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Zhitong Chen

Publications and source records attributed to Zhitong Chen.

At least 19 recordsLinked to original sources

DisasterBench: Benchmarking LLM Planning under Typed Tool Interface Constraints

Disasters cause severe societal impacts, demanding rapid coordination of heterogeneous AI tools, from satellite analysis to flood prediction and damage assessment, into coherent multi-step workflows. As LLMs increasingly serve as orchestrators of such pipelines, effective coordination requires more than selecting semantically plausible tools: LLMs must generate executable workflows with correct parameter binding and dependency propagation. We introduce DisasterBench, a benchmark for evaluating structured multi-agent planning over semantically similar but operationally distinct disaster-response tools. To enable step-level failure attribution, we further propose First-Point-of-Failure (FPoF), which localizes the earliest root cause in a predicted workflow, separating primary errors from downstream cascading effects. Our evaluation reveals three findings: planning method effectiveness depends strongly on model capacity; tool mismatch and parameter-binding errors dominate first failures, revealing semantic grounding and execution consistency as distinct bottlenecks; and verbose intermediate reasoning can create instruction clash with structured output requirements, disrupting plan generation. Together, these findings highlight a fundamental gap between semantic reasoning and execution-grounded coordination, underscoring the need for planning frameworks that jointly model semantic intent, execution constraints, and workflow consistency. Code, data, and evaluation resources are available at: https://github.com/TamuChen18/DisasterBench_Open

cs.CL

DisastRAG: A Multi-Source Disaster Information Integration and Access System Based on Retrieval-Augmented Large Language Models

Effective disaster management requires rapid access to information distributed across structured operational records, unstructured institutional documents, and dynamic external sources. However, most existing disaster information systems and retrieval-augmented generation frameworks remain organized around a single access pathway, limiting their ability to support heterogeneous, time-sensitive, and context-dependent information needs. This study presents DisastRAG, a disaster-aware information integration and access system that combines large language models with retrieval-augmented access to structured, unstructured, and contextual disaster information. The framework is built around a multi-path architecture that supports document retrieval over a curated hazard corpus, structured access over relational disaster records, and external web fallback for out-of-corpus requests, while also incorporating query understanding, strategy routing, response generation, and contextual memory within a unified system. We evaluated the document retrieval performance using four open-source large language models across multiple retrieval configurations on multiple-choice and open-ended disaster information tasks. Retrieval augmentation consistently improves performance over no-retrieval baselines, yielding multiple-choice gains of 12-23 percentage points and open-ended keypoint coverage gains of up to 10.5 percentage points. Results show that larger candidate pools are most helpful for weaker models, while stronger models are more sensitive to retrieval noise. Hybrid retrieval performs best for open-ended coverage, whereas vector retrieval and shallower reranking more often favor closed-form factual selection. Case studies further show that structured access and web fallback extend the framework beyond document-only RAG.

cs.IR

Deep-Picard Iteration for Space-time Fractional Diffusion PDEs

We propose a Deep-Picard iteration framework for high-dimensional nonlinear space-time fractional diffusion equations.The method is based on a nonlinear fractional Feynman--Kac fixed-point formulation, which replaces direct discretization of the Caputo memory term and the nonlocal fractional Laplacian by Monte Carlo simulation of the associated fractional dynamics. Each Picard update is approximated by stochastic label generation and realized through supervised neural-network regression, thereby avoiding residual minimization involving fractional differential operators. The fractional trajectories are generated by coupling a discretized beta-stable subordinator with a walk-on-spheres-type simulation of the rotationally symmetric alpha-stable Lévy process. Numerical experiments on two-dimensional and high-dimensional test problems ddemonstrate stable Picard convergence and accurate approximation, with tests reported up to dimension d=100.

math.NA

FloodSQL-Bench: A Retrieval-Augmented Benchmark for Geospatially-Grounded Text-to-SQL

Existing Text-to-SQL benchmarks primarily focus on single-table queries or limited joins in general-purpose domains, and thus fail to reflect the complexity of domain-specific, multi-table and geospatial reasoning, To address this limitation, we introduce FLOODSQL-BENCH, a geospatially grounded benchmark for the flood management domain that integrates heterogeneous datasets through key-based, spatial, and hybrid joins. The benchmark captures realistic flood-related information needs by combining social, infrastructural, and hazard data layers. We systematically evaluate recent large language models with the same retrieval-augmented generation settings and measure their performance across difficulty tiers. By providing a unified, open benchmark grounded in real-world disaster management data, FLOODSQL-BENCH establishes a practical testbed for advancing Text-to-SQL research in high-stakes application domains.

