arXiv subjects

Zihan Li

Publications and source records attributed to Zihan Li.

At least 37 records · Page 2Linked to original sources

arXiv2026

INFANiTE: Implicit Neural representation for high-resolution Fetal brain spatio-temporal Atlas learNing from clinical Thick-slicE MRI

Spatio-temporal fetal brain atlases are important for characterizing normative neurodevelopment and identifying congenital anomalies. However, existing atlas construction pipelines necessitate days for slice-to-volume reconstruction (SVR) to generate high-resolution 3D brain volumes and several additional days for iterative volume registration, thereby rendering atlas construction from large-scale cohorts prohibitively impractical. We address these limitations with INFANiTE, an Implicit Neural Representation (INR) framework for high-resolution Fetal brain spatio-temporal Atlas learNing from clinical Thick-slicE MRI scans, bypassing both the costly SVR and the iterative non-rigid registration steps entirely, thereby substantially accelerating atlas construction. Extensive experiments demonstrate that INFANiTE outperforms existing baselines in subject consistency, reference fidelity, intrinsic quality and biological plausibility, even under challenging sparse-data settings. Additionally, INFANiTE reduces the end-to-end processing time (i.e., from raw scans to the final atlas) from days to hours compared to the traditional 3D volume-based pipeline (e.g., SyGN), facilitating large-scale population-level fetal brain analysis. Code: https://github.com/hu2274898/INFANiTE

cs.CV↗

arXiv2026

Astra: a generalizable report generation foundation model for 3D computed tomography

Interpreting computed tomography (CT) requires review of hundreds of volumetric slices and remains time-intensive and expertise-dependent. Automated CT report generation offers a promising route to improving clinical efficiency, yet the field still lacks a generalizable CT report generation foundation model that supports multi-region reporting and remains robust across external real-world cohorts. Intrinsic inconsistencies in reporting style and diagnostic terminology across cohorts make naive joint training difficult. Here we present Astra, a generalizable CT report generation foundation model developed on 90,678 thoracoabdominal CT-report pairs collected from five sites worldwide (CTRgDB), comprising 353,671 abnormalities spanning eight organ systems. By harmonizing report style and further refining diagnostic consistency via reinforcement learning, Astra achieves style-consistent and diagnostically accurate report generation across diverse anatomical regions and institutions. Evaluated on CTRgDB and six external cohorts, Astra achieves state-of-the-art performance with a 38.4% average improvement in fine-grained diagnostic metrics (P<0.001). Deployed at external clinical sites without any site-specific fine-tuning, Astra accelerated chest report drafting by 29.6% and improved abdominal report completeness by 11.3% among junior and mid-level radiologists (P<0.001). Furthermore, Astra demonstrates broad utility as a foundation for CT AI development, improving downstream diagnostic performance and scaling vision-language pretrain through high-quality report synthesis. Overall, Astra serves as a broadly accessible clinical assistant and a pivotal infrastructure for the next generation of AI-powered healthcare. The code for Astra is publicly available at https://github.com/zh-Wang-Med/Astra.

cs.CV↗

arXiv2026

Annotation-free deep learning for detection and segmentation of fetal germinal matrix-intraventricular hemorrhage in brain MRI

Prenatal germinal matrix-intraventricular hemorrhage (GMH-IVH) is a leading cause of infant mortality and neurodevelopmental impairment, yet its manual diagnosis and lesion segmentation on fetal brain MRI are labor-intensive and error-prone. Although supervised deep learning offers potential for automation, it typically requires large amounts of annotated GMH-IVH data, which are challenging to obtain for such a rare condition (0.5-0.9 per 1000 pregnancies). To address these problems, an annotation-free deep learning framework, FreeHemoSeg, was developed for automated detection and segmentation of GMH-IVH without any real patient annotations. Instead of learning from expert labels, FreeHemoSeg was trained on pseudo GMH-IVH images synthesized from normal fetal data guided by medical priors. The framework was evaluated in a retrospective multicentre study of 1,674 stacks of 2D T2-weighted MRI from 558 pregnant women, using data from one hospital for internal training and validation and two hospitals for external validation. FreeHemoSeg achieved the highest diagnostic and segmentation performance in both internal validation (AUROC: 0.959; AUPR: 0.928; sensitivity: 0.914; specificity: 0.966; DSC: 0.559) and external validation (AUROC: 0.930; AUPR: 0.884; sensitivity: 0.824; specificity: 0.943; DSC: 0.512), outperforming a supervised model trained on limited empirical data and unsupervised anomaly detection methods. Moreover, FreeHemoSeg assistance improved radiologists' sensitivity (from 0.882 to 0.941-1.000) and diagnostic confidence, while reducing interpretation time by 16.0-52.7%. We anticipate its immediate utility in supporting earlier diagnosis, prognostic counselling, and perinatal planning for fetal GMH-IVH. Code: https://github.com/Arktis2022/FreeHemoSeg.

