arXiv subjects

Ziqi Kang

Publications and source records attributed to Ziqi Kang.

4 recordsLinked to original sources

arXiv2025

Progress and new challenges in image-based profiling

For over two decades, image-based profiling has revolutionized cell phenotype analysis. Image-based profiling processes rich, high-throughput, microscopy data into thousands of unbiased measurements that reveal phenotypic patterns powerful for drug discovery, functional genomics, and cell state classification. Here, we review the evolving computational landscape of image-based profiling, detailing the bioinformatics processes involved from feature extraction to normalization and batch correction. We discuss how deep learning has fundamentally reshaped the field. We examine key methodological advancements, such as single-cell analysis, the development of robust similarity metrics, and the expansion into new modalities like optical pooled screening, temporal imaging, and 3D organoid profiling. We also highlight the growth of public benchmarks and open-source software ecosystems as a key driver for fostering reproducibility and collaboration. Despite these advances, the field still faces substantial challenges, particularly in developing methods for emerging temporal and 3D data modalities, establishing robust quality control standards and workflows, and interpreting the processed features. By focusing on the technical evolution of image-based profiling rather than the wide-ranging biological applications, our aim with this review is to provide researchers with a roadmap for navigating the progress and new challenges in this rapidly advancing domain.

q-bio.QM↗

arXiv2025

Quantum Benchmarking of High-Fidelity Noise-Biased Operations on a Detuned-Kerr-Cat Qubit

Ubiquitous noises in quantum systems remain a key obstacle to building quantum computers, necessitating the use of quantum error correction codes. Recently, error-correcting codes tailored for noise-biased systems have been shown to offer high fault-tolerance thresholds and reduced hardware overhead, positioning noise-biased qubits as promising candidates for building universal quantum computers. However, quantum operations on these platforms remain challenging, and their noise structures have not yet been rigorously benchmarked to the same extent as those of conventional quantum hardware. In this work, we develop a comprehensive quantum control toolbox for a scalable noise-biased qubit, detuned Kerr-cat qubit, including initialization, universal single-qubit gates and quantum non-demolition readout. We systematically characterize the noise structure of these operations using gate set tomography and dihedral randomized benchmarking, achieving high local gate fidelities, with $\mathcal{F}[Z(π/2)]=99.2\%$ and $\mathcal{F}[X(π/2)]=92.5\%$. Notably, the noise bias of the detuned Kerr-cat qubit approaches 250, which outperforms its resonant-Kerr-cat qubit counterparts as reported previously, representing a new state-of-the-art performance benchmark for noise-biased qubits. Moreover, our results reveal a critical overestimation of operational noise bias inferred from bit-flip and phase-flip times alone, highlighting the necessity of a precise and direct benchmarking for noise-biased qubit operations. Our work thus establishes a framework for systematically characterizing and validating the performance of quantum operations in structured-noise architectures, which lays the groundwork for implementing efficient quantum error correction in next-generation architectures.

quant-ph↗

arXiv2025

Scalable and Site-Specific Frequency Tuning of Two-Level System Defects in Superconducting Qubit Arrays

State-of-the-art superconducting quantum processors containing tens to hundreds of qubits have demonstrated the building blocks for realizing fault-tolerant quantum computation. Nonetheless, a fundamental barrier to scaling further is the prevalence of fluctuating quantum two-level system (TLS) defects that can couple resonantly to qubits, causing excess decoherence and enhanced gate errors. Here we introduce a scalable architecture for site-specific and in-situ manipulation of TLS frequencies out of the spectral vicinity of our qubits. Our method is resource efficient, combining TLS frequency tuning and universal single qubit control into a single on-chip control line per qubit. We independently control each qubit's dissipative environment to dynamically improve both qubit coherence times and single qubit gate fidelities -- with a constant time overhead that does not scale with the device size. Over a period of 40 hours across 6 qubits, we demonstrate a $36\%$ improvement in average single qubit error rates and a $17\%$ improvement in average energy relaxation times. Critically, we realize a 4-fold suppression in the occurrence of TLS-induced performance outliers, and a complete reduction of simultaneous outlier events. These results mark a significant step toward overcoming the challenges that TLS defects pose to scaling superconducting quantum processors.

quant-ph↗

arXiv2024

High-Coherence Kerr-cat qubit in 2D architecture

The Kerr-cat qubit is a bosonic qubit in which multi-photon Schrodinger cat states are stabilized by applying a two-photon drive to an oscillator with a Kerr nonlinearity. The suppressed bit-flip rate with increasing cat size makes this qubit a promising candidate to implement quantum error correction codes tailored for noise-biased qubits. However, achieving strong light-matter interactions necessary for stabilizing and controlling this qubit has traditionally required strong microwave drives that heat the qubit and degrade its performance. In contrast, increasing the coupling to the drive port removes the need for strong drives at the expense of large Purcell decay. By integrating an effective band-block filter on-chip, we overcome this trade-off and realize a Kerr-cat qubit in a scalable 2D superconducting circuit with high coherence. This filter provides 30 dB of isolation at the qubit frequency with negligible attenuation at the frequencies required for stabilization and readout. We experimentally demonstrate quantum non-demolition readout fidelity of 99.6% for a cat with 8 photons. Also, to have high-fidelity universal control over this qubit, we combine fast Rabi oscillations with a new demonstration of the X(90) gate through phase modulation of the stabilization drive. Finally, the lifetime in this architecture is examined as a function of the cat size of up to 10 photons in the oscillator achieving a bit-flip time higher than 1 ms and only a linear decrease in the phase-flip time, in good agreement with the theoretical analysis of the circuit. Our qubit shows promise as a building block for fault-tolerant quantum processors with a small footprint.

quant-ph↗