cs.IR

DisastQA: A Comprehensive Benchmark for Evaluating Question Answering in Disaster Management

Accurate question answering (QA) in disaster management requires reasoning over uncertain and conflicting information, a setting poorly captured by existing benchmarks built on clean evidence. We introduce DisastQA, a large-scale benchmark of 3,000 rigorously verified questions (2,000 multiple-choice and 1,000 open-ended) spanning eight disaster types. The benchmark is constructed via a human-LLM collaboration pipeline with stratified sampling to ensure balanced coverage. Models are evaluated under varying evidence conditions, from closed-book to noisy evidence integration, enabling separation of internal knowledge from reasoning under imperfect information. For open-ended QA, we propose a human-verified keypoint-based evaluation protocol emphasizing factual completeness over verbosity. Experiments with 20 models reveal substantial divergences from general-purpose leaderboards such as MMLU-Pro. While recent open-weight models approach proprietary systems in clean settings, performance degrades sharply under realistic noise, exposing critical reliability gaps for disaster response. All code, data, and evaluation resources are available at https://github.com/TamuChen18/DisastQA_open.

cs.CL

Mechanisms and safety of air plasma inactivated SARS-CoV-2

Cold atmospheric plasma (CAP) displays antimicrobial, antitumor, and antiviral properties, while the underlying mechanism is seldom clearly elucidated. In this work, we employed CAP with air-feeding gas to directly inactivate SARS-CoV-2. The results indicate that the typical SARS-CoV-2 morphological spikes disappeared after plasma treatment and the proteosomes of SRAS-CoV-2 were modified. In addition, we also evaluated the safety of the air plasma device in simulating daily life environments through rat experiments. We evaluated rats' daily physiological behavior, body weight, food consumption, organ histopathology, blood biochemical indicators, and so on. These results demonstrate air plasma device is a safe and effective mean prevents virus transmissions and infections.

physics.plasm-ph

Cold plasma with zirconia nanoparticles for lung cancer via TGF-\b{eta} signaling pathway

Despite advancements in lung cancer therapy, the prognosis for advanced or metastatic patients remains poor, yet many patients eventually develop resistance to standard treatments leading to disease progression and poor survival. Here, we described a combination of CAP and nanoparticles (ZrO2 NPs (zirconium oxide nanoparticle) and 3Y-TZP NPs (3% mol Yttria Tetragonal Zirconia Polycrystal Nanoparticle)) for lung cancer therapy. We found that ZrO2 NPs caused obvious damage to the inside of the lung cancer cells. CAP and ZrO2 NPs mainly affected the mitochondria function, leading to a decrease in mitochondrial membrane potential and ATP levels, and causing endoplasmic reticulum stress and cell nucleus internal DNA damage, etc. CAP combined with ZrO2 NPs (CAP@ZrO2) induced lung cancer cell apoptosis by activating the TGF-\b{eta} pathway. CAP@ZrO2 offers a new therapy for the clinical treatment of lung cancer.

physics.bio-ph

Cold plasma treatment for biomedical applications: using aluminum foam to reduce risk while increasing efficacy

Plasma medicine is an emerging and innovative interdisciplinary research field combining biology, chemistry, physics, engineering, and medicine. However, the safe clinical application of cold atmospheric plasma (CAP) technology is still a challenge. Here, we examine the use of aluminum (Al) foam with three pores-per-inch (PPI) ratings in clinical plasma applications. Al foams can filter sparks to avoid damage from high voltage discharge during surgery and efficiently deliver reactive species generated in CAP to the target. The sparks appear and plasma intensity increases at the foam/discharge interface, which just slightly increases the interface temperature without changing the interface microstructure during a 30-minute treatment. After CAP penetrated the Al foams, N2, N2+, *OH, O, and He emission peaks were characterized, and the highest values appeared using Al foams with 10 PPI. CAP with and without Al foam intermediating was used to treat deionized water, and the results indicate CAP in combination with 10 PPI Al foam led to much higher ROS concentration than CAP alone. For melanoma cell experiments, CAP with and without Al foam had a similar effect on cell viability after 30-second treatment, while CAP with the 10-PPI Al foam had much higher killing efficiency than CAP alone after 60-second treatment. In summary, 10-PPI Al foam can not only prevent damage to tissues resulting from high discharge voltage during clinical surgery but also increase the delivery efficiency of reactive species generated in plasma for biomedical applications.

physics.med-ph

Air cold atmospheric plasma with patterns for anaplastic squamous cell carcinoma treatment

