arXiv subjects

Ziyue Zhang

Publications and source records attributed to Ziyue Zhang.

At least 19 recordsLinked to original sources

arXiv2026

MIRCID: Inferred Hub-miRNAs Drive Cross-Task Improvements in Drug Mechanistic Modeling

Drug mechanism-of-action (MoA) modeling commonly relies on perturbational transcriptomes, but matched microRNA (miRNA) measurements are often unavailable. Inferred regulatory features offer a scalable way to reuse these data. Here, we present MIRCID, a framework comparing gene expression with inferred transcription factor (TF) activity and miRNA expression across pathway classification and similarity-based MoA retrieval. HubmiRNet infers 414 pan-cancer hub miRNAs (HubmiRs) from 977 L1000 landmark genes, achieving a Pearson correlation coefficient of 87.72\%; its 1,298-output variant also outperformed SiCmiR on the full-miRNA task (71.21\% versus 67.30\%). In the evaluated comparisons, miRNA augmentation provided more consistent gains than TF activity. Generic embedding controls showed model-dependent utility, while complementarity analyses identified a distinct, partially linearly recoverable representation that retained gene-derived structure. Illustrative rescue cases linked improved classification to biologically plausible miRNA patterns in samples with weak transcriptional signatures. These findings support inferred HubmiRs as a biologically informed recoding of transcriptomic data for perturbational drug modeling, while leaving recovery of measured perturbational miRNA responses to further validation.

cs.LG↗

arXiv2026

Retrieve in Time, Correct in Frequency

Frozen vision-language-action (VLA) policies generate temporally extended action chunks, but long-horizon manipulation remains vulnerable to accumulated execution error and visual aliasing across task stages. Successful rollouts provide useful corrective evidence, yet current frame retrieval can return progress-misaligned actions,while direct replay or time-domain fusion can overwrite the reactive structure of the policy proposal. We introduce Retrieve in Time, Correct in Frequency (RTCF), a training-free test-time correction framework that improves frozen VLA performance with low model-side overhead.RTCF separates which experience to retrieve from which part of its action to transfer. Progressive Memory Alignment (PMA) causally aligns the growing visual execution history with complete successful trajectories through incrementally updated monotonic frontiers, jointly identifying a relevant memory and the current aligned memory position without stage labels. From the aligned action chunk,RTCF transfers a coefficient-wise-clipped low-frequency residual on motion channels. Higher-frequency components and gripper decisions remain inherited from the frozen policy. Across four LIBERO suites and 2,000 episodes per condition, RTCF raises aggregate success from 86.4% to 88.4% and improves LIBERO-Long from 61.6% to 68.6%.These gains require no parameter updates, repeated VLA inference, or additional GPU resources: correction can be performed on the client CPU after a single policy invocation, and the median latencies sum to only 10.99 ms per action chunk

cs.RO↗

arXiv2026

Beyond Supervised Clarification: Input Rewriting with LLMs for Dialogue Discourse Parsing

Rewriting inputs to improve frozen downstream models has become a common strategy in modern NLP pipelines. Prior work on incremental dialogue discourse parsing (DDP) shows that supervised clarification models can rewrite fragmentary or underspecified utterances, such as resolving ellipsis or references, to improve parsing accuracy. In this work, we revisit this idea under realistic deployment conditions, where no clarification supervision is available and the clarifier must rely on zero-shot prompting or feedback from a frozen parser. Across three Segmented Discourse Representation Theory (SDRT) datasets and multiple parsers, we find that last-utterance clarification is far less reliable than suggested by supervised settings. Parser-agnostic rewriting often introduces more regressions than repairs, as edits that enable fixes also disrupt discourse cues relied upon by the parser. A best-of-8 rewriting analysis further reveals a practical ceiling: a large fraction of errors are not repairable through input rewriting alone. A parser-aware clarifier trained with GRPO reduces regressions by up to 37% by learning conservative abstention, yet still fails to produce selectivity-aware clarifications that consistently improve parsing. Together, these findings recast clarification as a selective intervention problem. We identify rewritability prediction, deciding whether an utterance is repairable before intervention, as the key missing capability for input-side optimization of frozen discourse parsers, and a critical direction for improving agentic pipelines more broadly.

