arXiv subjects

Zihao Jing

Publications and source records attributed to Zihao Jing.

9 recordsLinked to original sources

arXiv2026

Synthetic Data Alone is Enough? Rethinking Data Scarcity in Pediatric Rare Disease Recognition

Children with rare genetic diseases often exhibit distinctive facial phenotypes, yet developing computer vision systems for early diagnosis remains challenging due to extreme data scarcity, privacy constraints, and limited data sharing in pediatric settings. These challenges not only hinder automated diagnosis but also restrict the availability of visual resources for clinical genetic counseling. While prior work has shown that synthetic data can augment real datasets and preserve phenotype-level semantics, it remains unclear whether synthetic data alone is sufficient for learning in ultra-low-resource pediatric settings. In this work, we study the synthetic-only regime for pediatric rare disease recognition. Under a controlled experimental setup, models are trained exclusively on phenotype-aware synthetic facial images at increasing scales. We find that synthetic-only training achieves performance comparable to real-data-only baselines at sufficient scale across multiple backbones, suggesting that high-fidelity synthetic data can approximate clinically meaningful distributions. These findings together further enable the use of synthetic pediatric facial images as privacy-preserving resources for genetic education and counseling, supporting clinician training and patient communication. Our results highlight the potential of computer vision to improve data efficiency and expand accessible visual tools in children's healthcare.

cs.CV↗

arXiv2026

Distilling and Adapting: A Topology-Aware Framework for Zero-Shot Interaction Prediction in Multiplex Biological Networks

Multiplex Biological Networks (MBNs), which represent multiple interaction types between entities, are crucial for understanding complex biological systems. Yet, existing methods often inadequately model multiplexity, struggle to integrate structural and sequence information, and face difficulties in zero-shot prediction for unseen entities with no prior neighbourhood information. To address these limitations, we propose a novel framework for zero-shot interaction prediction in MBNs by leveraging context-aware representation learning and knowledge distillation. Our approach leverages domain-specific foundation models to generate enriched embeddings, introduces a topology-aware graph tokenizer to capture multiplexity and higher-order connectivity, and employs contrastive learning to align embeddings across modalities. A teacher-student distillation strategy further enables robust zero-shot generalization. Experimental results demonstrate that our framework outperforms state-of-the-art methods in interaction prediction for MBNs, providing a powerful tool for exploring various biological interactions and advancing personalized therapeutics.

cs.LG↗

arXiv2026

Pruning for Generalization: A Transfer-Oriented Spatiotemporal Graph Framework

Multivariate time series forecasting in graph-structured domains is critical for real-world applications, yet existing spatiotemporal models often suffer from performance degradation under data scarcity and cross-domain shifts. We address these challenges through the lens of structure-aware context selection. We propose TL-GPSTGN, a transfer-oriented spatiotemporal framework that enhances sample efficiency and out-of-distribution generalization by selectively pruning non-optimized graph context. Specifically, our method employs information-theoretic and correlation-based criteria to extract structurally informative subgraphs and features, resulting in a compact, semantically grounded representation. This optimized context is subsequently integrated into a spatiotemporal convolutional architecture to capture complex multivariate dynamics. Evaluations on large-scale traffic benchmarks demonstrate that TL-GPSTGN consistently outperforms baselines in low-data transfer scenarios. Our findings suggest that explicit context pruning serves as a powerful inductive bias for improving the robustness of graph-based forecasting models.

cs.LG↗

arXiv2026

Entropy-Guided Dynamic Tokens for Graph-LLM Alignment in Molecular Understanding

Molecular understanding is central to advancing areas such as scientific discovery, yet Large Language Models (LLMs) struggle to understand molecular graphs effectively. Existing graph-LLM bridges often adapt the Q-Former-style connector with fixed-length static tokens, which is originally designed for vision tasks. These designs overlook stereochemistry and substructural context and typically require costly LLM-backbone fine-tuning, limiting efficiency and generalization. We introduce EDT-Former, an Entropy-guided Dynamic Token Transformer that generates tokens aligned with informative molecular patches, thereby preserving both local and global structural features for molecular graph understanding. Beyond prior approaches, EDT-Former enables alignment between frozen graph encoders and LLMs without tuning the LLM backbone (excluding the embedding layer), resulting in computationally efficient finetuning, and achieves stateof-the-art results on MoleculeQA, Molecule-oriented Mol-Instructions, and property prediction benchmarks (TDC, MoleculeNet), underscoring its effectiveness for scalable and generalizable multimodal molecular understanding

cs.LG↗

arXiv2026

Scaling-Aware Adapter for Structure-Grounded LLM Reasoning

Large language models (LLMs) are enabling reasoning over 2D and 3D structures, yet existing methods remain modality-specific and typically compress structural inputs through sequence-based tokenization or fixed-length query connectors. Such architectures either omit the geometric grounding requisite for mitigating structural hallucinations, or impose inflexible modality fusion bottlenecks that concurrently over-compress and suboptimally allocate structural tokens, thereby impeding the realization of generalized all-atom reasoning. We introduce Cuttlefish, a unified multimodal LLM that grounds language reasoning in geometric cues while scaling modality tokens with structural complexity. First, Scaling-Aware Patching leverages an instruction-conditioned gating mechanism to generate variable-size patches over structural graphs, adaptively scaling the query token budget with structural complexity to mitigate fixed-length connector bottlenecks. Second, Geometry Grounding Adapter refines these adaptive tokens via cross-attention to modality embeddings and injects the resulting modality tokens into the LLM, exposing explicit geometric cues to reduce structural hallucination. Experiments across interdisciplinary all-atom benchmarks demonstrate that Cuttlefish achieves superior performance in heterogeneous structure-grounded reasoning. Code: github.com/zihao-jing/Cuttlefish.

