arXiv subjects

Ziyang Ling

Publications and source records attributed to Ziyang Ling.

7 recordsLinked to original sources

arXiv2026

FGSS-BO: Feedback-Guided Hypothesis Management for LLM-Based Bayesian Optimization

Large language model (LLM)-guided Bayesian optimization (BO) uses past observations to guide search, but proposed directions and their revision can remain implicit. We propose Feedback-Guided Search State (FGSS), a structured hypothesis-management interface connecting language-based guidance to observed evidence, executable parameter interventions, and comparative support updates. An LLM reflector proposes and revises hypotheses; a deterministic curator validates them and maintains identities and test records. The evolving state guides candidate construction and priorities. Instantiated on LLAMBO, FGSS-BO retains its surrogate and default expected improvement selection, with a bounded testing policy. On two retrospective protocol/media tasks with nearest-neighbor response oracles, it attains higher sample mean final best and search AUC than the matched LLAMBO baseline and evaluated non-LLM baselines. Prose-reflection and EI-only controls show mixed component effects. Six direct-training hyperparameter-optimization tasks show task-dependent transfer, strongest on diabetes SVM; exact-grid and reaction controls examine other settings. FGSS exposes hypotheses, their execution, and cross-round revisions for inspection while supporting search gains in selected settings.

cs.CL↗

arXiv2026

BioPRM: Step-Level Consistency Verification of Biological Protocols

Process reward models (PRMs) provide fine-grained supervision for assessing intermediate steps in language-model outputs, but their application to biological protocols presents distinct challenges. Protocol validity depends on both the appropriateness of individual operations and their consistency with the experimental objective and surrounding procedure, while experimental outcomes are typically unavailable during verification. We introduce BioPRM, a contextual process reward model for identifying procedural inconsistencies in structured biological protocols. We construct a supervision corpus from SciRecipe and protocols collected from protocols.io and Bio-protocol using LLM-assisted construction and source-specific review by personnel with biological expertise.

cs.CE↗

arXiv2026

Beyond Reachability: A Relation-Semantic Reasoning Framework for Biomedical Multi-hop QA

Biomedical multi-hop reasoning over knowledge graphs requires identifying a semantically valid relation sequence that supports the answer. Existing methods can retrieve correct answers, yet often rank them poorly within a large pool of seemingly relevant candidates. Even when a correct answer is retrieved, its associated evidence and reasoning path may fail to support the relation composition required by the question. We term this disconnect between answer reachability and evidential validity the reachable-but-invalid problem. We present ReSemReason, which shares a question-induced distribution over typed, directed relation schemas between candidate discovery and evidence selection. Schema compatibility guides graph search; ReSemAttn then uses relation-conditioned key/value projections and an uncertainty-weighted path prior to attend to candidate-specific evidence. A separate absolute-support score complements normalized attention when all retrieved paths are weak. The reported experiments on BioHopR, PrimeKGQA, and MedReason show improvements in answer ranking and answer-set quality. Path-discrimination analyses examine the distinction between endpoint correctness and evidential support. We also specify matched controls for search, attention, and schema uncertainty.

cs.CL↗

arXiv2026

PRISMATIC : Prescription Risk Inspection System for Multi-Agent Treatment Interaction in Clinical Decision-Making

Medical prescribing errors for multimorbid patients, who require complex drug regimens, are a major patient safety concern. These errors often stem from fragmented decision-making across medical specialties, a critical coordination failure that leads to adverse drug events and rehospitalizations. To address this coordination challenge, we introduce PRISMATIC, a multi-agent architecture where specialized agents, each representing a workflow role, collaboratively generate and refine treatment plans. Operating on a blackboard architecture, the system first structures patient information from clinical notes, then iteratively develops safe, rational, and interpretable drug regimens. The agents' collaboration is governed by two novel adaptive coordination mechanisms: (1) Dynamic Self-Updating Weight Adjustment (DSWA), a long-term mechanism that adjusts the influence weights of agents based on historical case outcomes, enabling the system to adapt and trust more reliable specialists over time. (2) Discrepancy Feedback Precise Calibration (DFPC), a short-term mechanism where agents provide iterative feedback to resolve disagreements and eliminate prescription conflicts for the current patient. Experiments on patient records from the MIMIC-IV database show that PRISMATIC significantly reduces drug conflicts, improves prescription coverage, and enhances treatment consistency compared to strong LLM baselines. Our work demonstrates that structuring clinical co-treatment as a multi-agent coordination problem offers a promising path toward safer and more coherent multidisease management.