cs.CL↗

arXiv2026

EVA: Accelerating LLM Decoding via an Efficient Vector Quantization Architecture

Large Language Models (LLMs) have achieved impressive performance across diverse domains but remain inefficient during the autoregressive decoding phase. Unlike the prefill stage, which employs compute-bound GEMM operations, decoding executes a sequence of small GEMV-like computations that are memory-bound and underutilize modern accelerators. Weight-only vector quantization (VQ) has emerged as an effective compression technique that clusters model weights into a shared codebook and replaces the original weight matrix with low-precision indices, enabling 2-bit-level weight compression. While this approach substantially reduces model size and memory bandwidth, it still suffers from two critical inefficiencies: the low utilization of GEMV computation and frequent memory conflicts during codebook lookups. This paper presents EVA, an efficient vector-quantization-based architecture that addresses both computational and memory bottlenecks in LLM decoding. EVA builds on a simple yet effective insight that combines input-codebook computation with conflict-free memory access. Instead of reconstructing quantized weights from indices, EVA directly performs dot products between input vectors and the weight codebook, transforming LLM decoding from GEMV to GEMM computation. It then performs structured lookups from an intermediate output buffer, eliminating memory bank conflicts. We further design a hardware-software co-optimized architecture specialized for LLM decoding while remaining compatible with conventional prefill execution. Evaluations show that EVA achieves up to 11.17$\times$ speedup and 7.17$\times$ higher energy efficiency compared with the SOTA lookup-based architecture, while preserving arithmetic precision after vector quantization. Our code is available at https://github.com/dbw6/Eva.git.

cs.AR↗

arXiv2026

FMSD-TTS: Few-shot Multi-Speaker Multi-Dialect Text-to-Speech Synthesis for Ü-Tsang, Amdo and Kham Speech Dataset Generation

Tibetan is a low-resource language with minimal parallel speech corpora spanning its three major dialects-Ü-Tsang, Amdo, and Kham-limiting progress in speech modeling. To address this issue, we propose FMSD-TTS, a few-shot, multi-speaker, multi-dialect text-to-speech framework that synthesizes parallel dialectal speech from limited reference audio and explicit dialect labels. Our method features a novel speaker-dialect fusion module and a Dialect-Specialized Dynamic Routing Network (DSDR-Net) to capture fine-grained acoustic and linguistic variations across dialects while preserving speaker identity. Extensive objective and subjective evaluations demonstrate that FMSD-TTS significantly outperforms baselines in both dialectal expressiveness and speaker similarity. We further validate the quality and utility of the synthesized speech through a challenging speech-to-speech dialect conversion task. Our contributions include: (1) a novel few-shot TTS system tailored for Tibetan multi-dialect speech synthesis, (2) the public release of a large-scale synthetic Tibetan speech corpus generated by FMSD-TTS, and (3) an open-source evaluation toolkit for standardized assessment of speaker similarity, dialect consistency, and audio quality.

cs.SD↗

arXiv2026

TMD-TTS: A Unified Tibetan Multi-Dialect Text-to-Speech Framework for Ü-Tsang, Amdo and Kham Speech Dataset Generation

Tibetan is a low-resource language with limited parallel speech corpora spanning its three major dialects (Ü-Tsang, Amdo, and Kham), limiting progress in speech modeling. To address this issue, we propose TMD-TTS, a unified Tibetan multi-dialect text-to-speech (TTS) framework that synthesizes parallel dialectal speech from explicit dialect labels. Our method features a dialect fusion module and a Dialect-Specialized Dynamic Routing Network (DSDR-Net) to capture fine-grained acoustic and linguistic variations across dialects. Extensive objective and subjective evaluations demonstrate that TMD-TTS significantly outperforms baselines in dialectal expressiveness. We further validate the quality and utility of the synthesized speech through a challenging Speech-to-Speech Dialect Conversion (S2SDC) task.

cs.CL↗

arXiv2026

DeepInv: A Novel Self-supervised Learning Approach for Fast and Accurate Diffusion Inversion

Diffusion inversion is a task of recovering the noise of an image in a diffusion model, which is vital for controllable diffusion image editing. At present, diffusion inversion still remains a challenging task due to the lack of viable supervision signals. Thus, most existing methods resort to approximation-based solutions, which however are often at the cost of performance or efficiency. To remedy these shortcomings, we propose a novel self-supervised diffusion inversion approach in this paper, termed Deep Inversion (DeepInv). Instead of requiring ground-truth noise annotations, we introduce a self-supervised objective as well as a data augmentation strategy to generate high-quality pseudo noises from real images without manual intervention. Based on these two innovative designs, DeepInv is also equipped with an iterative and multi-scale training regime to train a parameterized inversion solver, thereby achieving the fast and accurate image-to-noise mapping. To the best of our knowledge, this is the first attempt of presenting a trainable solver to predict inversion noise step by step. The extensive experiments show that our DeepInv can achieve much better performance and inference speed than the compared methods, e.g., +40.435% SSIM than EasyInv and +9887.5% speed than ReNoise on COCO dataset. Moreover, our careful designs of trainable solvers can also provide insights to the community. Codes and model parameters will be released in https://github.com/potato-kitty/DeepInv.