In recent years, cold atmospheric plasma (CAP) using inert gas has been successfully applied for biomedicine, such as sterilization, wound healing, skin diseases, and tumor treatment. Here, we reported air cold atmospheric plasma with three different patterns (I. Non: basic square grid structure; II. Square: basic square grid structure + square node; III. Circle: basic square grid structure + circle node) for anaplastic squamous cell carcinoma treatment (VX2 cell line). Various plasma diagnostic techniques were applied to evaluate the physics of air CAP with patterns such as discharge voltage, plasma initial generating process, plasma temperature, and optical emission spectroscopy (OES). The direct effects of air CAP with patterns on anaplastic squamous cell carcinoma treatment (VX2 cell line) were investigated in vitro. We also studied the ROS (reactive oxygen species) and RNS (reactive nitrogen species) generation in cultured media released from VX2 cells after the treatment of air CAP with patterns. The results showed that the air CAP with circle-pattern generated more active substances during at 60s treatment time, which resulted in a higher death rate of VX2 cells. These initial observations establish the air CAP with patterns as potential clinical applications for cancer therapy.

physics.med-ph

Cold atmospheric plasma activated deionized water using helium, argon, and nitrogen as feeding gas for cancer therapy

Plasma activated medium, containing reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been used for cancer treatment as an indirect treatment method. Here we report cold atmospheric plasma (CAP) activated deionized (DI) water using helium (He), argon (Ar), and nitrogen (N2) as feeding gas for the cancer therapy. Basic characteristics of CAP activated DI water with different feeding gases were diagnosed and the effects of three solutions on the breast cancer cells and gastric cancer cells were also recorded. Our findings show that DI water treated by CAP with He feeding gas has a much stronger effect on apoptosis in precultured breast cancer cells and gastric cancer cells. These results are attributed to the higher concentration of ROS generated in CAP-activated DI water using He as feeding gas.

physics.bio-ph

Effect of He Self-organized pattern plasma-activated media with different conductivity on cancer cells

The self-organized pattern (SOP) phenomenon is prevalent in plasma, while knowledge about SOP discharge affecting reactive species generated plasma-activated media (PAM) for cancer therapy is poorly documented. The aim of this study focused on the effect of SOP discharge modes on reactive oxygen and nitrogen species (ROS, RNS) in He SOP plasma-activated media with different conductivity (saline solution and deionized (DI) water), and employed them to breast cancer MDA-MB-231 and pancreatic BxPC-3 cancer cells. Optical emission spectrum and Fluorimetric analysis were used to identify and quantify ROS and RNS generated in He SOP plasma-activated saline solution and DI water. Furthermore, He SOP plasma discharge modes are capable of efficiently controlling the ROS and RNS concentration in the plasma-activated saline solution and DI water, which contribute to the cytotoxic effect. On the other hand, stainless steel and copper were used as a lower electrode to compare their effect on cell viability. Taken together, our findings provide insight into potential mechanisms involved in cell death after treatment with He SOP plasma-activated media.

physics.bio-ph

Micro-sized cold atmospheric plasma source for brain and breast cancer treatment

Micro-sized cold atmospheric plasma (uCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, uCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma U87) and breast (MDA-MB-231) cancer cells. Various diagnostic techniques were employed to evaluate the parameters of uCAP devices with different lengths such as potential distribution, electron density, and optical emission spectroscopy. The generation of short- and long-lived species (such as hydroxyl radical (.OH), superoxide (O2-), hydrogen peroxide (H2O2), nitrite (NO2-), et al) were studied. These data revealed that uCAP treatment with a 20 mm length tube has a stronger effect than that of the 60 mm tube due to the synergetic effects of reactive species and free radicals. Reactive species generated by uCAP enhanced tumor cell death in a dose-dependent fashion and was not specific with regards to tumor cell type.

q-bio.TO

Electrochemical and mechanical behaviors of dissimilar friction stir welding between 5086 and 6061 aluminum alloy

The electrochemical behavior and mechanical properties of friction stir welded AA5086 and AA6061 Al alloys were investigated. Micro-hardness measurements and tensile tests showed that the heat-affected zone (HAZ) in AA6061 had minimum hardness value (i.e., 88 HV) and served as failure site in the dissimilar weld. Corrosion testing revealed that the minimum value of Icorr appeared in the HAZ 5086 (0.54 uA/cm2) and HAZ 5086 was most resistant to corrosion. The AA 5086 side of the weld showed better corrosion resistance than the AA 6061 side.