eess.IV↗

arXiv2026

MapAgent: An Industrial-Grade Agentic Framework for City-scale Lane-level Map Generation

Lane-level maps are critical infrastructure for autonomous driving and lane-level navigation, yet constructing and maintaining standardized lane networks for hundreds of cities remains highly labor-intensive. Recent end-to-end vectorized mapping methods can predict lane geometry and topology directly from sensor data, but they typically treat mapping specifications and traffic regulations as implicit, dataset-dependent supervision. Moreover, in complex scenes (e.g., worn or missing markings and occlusions), correct lane configurations are often under-determined by visual evidence alone, making specification violations a major source of human post-editing. We propose MapAgent, an industrial-grade agentic architecture that augments a vectorization backbone for specification-compliant lane-map production. Rather than merely adding an agent loop to map prediction, MapAgent couples backbone perception with explicit specification verification, constraint-aware reasoning, and deterministic map editing under a bounded, verification-driven Judge-Planner-Worker loop. A vision-language Judge diagnoses errors by jointly inspecting visual evidence and draft vectors, while a tool-calling Planner generates minimal corrective edits with post-edit re-validation. To remain scalable for city-scale production, MapAgent is selectively triggered only on tiles with low backbone confidence, adding modest overhead while preserving throughput. Experiments on real-world datasets show consistent gains over strong production baselines, especially in complex and long-tail scenarios. Additionally, MapAgent has been integrated into Baidu Maps, supporting lane-level map generation for over 360 cities nationwide and elevating the overall production automation to over 95%, demonstrating MapAgent's practicality and effectiveness for large-scale lane-level map generation.

cs.AI↗

arXiv2026

WikiKV: Schema-Evolving Path-Indexed Storage for Hierarchical Knowledge Navigation

LLM-curated hierarchical knowledge bases, namely a tree-structured wiki whose nodes summarize an underlying corpus, have become a dominant substrate for retrieval-augmented applications, yet their storage layer is still treated as an implementation detail. This workload is hierarchical, query-intensive, and continuously evolving, and no existing storage model natively captures all three properties at once. We present WikiKV, a path-indexed key-value storage model purpose-built for this workload, comprising three components: (i) a data-driven schema that bootstraps the hierarchy via Intent-Anchored Schema Induction and refines it through Continuous Evolution Operators; (ii) a consistency protocol for the path-indexed storage model that precludes partial-read observations under concurrent offline rewrites without read-path locking; and (iii) a budgeted navigation operator whose search-accelerated routing reduces the expected number of LLM-assisted descent steps from d to O(1) while preserving anytime semantics with progressively refined answers. We evaluate WikiKV through real-world deployment for the WeChat Official Account AI Assistant and benchmark it against diverse baselines on the AuthTrace dataset, where it achieves balanced low per-operator latency across four query operators against relational, graph, and FS backends, and reaches 63.2% end-to-end answer correctness, exceeding multiple RAG baselines, with the gap widening on low- and high-fan-in multi-document questions. Ablation study further confirms the effectiveness of WikiKV's components.

