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Zhilei Wang

Publications and source records attributed to Zhilei Wang.

7 recordsLinked to original sources

Multi-Energy Blended CBCT Spectral Imaging Using a Spectral Modulator with Flying Focal Spot (SMFFS)

Conventional cone-beam CT (CBCT) can be easily compromised by scatter and beam hardening artifacts, and the entanglement of scatter and spectral effects introduces additional complexity. In this work, we present the first attempt to develop a stationary spectral modulator with flying focal spot (SMFFS) technology as a promising, low-cost approach to accurately solving the X-ray scattering problem and physically enabling spectral imaging in a unified framework. To deal with the intertwined scatter-spectral challenge, we propose a novel scatter-decoupled material decomposition (SDMD) method for SMFFS based on a hypothesis of scatter similarity. Monte Carlo simulations of a pure-water cylinder phantom with different focal spot deflections show that focal spot deflections within a range of ~2 mm share quite similar scatter distributions overall. Numerical simulations using a clinical abdominal CT dataset demonstrate that SMFFS with SDMD method can achieve better material decomposition and CT number accuracy with less artifacts. Physics experiments on a tabletop CBCT system using a Gammex multi-energy CT phantom an anthropomorphic chest phantom, are carried out to demonstrate the feasibility of CBCT spectral imaging with SMFFS. For the chest phantom, the root mean square error (RMSE) in selected regions of interest (ROIs) of virtual monochromatic image (VMI) at 70 keV is 11.8 HU for SMFFS CB scan, and 14.5 and 437.6 HU for sequential 80/140 kVp (DKV) CB scan with and without scatter correction, respectively. Also, the non-uniformity among selected regions is 14.1 HU for SMFFS CB scan, and 59.4 and 184.0 HU for the DKV CB scan with and without a traditional scatter correction method, respectively. Our preliminary results show that SMFFS can enable spectral imaging with simultaneous scatter correction for CBCT and effectively improve its quantitative imaging performance.

physics.med-ph

Fast KV-Switching and Dual-Layer Flat-Panel Detector Enabled Cone-Beam CT Joint Spectral Imaging

Purpose: Fast kV-switching (FKS) and dual-layer flat-panel detector (DL-FPD) technologies have been actively studied as promising dual-energy solutions for FPD-based cone-beam computed tomography (CBCT). However, CBCT spectral imaging is known to face challenges in obtaining accurate and robust material discrimination performance due to the limited energy separation. To further improve CBCT spectral imaging capability, this work aims to promote a source-detector joint spectral imaging solution which takes advantages of both FKS and DL-FPD, and to conduct a feasibility study on the first tabletop CBCT system with the joint spectral imaging capability developed. Methods: In this work, the first FKS and DL-FPD jointly enabled multi-energy tabletop CBCT system has been developed in our laboratory. To evaluate its spectral imaging performance, a set of physics experiments are conducted, where the multi-energy and head phantoms are scanned using the 80/105/130kVp switching pairs and projection data are collected using a prototype DL-FPD. To compensate for the slightly angular mismatch between the low- and high-energy projections in FKS, a dual-domain projection completion scheme is implemented. Afterwards material decomposition is carried out by using the maximum-likelihood method, followed by reconstruction of basis material and virtual monochromatic images. Results: The physics experiments confirmed the feasibility and superiority of the joint spectral imaging, whose CNR of the multi-energy phantom were boosted by an average improvement of 21.9%, 20.4% for water and 32.8%, 62.8% for iodine when compared with that of the FKS and DL-FPD in fan-beam and cone-beam experiments, respectively. Conclusions: A feasibility study of the joint spectral imaging for CBCT by utilizing both the FKS and DL-FPD was conducted, with the first tabletop CBCT system having such a capability being developed.

