arXiv subjects

Zixuan Zhao

Publications and source records attributed to Zixuan Zhao.

14 recordsLinked to original sources

arXiv2026

Discretization in covariate-adaptive randomization: gains and losses

Covariate-adaptive randomization(CAR) is widely implemented in clinical trials to balance prognostic covariates across treatment arms. Continuous covariates are often discretized into strata in practice, yet their consequences are not clearly understood. This paper provides a comprehensive study of the impact of discretization on both the CAR design process and the inferential results thereafter. We establish the asymptotic properties of both imbalance measures and treatment effect estimators under discretized and non-discretized settings. Practical recommendations are given on when and how discretization should be employed. We show that discretization in design is generally recommended, as it enhances robustness against model misspecification. However, if the true model is known, the most efficient strategy is to balance covariates according to that model in the design. The theoretical results are corroborated by extensive simulation studies and an empirical application to a diabetes trial dataset. Together, the results clarify the gains and losses of discretization in CAR and pave the way for learning impact of discretization to other designs and beyond.

stat.ME↗

arXiv2026

SynthIPD: training-free synthetic individual patient data generation

Individual patient data (IPD) are essential for statistical inference in clinical research. However, privacy concerns, high data-sharing costs, and restrictive access often make IPD unavailable. Conventional synthetic data generation usually relies on black box models such as generative adversial networks. These methods, however, requires a large piece of IPD for model training, may be ungeneralizable and lacks interpretability. This paper introduces an assumption-lean, three-step methodology for generating synthetic IPD with survival endpoints only based on published clinical trial articles. The method mainly leverages Kaplan-Meier (KM) curves with at-risk/censoring information and subgroup-level summary statistics. It digitizes the KM curve using Scalable Vector Graphics (SVG) beyond pixel accuracy and then generates synthetic covariates based on the statistics. We illustrate the method's potential through $2$ detailed case studies and simulation studies. The method offers important implications, enabling high-fidelity IPD generation to support evidence-based medical decisions.

stat.AP↗

arXiv2026

Systematic Literature Reviews With Two Multi-Agentic Systems And Human-In-The-Loop

Systematic literature review of clinical trials drives regulatory decision-making, but conventional screening and extraction are time-consuming, labor-intensive, and vulnerable to study selection bias. We propose two fit-to-purpose multi-agentic systems (MAS) for systematic literature review, with human-in-the-loop. The screening MAS uses multiple LLM agents with heterogeneous personas and multiround cross-review, and uniformly improves accuracy over a single-LLM baseline. The extraction MAS combines standardization, an iterative correction loop, and retrieval-based context control to ensure accuracy and scalability. Both MAS are specifically designed to support Human-In-The-Loop which is essential for clinical decisions. The novelty of the proposed approach lies in the system architecture rather than in any single foundation tools: the system can naturally benefit from future improvements in the underlying tools, for instance, stronger LLM agents, retrieval engines, image recognition methods, etc. As a real-world application, a published network meta-analysis is reproduced by the MAS. The result recovers all trials from the original study and identifies additional eligible trials missed by manual review, leading to updated clinical conclusions.

stat.AP↗

arXiv2026

Dual Prototype-Conditioned Diffusion Model for Scalable Multi-Class Unsupervised Anomaly Detection in Large Category Spaces

Multi-class anomaly detection aims to build unified models across diverse product categories. However, as the number of categories grows, its performance often degrades due to increasingly complex and heterogeneous normal distributions. To address this challenge, we propose DPDiff-AD, a Dual Prototype-conditioned Diffusion model for large-scale multi-class Anomaly Detection. DPDiff-AD models heterogeneous normal distributions through complementary local and global prototypes. Local prototypes capture representative fine-grained structural patterns via nearest-prototype aggregation, while global prototypes regulate holistic feature geometry through optimal transport regularization. Together, these dual-scale representations define a structured normality space. This space is refined through diffusion-based reconstruction conditioned on both local and global prototypes via prototype-aware attention. By jointly leveraging dual prototypes during generation, DPDiff-AD achieves precise normality modeling, preserves structured separability as category cardinality grows, and enables scalable anomaly discrimination. Extensive experiments across five benchmarks demonstrate the effectiveness and scalability of DPDiff-AD. On the 160-category large-scale dataset, it improves image- and pixel-level AUROC by 5.3 and 2.9 points over the previous state-of-the-art method Dinomaly+, while maintaining stable performance as category cardinality increases.