cs.CV↗

arXiv2025

Focus: A Streaming Concentration Architecture for Efficient Vision-Language Models

Vision-Language Models (VLMs) have demonstrated strong performance on tasks such as video captioning and visual question answering. However, their growing scale and video-level inputs lead to significant computational and memory overhead, posing challenges for real-time deployment on hardware accelerators. While prior work attempts to reduce redundancy via token pruning or merging, these methods typically operate at coarse granularity and incur high runtime overhead due to global token-level operations. In this study, we propose Focus, a Streaming Concentration Architecture that efficiently accelerates VLM inference through progressive, fine-grained redundancy elimination. Focus introduces a multilevel concentration paradigm that hierarchically compresses vision-language inputs at three levels: (1) semantic-guided token pruning based on textual prompts, (2) spatial-temporal block-level concentration using localized comparisons, and (3) vector-level redundancy removal via motion-aware matching. All concentration steps are tightly co-designed with the architecture to support streaming-friendly, on-chip execution. Focus leverages GEMM tiling, convolution-style layout, and cross-modal attention to minimize off-chip access while enabling high throughput. Implemented as a modular unit within a systolic-array accelerator, Focus achieves a 2.4x speedup and 3.3x reduction in energy, significantly outperforming state-of-the-art accelerators in both performance and energy efficiency. Full-stack implementation of Focus is open-sourced at https://github.com/dubcyfor3/Focus.

cs.AR↗

arXiv2025

ObjectAdd: Adding Objects into Image via a Training-Free Diffusion Modification Fashion

We introduce ObjectAdd, a training-free diffusion modification method to add user-expected objects into user-specified area. The motive of ObjectAdd stems from: first, describing everything in one prompt can be difficult, and second, users often need to add objects into the generated image. To accommodate with real world, our ObjectAdd maintains accurate image consistency after adding objects with technical innovations in: (1) embedding-level concatenation to ensure correct text embedding coalesce; (2) object-driven layout control with latent and attention injection to ensure objects accessing user-specified area; (3) prompted image inpainting in an attention refocusing & object expansion fashion to ensure rest of the image stays the same. With a text-prompted image, our ObjectAdd allows users to specify a box and an object, and achieves: (1) adding object inside the box area; (2) exact content outside the box area; (3) flawless fusion between the two areas

cs.CV↗

arXiv2025

Listening, Imagining & Refining: A Heuristic Optimized ASR Correction Framework with LLMs

Automatic Speech Recognition (ASR) systems remain prone to errors that affect downstream applications. In this paper, we propose LIR-ASR, a heuristic optimized iterative correction framework using LLMs, inspired by human auditory perception. LIR-ASR applies a "Listening-Imagining-Refining" strategy, generating phonetic variants and refining them in context. A heuristic optimization with finite state machine (FSM) is introduced to prevent the correction process from being trapped in local optima and rule-based constraints help maintain semantic fidelity. Experiments on both English and Chinese ASR outputs show that LIR-ASR achieves average reductions in CER/WER of up to 1.5 percentage points compared to baselines, demonstrating substantial accuracy gains in transcription.

eess.AS↗

arXiv2025

EMind: A Foundation Model for Multi-task Electromagnetic Signals Understanding

Deep understanding of electromagnetic signals is fundamental to dynamic spectrum management, intelligent transportation, autonomous driving and unmanned vehicle perception. The field faces challenges because electromagnetic signals differ greatly from text and images, showing high heterogeneity, strong background noise and complex joint time frequency structure, which prevents existing general models from direct use. Electromagnetic communication and sensing tasks are diverse, current methods lack cross task generalization and transfer efficiency, and the scarcity of large high quality datasets blocks the creation of a truly general multitask learning framework. To overcome these issue, we introduce EMind, an electromagnetic signals foundation model that bridges large scale pretraining and the unique nature of this modality. We build the first unified and largest standardized electromagnetic signal dataset covering multiple signal types and tasks. By exploiting the physical properties of electromagnetic signals, we devise a length adaptive multi-signal packing method and a hardware-aware training strategy that enable efficient use and representation learning from heterogeneous multi-source signals. Experiments show that EMind achieves strong performance and broad generalization across many downstream tasks, moving decisively from task specific models to a unified framework for electromagnetic intelligence. The code is available at: https://github.com/GabrielleTse/EMind.