cs.DB↗

arXiv2026

Larch: Learned Query Optimization for Semantic Predicates

With the advent of Large Language Models (LLMs), many database systems introduced semantic operators that enabled analytical queries over unstructured data (e.g. text, images, videos). Semantic operators typically incur high inference costs and latencies making semantic (AI) SQL queries challenging to apply on large scale datasets. At the same time, their semantic nature leads database engines to treat them as black boxes, making AISQL queries difficult to optimize. In this paper, we introduce Larch, a framework for optimizing the execution of semantic filters in AI SQL queries. Larch was inspired by two key observations: i) the high latency of semantic operators leaves significant room for computationally-heavy runtime optimization techniques, ii) unstructured data are typically accompanied by semantic information in the form of embeddings allowing for efficient semantic comparisons between AI_FILTER prompts and data values. Based on these two key observations, we present two Larch variants: Larch-A2C and Larch-Sel. Larch-A2C encodes arbitrary semantic filters expression tree using an embedding-augmented Gated Graph Neural Network and formulates the filter evaluation order as a Markov decision process. In contrast, Larch-Sel leverages a supervised learning model to predict filter selectivities, subsequently applying dynamic programming to find a near-optimal evaluation order for each input row. Evaluated across diverse real-world datasets and comprehensive synthetic workloads, both Larch variants always outperform existing semantic filter optimization techniques in terms of token usage. Our results demonstrate that Larch is robust across diverse workloads, reducing total token cost overhead by 3x-19x compared to Palimpzest and Quest.

cs.DB↗

arXiv2026

A physics-informed foundation model for quantitative diffusion MRI

Understanding the human brain requires access to its microscopic tissue architecture. Diffusion magnetic resonance imaging (MRI) provides the only noninvasive window into whole-brain microstructure in vivo, yet reliable quantitative mapping remains confined to specialized research settings requiring dense sampling and optimized acquisition protocols. To address this gap, we present a physics-informed generative microstructure network (PIGMENT) that learns a universal generative prior of human brain microstructure and adapts it zero-shot to each participant's measured data to recover subject-specific maps. Trained on 11375 scans spanning multiple sites, vendors, and field strengths, PIGMENT enabled reliable quantitative mapping for tensor, kurtosis, and NODDI models across external datasets from five independent centers. It remains effective where conventional fitting becomes unreliable, recovering meaningful maps from extremely sparse acquisitions while supporting downstream tractography and structural connectivity mapping. PIGMENT estimates demonstrated strong biological validity, preserving submillimeter cortical microarchitectural patterns and early-childhood white matter developmental trajectories from 10-fold accelerated scans. Furthermore, PIGMENT enables reliable quantitative tensor mapping on cost-efficient low-field systems and the extraction of tumor-related biomarkers using ultra-fast clinical protocols. Together, these results establish PIGMENT as a physics-informed foundation model that extends quantitative diffusion MRI into regimes traditionally too sparse, heterogeneous, or clinically constrained for reliable analysis.

eess.IV↗

arXiv2026

Envy-Free Allocation of Indivisible Goods via Noisy Queries

We introduce a problem of fairly allocating indivisible goods (items) in which the agents' valuations cannot be observed directly, but instead can only be accessed via noisy queries. In the two-agent setting with Gaussian noise and bounded valuations, we derive upper and lower bounds on the required number of queries for finding an envy-free allocation in terms of the number of items, $m$, and the negative-envy of the optimal allocation, $Δ$. In particular, when $Δ$ is not too small (namely, $Δ\gg m^{1/4}$), we establish that the optimal number of queries scales as $\frac{\sqrt m }{(Δ/ m)^2} = \frac{m^{2.5}}{Δ^2}$ up to logarithmic factors. Our upper bound is based on non-adaptive queries and a simple thresholding-based allocation algorithm that runs in polynomial time, while our lower bound holds even under adaptive queries and arbitrary computation time.

cs.GT↗

arXiv2026

MemCog: From Memory-as-Tool to Memory-as-Cognition in Conversational Agents

Existing agent memory systems universally follow what we term a Memory-as-Tool paradigm where a single query triggers one-shot retrieval of flat passage lists, suffering from passive invocation, reasoning-retrieval decoupling, and structural mismatch between retrieved fragments and the agent's navigational needs. We propose MemCog, a Memory-as-Cognition system that makes memory access an integral part of the reasoning process. MemCog organizes user knowledge as Navigable Memory Store with associative link graphs, exposes Cross-Dimensional Navigation Interface for multi-step reasoning-driven traversal, and employs Proactive Reasoning Protocol that drives agents to spontaneously initiate memory exploration from conversational context. We additionally construct ProactiveMemBench, the first benchmark for evaluating proactive memory triggering. Experiments show that MemCog achieves state-of-the-art on passive QA benchmarks (92.98 on LoCoMo, 95.8 on LongMemEval) while substantially outperforming baselines on ProactiveMemBench, demonstrating the advantage of Memory-as-Cognition.