cs.CV↗

arXiv2026

Intuitive Surgical SurgToolLoc and SurgVU Challenges Results: 2022-2025

Robotic assisted (RA) surgery promises to transform surgical intervention. Intuitive Surgical is committed to fostering these changes and the machine learning models and algorithms that will enable them. With these goals in mind we have invited the surgical data science community to participate in a yearly competition hosted through the Medical Imaging Computing and Computer Assisted Interventions (MICCAI) conference. With varying changes from year to year, we have challenged the community to solve difficult machine learning problems in the context of advanced RA applications. Here we document the results of these challenges, focusing on surgical tool localization (SurgToolLoc) and surgical visual understanding (SurgVU). The publicly released dataset that accompanies these challenges is detailed in a separate paper arXiv:2501.09209 [1].

cs.CV↗

arXiv2026

Img2CADSeq: Image-to-CAD Generation via Sequence-Based Diffusion

Boundary Representation (BRep) is the standard format for Computer-Aided Design (CAD), yet reconstructing high-quality BReps from single-view images remains challenging due to the complexity of topological constraints and operation sequences. We present Img2CADSeq, a multi-stage pipeline that overcomes these limitations by encoding CAD sequences into a three-level hierarchical codebook. Guided by an importance prioritization, this strategy values profiles over details, compressing long sequences into a stable discrete latent space. To bridge the modality gap, we leverage a coarse-to-fine point cloud intermediate, aligning 2D visual features with 3D CAD sequences via contrastive learning to condition a VQ-Diffusion model. Supported by newly introduced CAD-220K and PrintCAD datasets, our approach ensures robust industrial domain adaptation. Extensive experiments demonstrate that Img2CADSeq significantly outperforms state-of-the-art methods, producing standard STEP files that can be directly used in commercial CAD software.

cs.CV↗

arXiv2025

Pseudo-Measurement Enhancement in Power Distribution Systems

With the rapid development of smart distribution networks (DNs), the integrity and accuracy of grid measurement data are crucial to the safety and stability of the entire system. However, the quality of the user power consumption data cannot be guaranteed during the collection and transmission process. To this end, this paper proposes a low-rank tensor completion model based on CANDECOMP/PARAFAC decomposition (CPD-LRTC) to enhance the quality of the measurement data of the DNs. Firstly, the causes and the associated characteristics of the missing data are analyzed, and a third-order standard tensor is constructed as a mathematical model of the measurement data of the DN. Then, a completion model is established based on the characteristics of measurement data and the low rank of the completion tensor, and the alternating direction method of multipliers (ADMM) is used to solve it iteratively. Finally, the proposed model is verified through two case studies, the completion accuracy, the computational efficiency, and the memory usage are compared to traditional methods.

eess.SY↗

arXiv2024

Continual Learning in the Presence of Repetition

Continual learning (CL) provides a framework for training models in ever-evolving environments. Although re-occurrence of previously seen objects or tasks is common in real-world problems, the concept of repetition in the data stream is not often considered in standard benchmarks for CL. Unlike with the rehearsal mechanism in buffer-based strategies, where sample repetition is controlled by the strategy, repetition in the data stream naturally stems from the environment. This report provides a summary of the CLVision challenge at CVPR 2023, which focused on the topic of repetition in class-incremental learning. The report initially outlines the challenge objective and then describes three solutions proposed by finalist teams that aim to effectively exploit the repetition in the stream to learn continually. The experimental results from the challenge highlight the effectiveness of ensemble-based solutions that employ multiple versions of similar modules, each trained on different but overlapping subsets of classes. This report underscores the transformative potential of taking a different perspective in CL by employing repetition in the data stream to foster innovative strategy design.

cs.LG↗

arXiv2024

Subtoxic Questions: Dive Into Attitude Change of LLM's Response in Jailbreak Attempts

As Large Language Models (LLMs) of Prompt Jailbreaking are getting more and more attention, it is of great significance to raise a generalized research paradigm to evaluate attack strengths and a basic model to conduct subtler experiments. In this paper, we propose a novel approach by focusing on a set of target questions that are inherently more sensitive to jailbreak prompts, aiming to circumvent the limitations posed by enhanced LLM security. Through designing and analyzing these sensitive questions, this paper reveals a more effective method of identifying vulnerabilities in LLMs, thereby contributing to the advancement of LLM security. This research not only challenges existing jailbreaking methodologies but also fortifies LLMs against potential exploits.

cs.CR↗

arXiv2023

Consistent Covariance estimation for stratum imbalances under minimization method for covariate-adaptive randomization

Pocock and Simon's minimization method is a popular approach for covariate-adaptive randomization in clinical trials. Valid statistical inference with data collected under the minimization method requires the knowledge of the limiting covariance matrix of within-stratum imbalances, whose existence is only recently established. In this work, we propose a bootstrap-based estimator for this limit and establish its consistency, in particular, by Le Cam's third lemma. As an application, we consider in simulation studies adjustments to existing robust tests for treatment effects with survival data by the proposed estimator. It shows that the adjusted tests achieve a size close to the nominal level, and unlike other designs, the robust tests without adjustment may have an asymptotic size inflation issue under the minimization method.