cond-mat.mtrl-sci

In vitro Demonstration of Cancer Inhibiting Properties from Stratified Self-Organized Micro-Discharge Plasma-Liquid Interface

Experiments have revealed a nontrivial cancer-inhibiting capability of liquid media treated by the plasma jet capable of forming thinly stratified self-organized patterns at a plasma-liquid interface. A pronounced cancer depressing activity towards at least two kinds of human cancer cells, namely breast cancer MDA-MB-231 and human glioblastoma U87 cancer lines, was demonstrated. After a short treatment at the thinly stratified self-organized plasma-liquid interface pattern, the cancer inhibiting media demonstrate well pronounced depression and apoptosis activities towards tumor cells, not achievable without interfacial stratification of plasma jet to thin (of several um) current filaments, which therefore play a pivotal (yet still not completely clear) role in building up the cancer inhibition properties. Moreover, thinly stratified, self-organized interfacial discharge is capable to efficiently control the ROS and RNS concentrations in the cancer-inhibiting media, and in particular, abnormal ROS/RNS ratios not achievable in discharges which do not form stratified thin-filament patterns could be obtained. These results were explained in terms of interaction of thin plasma filaments of the self-organized pattern with gas and liquid, where the unusual interaction conditions (i.e., high surface-to-volume ratios etc.) cause accumulation of ROS, RNS and other species in unusual ratios and concentrations, thus forming potentially efficient anti-cancer cocktail. Our funding could be extremely important for handling the cancer proliferation problem, and hence, it should be brought to light to attract due attention of the researchers and explore the possible potential of this approach in tackling the challenging problem of high cancer-induced mortality and rising morbidity trends.

physics.med-ph

Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

Cold atmospheric plasma (CAP) was shown to affect cells not only directly, but also indirectly by means of plasma pre-treated solution. This study investigated a new application of CAP generated in deionized (DI) water for the cancer therapy. In our experiments, the CAP solution was generated in DI water using helium as carrier gas. We report on the effects of this plasma solution in breast (MDA-MD-231) and gastric (NCI-N87) cancer cells. The results revealed that apoptosis efficiency was dependent on the plasma exposure time and on the levels of reactive oxygen and nitrogen species (ROS and RNS). The plasma solution that resulted from 30-minute treatment of DI water had the most significant effect in the rate of apoptosis.

physics.med-ph

Cold Atmospheric Plasma discharged in Water and its Potential Use in Cancer Therapy

Cold atmospheric plasma (CAP) has been emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this study we report indirect plasma treatment using CAP discharged in DI water using three gases as carriers (argon, helium and nitrogen). Plasma stimulated water was applied to human breast cancer cell line (MDA-MB-231). MTT assay tests showed that using argon plasma had the strongest effect on inducing apoptosis in cultured human breast cancer cells. This result is attributed to the elevated production of the reactive oxygen species and reactive nitrogen species in water in the case of argon plasma.

physics.med-ph

Treatment of gastric cancer cells with non-thermal atmospheric plasma generated in water

Non-thermal atmospheric plasma (NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. Even though studies report on the successful use of NTAP to directly irradiate cancer cells, this technology can cause cell death only in the upper 3-5 cell layers. We report on a NTAP argon solution generated in DI water for treating human gastric cancer cells (NCl-N87). Our findings showed that the plasma generated in DI water during a 30-minute treatment had the strongest affect in inducing apoptosis in cultured human gastric cancer cells. This result can be attributed to presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced in water during treatment. Furthermore, the data showed that elevated levels of RNS may play an even more significant role than ROS in the rate of apoptosis in gastric cancer cells.

q-bio.TO

A study on the mechanical property and corrosion sensitivity of an AA5086 friction stir welded joint

The mechanical property and corrosion sensitivity of a friction stir welded (FSW) AA5086 joint have been investigated. Vickers microhardness and tensile tests showed that the TMAZ/HAZ zone had the lowest microhardness value and the tensile specimen (transverse to the weld) failed in this region. Polarization experiments conducted using samples cut from each zone indicated that the HAZ had the lowest corrosion rate in 3.15 wt.% NaCl. SEM observation of the samples, Raman spectroscopic and XRD characterization of the corrosion products, and weight loss analysis after immersion tests all showed that the corrosion severity of AA5086 decreased from 3.15% NaCl to ASTM seawater and finally to 0.5 M Na2SO4. In addition, less corrosion products were observed from HAZ as compared to the other three regions, which was in agreement with the Raman and XRD analyses.

cond-mat.mtrl-sci