cs.AI↗

arXiv2026

CoilDrop-MRI: Self-supervised physics-guided MRI reconstruction with coil dropout

Self-supervised deep learning-based methods have shown great promise for accelerated magnetic resonance imaging (MRI) reconstruction, achieving high image quality without requiring fully sampled data for training. These methods typically partition the acquired data into two disjoint subsets to construct input-target pairs for optimizing the reconstruction network. However, existing approaches perform this partition exclusively within the spatial frequency (k-space) domain, leaving the coil dimension unexplored. To enforce full exploitation of signal correlation across receiver coils, we propose CoilDrop-MRI, which applies coil-wise dropout to the input and uses the dropped data as training targets in a self-supervised framework. This method is integrated into unrolled architectures in both image-domain (SENSE) and k-space (SPIRiT) formulations. We further demonstrate its versatility by extending CoilDrop-MRI to multi-shot, phase-corrected diffusion MRI (dMRI) reconstruction. CoilDrop-MRI is extensively validated on multi-site, multi-field-strength (0.3T, 0.55T, and 3T), and multi-modality (T1-weighted, T2-weighted, T2-FLAIR, and dMRI) datasets and consistently outperforms state-of-the-art self-supervised methods, achieving quality comparable to supervised reconstruction methods without requiring fully sampled reference training data. Moreover, CoilDrop-MRI exhibits strong data efficiency and robust generalization across imaging conditions, establishing it as a practical and versatile framework for self-supervised parallel MRI reconstruction.

cs.CV↗

arXiv2026

Towards Reliable Fetal Ultrasound Interpretation with Multi-Agent Collaboration

Automated fetal ultrasound interpretation requires a workflow from visual perception, including plane recognition and anatomical segmentation, to clinical understanding, including biometric measurement and diagnostic reporting. However, the prevailing "one-task, one-model" paradigm limits systematic integration of evidence across this multi-step process. Although multimodal large language models (MLLMs) show promising visual understanding, their limited domain-specific grounding and hallucination risks restrict reliability in fetal ultrasound analysis. To address these limitations, we propose FetUSAgents, a tool-augmented multi-agent system for comprehensive fetal ultrasound interpretation, supporting visual question answering (VQA), report generation, image captioning, and video summarization. FetUSAgents coordinates task-specific visual tools through collaborative LLM agents and decomposes clinical queries into subtasks that progress from anatomical recognition to quantitative measurement. We further introduce Dual-Path Evidence Arbitration (DPEA), which integrates LLM-based deliberative reasoning with structured computational evidence from specialized visual tools. A retrieval-enhanced evidence bank consolidates intermediate findings to support traceable and clinically grounded conclusions. In addition, we construct FetUS-VQA, a dedicated VQA benchmark for fetal ultrasound, comprising 1,892 images and 3,205 question-answer pairs across 10 clinical tasks. Extensive out-of-distribution experiments show that FetUSAgents outperforms general and medical MLLMs, exceeding the strongest baseline by more than 25 percent in VQA accuracy. These results suggest a scalable route toward evidence-driven clinical assistants for prenatal imaging. Code is available.

