arXiv subjects

Zhiyong Lu

Publications and source records attributed to Zhiyong Lu.

2 recordsLinked to original sources

arXiv2026

Towards AI-Assisted Clinical Trial Matching: Practical Considerations, Multicenter Evaluation, and Real-World Deployment

Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world oncology workflows. Here we present TrialGPT 2.0, an AI-assisted clinical trial recommendation system designed for real-world deployment. Rather than asking only whether a patient may qualify, the system also assesses which trials warrant further consideration given the patient's current clinical needs and local workflow priorities, and provides structured, inspectable explanations for expert review. Importantly, we evaluated TrialGPT 2.0 retrospectively and prospectively across multiple oncology-focused settings, spanning government, academic cancer-center, patient-advocacy, and NIH referral workflows. In retrospective multicenter cohorts comprising 288 cases, TrialGPT 2.0 retrieved at least one clinician-recommended trial in its top 10 recommendations for approximately 91% of cases while reducing clinician screening time by 55.0%. In a six-month prospective evaluation embedded in an active precision oncology tumor board, TrialGPT 2.0 contributed additional trial opportunities missed by the routine workflow, expanding patient access to clinical trial participation by 90.9%. To support scientific reproducibility, we also introduce NIH-TrialBench, a clinician-authored dataset comprising 126 diverse synthetic patient vignettes and matching scenarios from 11 NIH Institutes and Centers. Together, these results support the value of AI to assist clinical trial matching by improving clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.

cs.CL↗

arXiv2026

Engaging the scientific community in high-quality biocuration: a report on the International Society for Biocuration workshop, 'Maximizing community curation for the benefit of all'

Biological knowledgebases traditionally rely on expert, professional curation of the research literature to maintain up-to-date collections of data organized in machine-readable form. However, despite the increasing amount of curatable biomedical knowledge, support for knowledgebases is declining, leaving these resources no alternative but to explore additional ways of updating and maintaining content. One way in which knowledgebases have addressed this problem is by engaging researchers to help curate their published papers, a process generally known as 'community curation'. As helpful as community curation can be, though, it is not universally adopted and, for groups that do have it, there is a wide range of approaches. To learn about existing community curation pipelines and explore possibilities for working towards a common approach, we organized a workshop, Maximizing Community Curation for the Benefit of All, at the 18th International Biocuration Conference, hosted by the Stowers Institute for Medical Research. Our aim was to examine the different strategies that groups use, share successes, failures, and ongoing challenges, and produce suggested deliverables for broader adoption of common best practices and tools for effective community curation. Representatives from 18 different resources, ranging from model organism and specialty knowledgebases to journals and literature resources, presented their work. The result was a comprehensive assessment of the state-of-the-art for community curation and an in-depth discussion on how community curation can become standard practice for maintaining timely, highquality biological resources that will continue to provide scientists with the essential information they need for their research.

cs.DB↗