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Zhen Hua

Publications and source records attributed to Zhen Hua.

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Wavelet-Guided Dual-Frequency Encoding for Remote Sensing Change Detection

Change detection in remote sensing imagery plays a vital role in various engineering applications, such as natural disaster monitoring, urban expansion tracking, and infrastructure management. Despite the remarkable progress of deep learning in recent years, most existing methods still rely on spatial-domain modeling, where the limited diversity of feature representations hinders the detection of subtle change regions. We observe that frequency-domain feature modeling particularly in the wavelet domain an amplify fine-grained differences in frequency components, enhancing the perception of edge changes that are challenging to capture in the spatial domain. Thus, we propose a method called Wavelet-Guided Dual-Frequency Encoding (WGDF). Specifically, we first apply Discrete Wavelet Transform (DWT) to decompose the input images into high-frequency and low-frequency components, which are used to model local details and global structures, respectively. In the high-frequency branch, we design a Dual-Frequency Feature Enhancement (DFFE) module to strengthen edge detail representation and introduce a Frequency-Domain Interactive Difference (FDID) module to enhance the modeling of fine-grained changes. In the low-frequency branch, we exploit Transformers to capture global semantic relationships and employ a Progressive Contextual Difference Module (PCDM) to progressively refine change regions, enabling precise structural semantic characterization. Finally, the high- and low-frequency features are synergistically fused to unify local sensitivity with global discriminability. Extensive experiments on multiple remote sensing datasets demonstrate that WGDF significantly alleviates edge ambiguity and achieves superior detection accuracy and robustness compared to state-of-the-art methods. The code will be available at https://github.com/boshizhang123/WGDF.

cs.CV

Chemosensitivity testing of revived fresh-frozen biopsies using digital speckle holography

Enrolling patients in clinical trials to obtain fresh tumor biopsies to profile anticancer agents can be slow and expensive. However, if flash-frozen biopsies can be thawed to produce viable living tissue with relevant biodynamic profiles, then a large reservoir of tissue-banked samples could become available for phenotypic library building. Here, we report biodynamic profiles acquired from revived flash-frozen canine B-cell lymphoma biopsies using digital speckle holography. We compared the thawed-tissue drug-response spectrograms to spectrograms from fresh tissues in a study of canine B-cell lymphoma. By compensating for tissue trauma in the thawed sample, patient clustering of both the fresh and thawed samples were found to be in general agreement with clinical outcomes. This study indicates that properly frozen tumor specimens are a viable proxy for fresh specimens in the context of chemosensitivity testing, and that thawed samples from tissue banks contain sufficient viable cells to evaluate phenotypic drug response.

physics.bio-ph