cs.CV↗

arXiv2026

All-band photonic integrated optical parametric amplification

Optical amplifiers are ubiquitous in science and technology and are the workhorse of modern communications. Currently, virtually all amplifiers rely on atomic resonances, such as rare-earth-doped fibers, or are based on III-V semiconductors. Fueled by emerging applications, there is increased demand for amplifiers that are high-gain, broadband, low-noise, and deliver high output power outside traditional wavelength ranges. Over the past few decades, it has been shown that optical parametric amplifiers (OPAs) can address this challenge. Pioneering works on highly nonlinear optical fibers or bulk crystals have demonstrated their potential, but high pump powers and long fiber length limited their practical use. Recently, a renaissance of OPAs has occurred with the demonstration of photonic integrated circuits, which exhibit higher effective nonlinearity and enable wider bandwidths. Yet they require ultra-low loss, highly precise dispersion engineering, and large chip footprints, limiting OPA performance to date. Here, we overcome these limitations and, using periodically poled thin-film lithium tantalate (PPLT) photonic integrated circuits, we demonstrate continuous-wave optical parametric gain up to 23.5 dB, with a flat-top profile spanning across an 850 nm-wide optical wavelength window, corresponding to 100 THz and covering all communication bands. Moreover, on-chip output signal power as large as 313 mW in the optical O-band is achieved. We further realize all-optical inter-band modulation transfer between the C- and O-bands. Our approach uses cascaded second-order nonlinear processes that provide high effective third-order nonlinearities while preserving the wide material bandgap. These results establish PPLT integrated photonic circuits as a scalable platform for broadband optical amplification and frequency conversion across wavelengths where rare-earth doped amplifiers are absent.

physics.optics↗

arXiv2026

Any2Any 3D Diffusion Models with Knowledge Transfer: A Radiotherapy Planning Study

Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models trained on billion-scale datasets from vision domains have achieved impressive performance. Herein, we propose DiffKT3D, a unified Any2Any 3D diffusion framework that leverages prior knowledge from pretrained video diffusion models for efficient and clinically meaningful dose prediction. To enable flexible conditioning across multiple clinical modalities (CT, anatomical structures, body, beam settings, etc.), we introduce an Any2Any conditional paradigm utilizing modality-specific embeddings without cross-attention overhead. Further, we design a novel reinforcement learning (RL) post-training mechanism guided by a clinically-informed Scorecard explicitly tailored to institutional treatment preferences. Compared with winner of GDP-HMM challenge, DiffKT3D sets a new state-of-the-art in dose prediction by reducing voxel-level MAE from 2.07 to 1.93. In addition, DiffKT3D achieves superior image quality and preference match. These results demonstrate that transferring diffusion priors via modality-aware conditioning and clinically aligned RL post-training can provide a robust and generalizable solution for RT planning across various clinical scenarios.

cs.CV↗

arXiv2026

EXACT: an explainable anomaly-aware vision foundation model for analysis of 3D chest CT

Chest computed tomography (CT) is central to the detection and management of thoracic disease, yet the growing scale and complexity of volumetric imaging increasingly exceed what can be addressed by scan-level prediction alone. Clinically useful AI for CT must not only recognize disease across the whole volume, but also localize abnormalities and provide interpretable visual evidence. Existing vision-language foundation models typically compress scans and reports into global image-text representations, limiting their ability to preserve spatial evidence and support clinically meaningful interpretation. Here we developed EXACT, an explainable anomaly-aware foundation model for three-dimensional chest CT that learns spatially resolved representations from paired clinical scans and radiology reports. EXACT was pre-trained on 25,692 CT-reports pairs using anatomy-aware weak supervision, jointly learning organ segmentation and multi-instance anomaly localization without manual voxel-level annotations. The resulting organ-specific anomaly-aware maps assign each voxel a disease-specific anomaly score confined to its corresponding anatomy, jointly encoding lesion extent and organ-level context. In retrospective multinational and multi-center evaluations, EXACT showed broad and consistent improvements across clinically relevant CT tasks, spanning multi-disease diagnosis, zero-shot anomaly localization, downstream adaptation, and visually grounded report generation, outperforming existing three-dimensional medical foundation models. By transforming routine clinical CT scans and free-text reports into explainable voxel-level representations, EXACT establishes a scalable paradigm for trustworthy volumetric medical AI.