cs.AI↗

arXiv2025

Structure-Aware Fusion with Progressive Injection for Multimodal Molecular Representation Learning

Multimodal molecular models often suffer from 3D conformer unreliability and modality collapse, limiting their robustness and generalization. We propose MuMo, a structured multimodal fusion framework that addresses these challenges in molecular representation through two key strategies. To reduce the instability of conformer-dependent fusion, we design a Structured Fusion Pipeline (SFP) that combines 2D topology and 3D geometry into a unified and stable structural prior. To mitigate modality collapse caused by naive fusion, we introduce a Progressive Injection (PI) mechanism that asymmetrically integrates this prior into the sequence stream, preserving modality-specific modeling while enabling cross-modal enrichment. Built on a state space backbone, MuMo supports long-range dependency modeling and robust information propagation. Across 29 benchmark tasks from Therapeutics Data Commons (TDC) and MoleculeNet, MuMo achieves an average improvement of 2.7% over the best-performing baseline on each task, ranking first on 22 of them, including a 27% improvement on the LD50 task. These results validate its robustness to 3D conformer noise and the effectiveness of multimodal fusion in molecular representation. The code is available at: github.com/selmiss/MuMo.

cs.LG↗

arXiv2025

MolGraph-xLSTM: A graph-based dual-level xLSTM framework with multi-head mixture-of-experts for enhanced molecular representation and interpretability

Predicting molecular properties is essential for drug discovery, and computational methods can greatly enhance this process. Molecular graphs have become a focus for representation learning, with Graph Neural Networks (GNNs) widely used. However, GNNs often struggle with capturing long-range dependencies. To address this, we propose MolGraph-xLSTM, a novel graph-based xLSTM model that enhances feature extraction and effectively models molecule long-range interactions. Our approach processes molecular graphs at two scales: atom-level and motif-level. For atom-level graphs, a GNN-based xLSTM framework with jumping knowledge extracts local features and aggregates multilayer information to capture both local and global patterns effectively. Motif-level graphs provide complementary structural information for a broader molecular view. Embeddings from both scales are refined via a multi-head mixture of experts (MHMoE), further enhancing expressiveness and performance. We validate MolGraph-xLSTM on 10 molecular property prediction datasets, covering both classification and regression tasks. Our model demonstrates consistent performance across all datasets, with improvements of up to 7.03% on the BBBP dataset for classification and 7.54% on the ESOL dataset for regression compared to baselines. On average, MolGraph-xLSTM achieves an AUROC improvement of 3.18\% for classification tasks and an RMSE reduction of 3.83\% across regression datasets compared to the baseline methods. These results confirm the effectiveness of our model, offering a promising solution for molecular representation learning for drug discovery.

cs.LG↗

arXiv2024

Graph Pruning Based Spatial and Temporal Graph Convolutional Network with Transfer Learning for Traffic Prediction

With the process of urbanization and the rapid growth of population, the issue of traffic congestion has become an increasingly critical concern. Intelligent transportation systems heavily rely on real-time and precise prediction algorithms to address this problem. While Recurrent Neural Network (RNN) and Graph Convolutional Network (GCN) methods in deep learning have demonstrated high accuracy in predicting road conditions when sufficient data is available, forecasting in road networks with limited data remains a challenging task. This study proposed a novel Spatial-temporal Convolutional Network (TL-GPSTGN) based on graph pruning and transfer learning framework to tackle this issue. Firstly, the essential structure and information of the graph are extracted by analyzing the correlation and information entropy of the road network structure and feature data. By utilizing graph pruning techniques, the adjacency matrix of the graph and the input feature data are processed, resulting in a significant improvement in the model's migration performance. Subsequently, the well-characterized data are inputted into the spatial-temporal graph convolutional network to capture the spatial-temporal relationships and make predictions regarding the road conditions. Furthermore, this study conducts comprehensive testing and validation of the TL-GPSTGN method on real datasets, comparing its prediction performance against other commonly used models under identical conditions. The results demonstrate the exceptional predictive accuracy of TL-GPSTGN on a single dataset, as well as its robust migration performance across different datasets.

cs.AI↗

arXiv2024

Piccolo2: General Text Embedding with Multi-task Hybrid Loss Training

In this report, we introduce Piccolo2, an embedding model that surpasses other models in the comprehensive evaluation over 6 tasks on CMTEB benchmark, setting a new state-of-the-art. Piccolo2 primarily leverages an efficient multi-task hybrid loss training approach, effectively harnessing textual data and labels from diverse downstream tasks. In addition, Piccolo2 scales up the embedding dimension and uses MRL training to support more flexible vector dimensions. The latest information of piccolo models can be accessed via: https://huggingface.co/sensenova/

cs.CL↗