

Skill-RAG: Failure-State-Aware Retrieval Augmentation via Hidden-State Probing and Skill Routing

Retrieval-Augmented Generation (RAG) has emerged as a foundational paradigm for grounding large language models in external knowledge. While adaptive retrieval mechanisms have improved retrieval efficiency, existing approaches treat post-retrieval failure as a signal to retry rather than to diagnose -- leaving the structural causes of query-evidence misalignment unaddressed. We observe that a significant portion of persistent retrieval failures stem not from the absence of relevant evidence but from an alignment gap between the query and the evidence space. We propose Skill-RAG, a failure-aware RAG framework that couples a lightweight hidden-state prober with a prompt-based skill router. The prober gates retrieval at two pipeline stages; upon detecting a failure state, the skill router diagnoses the underlying cause and selects among four retrieval skills -- query rewriting, question decomposition, evidence focusing, and an exit skill for truly irreducible cases -- to correct misalignment before the next generation attempt. Experiments across multiple open-domain QA and complex reasoning benchmarks show that Skill-RAG substantially improves accuracy on hard cases persisting after multi-turn retrieval, with particularly strong gains on out-of-distribution datasets. Representation-space analyses further reveal that the proposed skills occupy structured, separable regions of the failure state space, supporting the view that query-evidence misalignment is a typed rather than monolithic phenomenon.

cs.CL

Knowledge-augmented Agentic AI for Mental Health Medication Information Seeking

Patients increasingly seek medication information online, yet safety knowledge for psychiatric drugs is split between regulatory adverse-event records, which are authoritative but abstract, and patient narratives, which are experience-near but unvalidated. Integrating them without conflating evidence and anecdote is especially consequential in psychiatry, where poorly contextualised information can amplify fear, nocebo responses, and non-adherence. Here we develop a provenance-aware, knowledge-graph-based multi-agent framework unifying 466,525 Reddit posts, 60,782 WebMD reviews, and twenty years of U.S. FDA Adverse Event Reporting System records for nine antidepressants. A large-language-model entity-recognition pipeline benchmarked against physician annotations reached highest F1 scores of 0.969 for medications and 0.973 for conditions. The two community platforms were far more concordant with each other (overlap up to a Jaccard similarity of 0.905) than with regulatory reports, indicating that patient-generated data form a partly independent safety signal. For sertraline, many adverse events appeared in community sources hundreds of days before the corresponding FDA date. A Neo4j knowledge graph grounded in ATC-N, ICD-10, and MedDRA vocabularies preserves provenance, keeping every claim traceable and regulatory facts distinct from patient experience. These results establish source-aware integration as a route to more auditable psychiatric medication information, with usefulness and patient benefit to be tested prospectively.

cs.AI

Patients Speak, AI Listens: LLM-based Analysis of Online Reviews Uncovers Key Drivers for Urgent Care Satisfaction

Investigating the public experience of urgent care facilities is essential for promoting community healthcare development. Traditional survey methods often fall short due to limited scope, time, and spatial coverage. Crowdsourcing through online reviews or social media offers a valuable approach to gaining such insights. With recent advancements in large language models (LLMs), extracting nuanced perceptions from reviews has become feasible. This study collects Google Maps reviews across the DMV and Florida areas and conducts prompt engineering with the GPT model to analyze the aspect-based sentiment of urgent care. We first analyze the geospatial patterns of various aspects, including interpersonal factors, operational efficiency, technical quality, finances, and facilities. Next, we determine Census Block Group (CBG)-level characteristics underpinning differences in public perception, including population density, median income, GINI Index, rent-to-income ratio, household below poverty rate, no insurance rate, and unemployment rate. Our results show that interpersonal factors and operational efficiency emerge as the strongest determinants of patient satisfaction in urgent care, while technical quality, finances, and facilities show no significant independent effects when adjusted for in multivariate models. Among socioeconomic and demographic factors, only population density demonstrates a significant but modest association with patient ratings, while the remaining factors exhibit no significant correlations. Overall, this study highlights the potential of crowdsourcing to uncover the key factors that matter to residents and provide valuable insights for stakeholders to improve public satisfaction with urgent care.

cs.CL

Toward Equitable Access: Leveraging Crowdsourced Reviews to Investigate Public Perceptions of Health Resource Accessibility

Monitoring health resource disparities during public health crises is critical, yet traditional methods, like surveys, lack the requisite speed and spatial granularity. This study introduces a novel framework that leverages: 1) crowdsourced Google Maps reviews (2018-2021) and 2) advanced NLP (DeBERTa) to create a high-resolution, spatial-temporal index of public perception of health resource accessibility in the United States. We then employ Partial Least Squares (PLS) regression to link this perception index to a range of socioeconomic and demographic drivers. Our results quantify significant spatial-temporal shifts in perceived access, confirming that disparities peaked during the COVID-19 crisis and only partially recovered post-peak. We identify political affiliation, racial composition, and educational attainment as primary determinants of these perceptions. This study validates a scalable method for real-time health equity monitoring and provides actionable evidence for interventions to build a more resilient healthcare infrastructure.

cs.CL

Deciphering Scientific Collaboration in Biomedical LLM Research: Dynamics, Institutional Participation, and Resource Disparities