cs.CV↗

arXiv2026

DPEPO: Diverse Parallel Exploration Policy Optimization for LLM-based Agents

Large language model (LLM) agents that follow the sequential "reason-then-act" paradigm have achieved superior performance in many complex tasks.However, these methods suffer from limited exploration and incomplete environmental understanding, as they interact with only a single environment per step. In this paper, we first introduce a novel paradigm that enables an agent to interact with multiple environments simultaneously and share cross-trajectory experiences. Building upon this paradigm, we further propose DPEPO, a reinforcement learning (RL) algorithm that encourages the agent to perform diverse parallel exploration. There are two stages in DPEPO: initial supervised fine-tuning (SFT) imparts basic parallel reasoning and action generation, followed by reinforcement learning stage with a hierarchical reward scheme. We design a parallel trajectory-level success reward and two step-level rewards: Diverse Action Reward and Diverse State Transition Reward, which actively penalize behavioral redundancy and promote broad exploration. Extensive experiments on ALFWorld and ScienceWorld show that DPEPO achieves state-of-the-art (SOTA) success rates, while maintaining comparable efficiency to strong sequential baselines. (Code is available at https://github.com/LePanda026/Code-for-DPEPO)

cs.CL↗

arXiv2026

Adaptive Autoguidance for Item-Side Fairness in Diffusion Recommender Systems

Diffusion recommender systems achieve strong recommendation accuracy but often suffer from popularity bias, resulting in unequal item exposure. To address this shortcoming, we introduce A2G-DiffRec, a diffusion recommender that incorporates adaptive autoguidance, where the main model is guided by a less-trained version of itself. Instead of using a fixed guidance weight, A2G-DiffRec learns to adaptively weigh the outputs of the main and weak models during training, supervised by a fairness-aware regularization that promotes balanced exposure across items with different popularity levels. Experimental results on three public datasets show that A2G-DiffRec is effective in enhancing item-side fairness at a marginal cost of accuracy reduction compared to existing guided diffusion recommenders and other non-diffusion baselines.

cs.IR↗

arXiv2026

Understanding Secret Leakage Risks in Code LLMs: A Tokenization Perspective

Code secrets are sensitive assets for software developers, and their leakage poses significant cybersecurity risks. While the rapid development of AI code assistants powered by Code Large Language Models (CLLMs), CLLMs are shown to inadvertently leak such secrets due to a notorious memorization phenomenon. This study first reveals that Byte-Pair Encoding (BPE) tokenization leads to unexpected behavior of secret memorization, which we term as \textit{gibberish bias}. Specifically, we identified that some secrets are among the easiest for CLLMs to memorize. These secrets yield high character-level entropy, but low token-level entropy. Then, this paper supports the biased claim with numerical data. We identified that the roots of the bias are the token distribution shift between the CLLM training data and the secret data. We further discuss how gibberish bias manifests under the ``larger vocabulary'' trend. To conclude the paper, we discuss potential mitigation strategies and the broader implications on current tokenizer design.

cs.CR↗

arXiv2026

Low voltage and high-bandwidth thin-film lithium tantalate modulator on a silicon dioxide substrate

Modern communication networks demand ever-increasing transmission bandwidth, placing stringent requirements on low-cost, high-performance electro-optic modulators. Substantial advances have been made in integrated photonics employing lithium niobate on insulator. In contrast, photonic integrated circuits based on lithium tantalate -- a material already commercially adopted for wireless filters -- have been developed, offering reduced DC drift, higher optical power handling, and lower birefringence. These advantages enable more complex and dense photonic integrated circuits, and make lithium tantalate a promising material platform for next-generation integrated electro-optic modulators. However, in contrast to the extensively studied thin-film lithium niobate platform, thin-film lithium tantalate modulators have only been explored on silicon substrates. Here, we report the first fabrication and characterization of thin-film lithium tantalate electro-optic modulators manufactured on a 4-inch (100 mm) fused-silica substrate for adapting a low-loss slow-wave microwave electrode to improve the electro-optic bandwidth. By employing a slow-wave electrode design to achieve velocity matching between microwave and optical signals, the demonstrated modulator achieves a 3-dB electro-optic bandwidth of 64 GHz with a low half-wave voltage of 1.53 V, with potential to operate at the measured 100 GHz electrical bandwidth, if the employed spectral biasing is removed. The modulator moreover exhibits low bias drift, with a constant switching voltage down to 10 mHz. This performance enables high-speed data transmission comparable to state-of-the-art lithium niobate modulators fabricated on quartz substrates. Using the fabricated devices, a net single lane data rate of 440.6 Gbps is achieved using PAM8 signaling.

physics.optics↗