physics.med-ph

A New Approach to Drifting Games, Based on Asymptotically Optimal Potentials

We develop a new approach to drifting games, a class of two-person games with many applications to boosting and online learning settings. Our approach involves (a) guessing an asymptotically optimal potential by solving an associated partial differential equation (PDE); then (b) justifying the guess, by proving upper and lower bounds on the final-time loss whose difference scales like a negative power of the number of time steps. The proofs of our potential-based upper bounds are elementary, using little more than Taylor expansion. The proofs of our potential-based lower bounds are also elementary, combining Taylor expansion with probabilistic or combinatorial arguments. Not only is our approach more elementary, but we give new potentials and derive corresponding upper and lower bounds that match each other in the asymptotic regime.

cs.LG

Fast Rates in Pool-Based Batch Active Learning

We consider a batch active learning scenario where the learner adaptively issues batches of points to a labeling oracle. Sampling labels in batches is highly desirable in practice due to the smaller number of interactive rounds with the labeling oracle (often human beings). However, batch active learning typically pays the price of a reduced adaptivity, leading to suboptimal results. In this paper we propose a solution which requires a careful trade off between the informativeness of the queried points and their diversity. We theoretically investigate batch active learning in the practically relevant scenario where the unlabeled pool of data is available beforehand ({\em pool-based} active learning). We analyze a novel stage-wise greedy algorithm and show that, as a function of the label complexity, the excess risk of this algorithm matches the known minimax rates in standard statistical learning settings. Our results also exhibit a mild dependence on the batch size. These are the first theoretical results that employ careful trade offs between informativeness and diversity to rigorously quantify the statistical performance of batch active learning in the pool-based scenario.

cs.LG

Neural Active Learning with Performance Guarantees

We investigate the problem of active learning in the streaming setting in non-parametric regimes, where the labels are stochastically generated from a class of functions on which we make no assumptions whatsoever. We rely on recently proposed Neural Tangent Kernel (NTK) approximation tools to construct a suitable neural embedding that determines the feature space the algorithm operates on and the learned model computed atop. Since the shape of the label requesting threshold is tightly related to the complexity of the function to be learned, which is a-priori unknown, we also derive a version of the algorithm which is agnostic to any prior knowledge. This algorithm relies on a regret balancing scheme to solve the resulting online model selection problem, and is computationally efficient. We prove joint guarantees on the cumulative regret and number of requested labels which depend on the complexity of the labeling function at hand. In the linear case, these guarantees recover known minimax results of the generalization error as a function of the label complexity in a standard statistical learning setting.

cs.LG

New Potential-Based Bounds for Prediction with Expert Advice

This work addresses the classic machine learning problem of online prediction with expert advice. We consider the finite-horizon version of this zero-sum, two-person game. Using verification arguments from optimal control theory, we view the task of finding better lower and upper bounds on the value of the game (regret) as the problem of finding better sub- and supersolutions of certain partial differential equations (PDEs). These sub- and supersolutions serve as the potentials for player and adversary strategies, which lead to the corresponding bounds. To get explicit bounds, we use closed-form solutions of specific PDEs. Our bounds hold for any given number of experts and horizon; in certain regimes (which we identify) they improve upon the previous state of the art. For two and three experts, our bounds provide the optimal leading order term.

cs.LG

New Potential-Based Bounds for the Geometric-Stopping Version of Prediction with Expert Advice

This work addresses the classic machine learning problem of online prediction with expert advice. A new potential-based framework for the fixed horizon version of this problem has been recently developed using verification arguments from optimal control theory. This paper extends this framework to the random (geometric) stopping version. To obtain explicit bounds, we construct potentials for the geometric version from potentials used for the fixed horizon version of the problem. This construction leads to new explicit lower and upper bounds associated with specific adversary and player strategies. While there are several known lower bounds in the fixed horizon setting, our lower bounds appear to be the first such results in the geometric stopping setting with an arbitrary number of experts. Our framework also leads in some cases to improved upper bounds. For two and three experts, our bounds are optimal to leading order.

cs.LG