Large language models (LLMs) are increasingly transforming biomedical discovery and clinical innovation, yet their impact extends far beyond algorithmic revolution-LLMs are restructuring how scientific collaboration occurs, who participates, and how resources shape innovation. Despite this profound transformation, how this rapid technological shift is reshaping the structure and equity of scientific collaboration in biomedical LLM research remains largely unknown. By analyzing 5,674 LLM-related biomedical publications from PubMed, we examine how collaboration diversity evolves over time, identify institutions and disciplines that anchor and bridge collaboration networks, and assess how resource disparities underpin research performance. We find that collaboration diversity has grown steadily, with a decreasing share of Computer Science and Artificial Intelligence authors, suggesting that LLMs are lowering technical barriers for biomedical investigators. Network analysis reveals central institutions, including Stanford University and Harvard Medical School, and bridging disciplines such as Medicine and Computer Science that anchor collaborations in this field. Furthermore, biomedical research resources are strongly linked to research performance, with high-performing resource-constrained institutions exhibiting larger collaboration volume with the top 1% most connected institutions in the network. Together, these findings reveal a complex landscape, where democratizing trends coexist with a persistent, resource-driven hierarchy, highlighting the critical role of strategic collaboration in this evolving field.

cs.SI

Towards Trustworthy AI: Characterizing User-Reported Risks across LLMs "In the Wild"

While Large Language Models (LLMs) are rapidly integrating into daily life, research on their risks often remains lab-based and disconnected from the problems users encounter "in the wild." While recent HCI research has begun to explore these user-facing risks, it typically concentrates on a singular LLM chatbot like ChatGPT or an isolated risk like privacy. To gain a holistic understanding of multi-risk across LLM chatbots, we analyze online discussions on Reddit around seven major LLM chatbots through the U.S. NIST's AI Risk Management Framework. We find that user-reported risks are unevenly distributed and platform-specific. While "Valid and Reliable" risk is the most frequently mentioned, each product also exhibits a unique "risk fingerprint;" for instance, user discussions associate GPT more with "Safe" and "Fair" issues, Gemini with "Privacy," and Claude with "Secure and Resilient" risks. Furthermore, the nature of these risks differs by their prevalence: less frequent risks like "Explainability" and "Privacy" manifest as nuanced user trade-offs, more common ones like "Fairness" are experienced as direct personal harms. Our findings reveal gaps between risks reported by system-centered studies and by users, highlighting the need for user-centered approaches that support users in their daily use of LLM chatbots.

cs.CY

What if LLMs Have Different World Views: Simulating Alien Civilizations with LLM-based Agents

This study introduces "CosmoAgent," an innovative artificial intelligence system that utilizes Large Language Models (LLMs) to simulate complex interactions between human and extraterrestrial civilizations. This paper introduces a mathematical model for quantifying the levels of civilization development and further employs a state transition matrix approach to evaluate their trajectories. Through this methodology, our study quantitatively analyzes the growth trajectories of civilizations, providing insights into future decision-making at critical points of growth and saturation. Furthermore, this paper acknowledges the vast diversity of potential living conditions across the universe, which could foster unique cosmologies, ethical codes, and worldviews among different civilizations. Recognizing the Earth-centric bias inherent in current LLM designs, we propose the novel concept of using LLM agents with diverse ethical paradigms and simulating interactions between entities with distinct moral principles. This innovative research not only introduces a novel method for comprehending potential inter-civilizational dynamics but also holds practical value in enabling entities with divergent value systems to strategize, prevent conflicts, and engage in games under conditions of asymmetric information. The accompanying code is available at https://github.com/MingyuJ666/Simulating-Alien-Civilizations-with-LLM-based-Agents.

cs.CL

Crowdsourcing-Based Knowledge Graph Construction for Drug Side Effects Using Large Language Models with an Application on Semaglutide

Social media is a rich source of real-world data that captures valuable patient experience information for pharmacovigilance. However, mining data from unstructured and noisy social media content remains a challenging task. We present a systematic framework that leverages large language models (LLMs) to extract medication side effects from social media and organize them into a knowledge graph (KG). We apply this framework to semaglutide for weight loss using data from Reddit. Using the constructed knowledge graph, we perform comprehensive analyses to investigate reported side effects across different semaglutide brands over time. These findings are further validated through comparison with adverse events reported in the FAERS database, providing important patient-centered insights into semaglutide's side effects that complement its safety profile and current knowledge base of semaglutide for both healthcare professionals and patients. Our work demonstrates the feasibility of using LLMs to transform social media data into structured KGs for pharmacovigilance.

cs.AI

Sympathy over Polarization: A Computational Discourse Analysis of Social Media Posts about the July 2024 Trump Assassination Attempt

On July 13, 2024, at the Trump rally in Pennsylvania, someone attempted to assassinate Republican Presidential Candidate Donald Trump. This attempt sparked a large-scale discussion on social media. We collected posts from X (formerly known as Twitter) one week before and after the assassination attempt and aimed to model the short-term effects of such a ``shock'' on public opinions and discussion topics. Specifically, our study addresses three key questions: first, we investigate how public sentiment toward Donald Trump shifts over time and across regions (RQ1) and examine whether the assassination attempt itself significantly affects public attitudes, independent of the existing political alignments (RQ2). Finally, we explore the major themes in online conversations before and after the crisis, illustrating how discussion topics evolved in response to this politically charged event (RQ3). By integrating large language model-based sentiment analysis, difference-in-differences modeling, and topic modeling techniques, we find that following the attempt the public response was broadly sympathetic to Trump rather than polarizing, despite baseline ideological and regional disparities.

cs.SI