cs.CL↗

arXiv2026

From Hindsight to Foresight: Dissecting Clinical Evidence Acquisition in Large Language Models

Large language models (LLMs) often diagnose full sight, static clinical cases well yet struggle in foresight, dynamic diagnosis. Prior work has improved this limitation by quantifying the information models acquire and by developing stronger follow-up strategies to improve diagnostic accuracy. In contrast, we introduce a distinctive hindsight to systematically dissect why LLMs fail to acquire diagnostically critical evidence, tracing the failure from evidence identification, utilization and downstream diagnostic updating through not only diagnostic accuracy, but also evidence coverage, trajectory dynamics, and elicited probability and information entropy. Starting experiments from the breakdown at the level of capabilities, to the diagnosis of the pre-event state before the evidence arrives, and to the post-event state transition after the evidence arrives, our research has revealed the profound limitations and internal causes existing in the dynamic diagnostic process. At the same time, we have also conducted sufficient verification and generalization experiments to prove that these limitations are widespread. Together, these findings shift the central challenge from whether LLMs possess relevant clinical knowledge to whether they can identify, acquire, and effectively use the right evidence under clinical diagnosis and conduct a more detailed mechanism analysis to identify the exact location of the capability gap.

cs.CL↗

arXiv2026

Training-Free BioNEL-RAG: Advancing Biomedical Entity Linking through Retrieval-Augmented Generation and Large Language Model

Biomedical Named Entity Linking (BioNEL) is the task of mapping mentions extracted from biomedical texts to canonical entities or concepts in the standardized knowledge base. Although existing methods have achieved remarkable performance in mapping accuracy, most rely on training with domain-specific datasets, which fundamentally limits their cross-domain adaptability. To address this limitation, we propose BioNEL-RAG, a novel training-free framework that combines retrieval-augmented generation (RAG) with large language models (LLMs). Within this framework, the RAG module focuses on retrieving candidate entities, while the large language model module plays the role of selecting the most appropriate candidate for entity normalization, which is based on the analysis of the mention's context, with the aid of its remarkable text comprehension capabilities. Experimental results demonstrate that BioNEL-RAG achieves performance comparable to existing methods without requiring training on subdomain datasets, whereas these methods necessitate fine-tuning on specific subdomains such as genes, diseases, or chemical compounds.

cs.CL↗

arXiv2026

THOR: A Theta-Gamma Hierarchical Oscillatory Reasoning Framework for Multi-hop QA

Multi-hop question answering requires retrieving and integrating evidence from multiple contexts. Despite the rapid progress of current research, multi-hop reasoning remains constrained by two persistent limitations: attention decay, where the model's focus on main question degrades as the reasoning chain grows, and error accumulation, where mistakes propagate across hops and compounds into final failure. Inspired by Theta-Gamma hierarchical oscillation which decouples global planning from local retrieval, enabling efficient attention transfer between hops and a verification and repair mechanism that interrupts the accumulation of errors in the wrong paths, we present THOR, a brain-inspired Theta-Gamma hierarchical oscillatory reasoning framework. Extensive comparative experiments and specific validation experiments on multi-hop QA benchmarks demonstrate that THOR improves answer accuracy and robustness while mitigating limitations, showcasing its generalization across different backbones.

cs.CL↗