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Zihan Zang

Publications and source records attributed to Zihan Zang.

6 recordsLinked to original sources

High-speed optical microscopy for neural voltage imaging: Methods, trade-offs, and opportunities

High-speed optical imaging of dynamic neuronal activity is essential yet challenging in neuroscience. While calcium imaging has been firmly established as a workhorse technique for monitoring neuronal activity, its limited temporal resolution and indirect measurement restrict its ability to capture rapid inhibitory and excitatory events and subthreshold voltage oscillations. In contrast, voltage imaging directly measures membrane potential fluctuations, providing a comprehensive and precise representation of neuronal circuit dynamics. Recent advancements in voltage-sensitive dyes and, particularly, genetically encoded voltage indicators have significantly enhanced the feasibility of voltage imaging, prompting the development of advanced fluorescence microscopy methods optimized for high-speed acquisition. However, achieving millisecond-scale temporal resolution remains challenging due to inherent trade-offs among imaging speed, spatial resolution, and signal-to-noise ratio. Conventional raster-scanning approaches, including confocal microscopy, are fundamentally limited by their slow frame rates, precluding the capture of rapid neuronal events from multiple neurons simultaneously. Alternative techniques such as random-access scanning, spatiotemporal multiplexing, and computational optical imaging have successfully addressed these constraints, enabling kilohertz-level imaging of neuronal activity in both two-dimensional and three-dimensional contexts. This review summarizes recent progress in high-speed optical microscopy for voltage imaging and discusses its transformative potential for neuroscience research.

physics.optics

Content-Aware Foveated Camera for Multi-Target Tracking

Modern image sensors deliver substantial space-time bandwidth, yet indiscriminate acquisition often overwhelms memory, computation, and downstream perception. We present a content-aware, multi-foveated camera that dynamically reallocates sensing and magnification to multiple regions of interest (ROIs). A phase-only spatial light modulator (SLM) serves as a solid-state, inertia-free beam-steering and lens element, enabling per-frame field-of-view (FOV) reconfiguration and content-aware target tracking. By interleaving frames across foveae, our system preserves a wide-FOV situational context while refreshing each ROI at high rates, thereby reducing data volume without degrading task performance. We constructed a prototype employing single-SLM, single-sensor architecture and demonstrated its application in real-time multi-object tracking with dynamic ROI maintenance across multiple viewpoints. The approach offers a general pathway to integrate detection, tracking, and segmentation algorithms in the acquisition loop, shifting workload from post hoc processing to intelligent capture.

physics.optics

B-spline freeform surface tailoring for prescribed irradiance based on differentiable ray-tracing

A universal and flexible design method for freeform surface that can modulate the distribution of an zero-étendue source to an arbitrary irradiance distribution is a significant challenge in the field of non-imaging optics. Current design methods typically formulate the problem as a partial differential equation and solve it through sophisticated numerical methods, especially for off-axis situations. However, most of the current methods are unsuitable for directly solving multi-freeform surface or hybrid design problems that contains both freeform and spherical surfaces. To address these challenges, we propose the B-spline surface tailoring method, based on a differentiable ray-tracing algorithm. Our method features a computationally efficient B-spline model and a two-step optimization strategy based on optimal transport mapping. This allows for rapid, iterative adjustments to the surface shape based on deviations between the simulated and target distributions while ensuring a smooth resulting surface shape. In experiments, the proposed approach performs well in both paraxial and off-axis situations, and exhibits superior flexibility when applied to hybrid design case.

physics.optics

DAD vision: opto-electronic co-designed computer vision with division adjoint method

The miniaturization and mobility of computer vision systems are limited by the heavy computational burden and the size of optical lenses. Here, we propose to use a ultra-thin diffractive optical element to implement passive optical convolution. A division adjoint opto-electronic co-design method is also proposed. In our simulation experiments, the first few convolutional layers of the neural network can be replaced by optical convolution in a classification task on the CIFAR-10 dataset with no power consumption, while similar performance can be obtained.

cs.CV

Planar multi-aperture fish-eye lens using metagrating

The design of compact optical systems with large field of view has been difficult due to the requirement of many elements or a curved focal plane to reduce off-axis aberration. We propose a multi-aperture lens design to effectively resolve these issues. Metagrating-based deflectors are placed near entrance pupils of multi-aperture lens array to enhance field of view. A systematic design method is given in details. In design examples, a $\pm$80$^\circ$ field of view using only two planar optical elements is achieved. Also, the system is extremely compact with total track lengths an order of magnitude smaller than conventional fish-eye lenses, while the imaging performance is comparable with conventional designs.

physics.optics

Ultrafast Parallel LiDAR with Time-encoding and Spectral Scanning: Breaking the Time-of-flight Limit

Light detection and ranging (LiDAR) has been widely used in autonomous driving and large-scale manufacturing. Although state-of-the-art scanning LiDAR can perform long-range three-dimensional imaging, the frame rate is limited by both round-trip delay and the beam steering speed, hindering the development of high-speed autonomous vehicles. For hundred-meter level ranging applications, a several-time speedup is highly desirable. Here, we uniquely combine fiber-based encoders with wavelength-division multiplexing devices to implement all-optical time-encoding on the illumination light. Using this method, parallel detection and fast inertia-free spectral scanning can be achieved simultaneously with single-pixel detection. As a result, the frame rate of a scanning LiDAR can be multiplied with scalability. We demonstrate a 4.4-fold speedup for a maximum 75-m detection range, compared with a time-of-flight-limited laser ranging system. This approach has the potential to improve the velocity of LiDAR-based autonomous vehicles to the regime of hundred kilometers per hour and open up a new paradigm for ultrafast-frame-rate LiDAR imaging.

physics.optics