stat.ME↗

arXiv2022

CholecTriplet2021: A benchmark challenge for surgical action triplet recognition

Context-aware decision support in the operating room can foster surgical safety and efficiency by leveraging real-time feedback from surgical workflow analysis. Most existing works recognize surgical activities at a coarse-grained level, such as phases, steps or events, leaving out fine-grained interaction details about the surgical activity; yet those are needed for more helpful AI assistance in the operating room. Recognizing surgical actions as triplets of combination delivers comprehensive details about the activities taking place in surgical videos. This paper presents CholecTriplet2021: an endoscopic vision challenge organized at MICCAI 2021 for the recognition of surgical action triplets in laparoscopic videos. The challenge granted private access to the large-scale CholecT50 dataset, which is annotated with action triplet information. In this paper, we present the challenge setup and assessment of the state-of-the-art deep learning methods proposed by the participants during the challenge. A total of 4 baseline methods from the challenge organizers and 19 new deep learning algorithms by competing teams are presented to recognize surgical action triplets directly from surgical videos, achieving mean average precision (mAP) ranging from 4.2% to 38.1%. This study also analyzes the significance of the results obtained by the presented approaches, performs a thorough methodological comparison between them, in-depth result analysis, and proposes a novel ensemble method for enhanced recognition. Our analysis shows that surgical workflow analysis is not yet solved, and also highlights interesting directions for future research on fine-grained surgical activity recognition which is of utmost importance for the development of AI in surgery.

cs.CV↗

arXiv2021

Neko: a Library for Exploring Neuromorphic Learning Rules

The field of neuromorphic computing is in a period of active exploration. While many tools have been developed to simulate neuronal dynamics or convert deep networks to spiking models, general software libraries for learning rules remain underexplored. This is partly due to the diverse, challenging nature of efforts to design new learning rules, which range from encoding methods to gradient approximations, from population approaches that mimic the Bayesian brain to constrained learning algorithms deployed on memristor crossbars. To address this gap, we present Neko, a modular, extensible library with a focus on aiding the design of new learning algorithms. We demonstrate the utility of Neko in three exemplar cases: online local learning, probabilistic learning, and analog on-device learning. Our results show that Neko can replicate the state-of-the-art algorithms and, in one case, lead to significant outperformance in accuracy and speed. Further, it offers tools including gradient comparison that can help develop new algorithmic variants. Neko is an open source Python library that supports PyTorch and TensorFlow backends.

cs.LG↗

arXiv2020

Full Daytime Sub-ambient Radiative Cooling with High Figure of Merit in Commercial-like Paints

Radiative cooling is a passive cooling technology by reflecting sunlight and emitting radiation in the atmospheric sky window. Although highly desired, full daytime sub-ambient radiative cooling in commercial-like single-layer particle-matrix paints is yet to be achieved. In this work, we have demonstrated full daytime sub-ambient radiative cooling in CaCO3-acrylic paint by adopting large bandgap fillers, a high particle concentration and a broad size distribution. Our paint shows the highest solar reflectance of 95.5% among paints and a high sky-window emissivity of 0.94. Field tests show cooling power exceeding 37 W/m2 and lower surface temperature more than 1.7C below ambient at noon. A figure of merit RC is proposed to compare the cooling performance under different weather conditions. The RC of our cooling paint is 0.62, among the best radiative cooling performance while offering unprecedented benefits of the convenient paint form, low cost, and the compatibility with commercial paint fabrication process.

physics.app-ph↗

arXiv2020

Recurrent and Spiking Modeling of Sparse Surgical Kinematics

Robot-assisted minimally invasive surgery is improving surgeon performance and patient outcomes. This innovation is also turning what has been a subjective practice into motion sequences that can be precisely measured. A growing number of studies have used machine learning to analyze video and kinematic data captured from surgical robots. In these studies, models are typically trained on benchmark datasets for representative surgical tasks to assess surgeon skill levels. While they have shown that novices and experts can be accurately classified, it is not clear whether machine learning can separate highly proficient surgeons from one another, especially without video data. In this study, we explore the possibility of using only kinematic data to predict surgeons of similar skill levels. We focus on a new dataset created from surgical exercises on a simulation device for skill training. A simple, efficient encoding scheme was devised to encode kinematic sequences so that they were amenable to edge learning. We report that it is possible to identify surgical fellows receiving near perfect scores in the simulation exercises based on their motion characteristics alone. Further, our model could be converted to a spiking neural network to train and infer on the Nengo simulation framework with no loss in accuracy. Overall, this study suggests that building neuromorphic models from sparse motion features may be a potentially useful strategy for identifying surgeons and gestures with chips deployed on robotic systems to offer adaptive assistance during surgery and training with additional latency and privacy benefits.

cs.CV↗