eess.SP↗

arXiv2025

EasyInv: Toward Fast and Better DDIM Inversion

This paper introduces EasyInv, an easy yet novel approach that significantly advances the field of DDIM Inversion by addressing the inherent inefficiencies and performance limitations of traditional iterative optimization methods. At the core of our EasyInv is a refined strategy for approximating inversion noise, which is pivotal for enhancing the accuracy and reliability of the inversion process. By prioritizing the initial latent state, which encapsulates rich information about the original images, EasyInv steers clear of the iterative refinement of noise items. Instead, we introduce a methodical aggregation of the latent state from the preceding time step with the current state, effectively increasing the influence of the initial latent state and mitigating the impact of noise. We illustrate that EasyInv is capable of delivering results that are either on par with or exceed those of the conventional DDIM Inversion approach, especially under conditions where the model's precision is limited or computational resources are scarce. Concurrently, our EasyInv offers an approximate threefold enhancement regarding inference efficiency over off-the-shelf iterative optimization techniques. It can be easily combined with most existing inversion methods by only four lines of code. See code at https://github.com/potato-kitty/EasyInv.

cs.CV↗

arXiv2025

TiSpell: A Semi-Masked Methodology for Tibetan Spelling Correction covering Multi-Level Error with Data Augmentation

Multi-level Tibetan spelling correction addresses errors at both the character and syllable levels within a unified model. Existing methods focus mainly on single-level correction and lack effective integration of both levels. Moreover, there are no open-source datasets or augmentation methods tailored for this task in Tibetan. To tackle this, we propose a data augmentation approach using unlabeled text to generate multi-level corruptions, and introduce TiSpell, a semi-masked model capable of correcting both character- and syllable-level errors. Although syllable-level correction is more challenging due to its reliance on global context, our semi-masked strategy simplifies this process. We synthesize nine types of corruptions on clean sentences to create a robust training set. Experiments on both simulated and real-world data demonstrate that TiSpell, trained on our dataset, outperforms baseline models and matches the performance of state-of-the-art approaches, confirming its effectiveness.

cs.CL↗

arXiv2025

SCOPE-DTI: Semi-Inductive Dataset Construction and Framework Optimization for Practical Usability Enhancement in Deep Learning-Based Drug Target Interaction Prediction

Deep learning-based drug-target interaction (DTI) prediction methods have demonstrated strong performance; however, real-world applicability remains constrained by limited data diversity and modeling complexity. To address these challenges, we propose SCOPE-DTI, a unified framework combining a large-scale, balanced semi-inductive human DTI dataset with advanced deep learning modeling. Constructed from 13 public repositories, the SCOPE dataset expands data volume by up to 100-fold compared to common benchmarks such as the Human dataset. The SCOPE model integrates three-dimensional protein and compound representations, graph neural networks, and bilinear attention mechanisms to effectively capture cross domain interaction patterns, significantly outperforming state-of-the-art methods across various DTI prediction tasks. Additionally, SCOPE-DTI provides a user-friendly interface and database. We further validate its effectiveness by experimentally identifying anticancer targets of Ginsenoside Rh1. By offering comprehensive data, advanced modeling, and accessible tools, SCOPE-DTI accelerates drug discovery research.

cs.LG↗

arXiv2025

LightMotion: A Light and Tuning-free Method for Simulating Camera Motion in Video Generation

Existing camera motion-controlled video generation methods face computational bottlenecks in fine-tuning and inference. This paper proposes LightMotion, a light and tuning-free method for simulating camera motion in video generation. Operating in the latent space, it eliminates additional fine-tuning, inpainting, and depth estimation, making it more streamlined than existing methods. The endeavors of this paper comprise: (i) The latent space permutation operation effectively simulates various camera motions like panning, zooming, and rotation. (ii) The latent space resampling strategy combines background-aware sampling and cross-frame alignment to accurately fill new perspectives while maintaining coherence across frames. (iii) Our in-depth analysis shows that the permutation and resampling cause an SNR shift in latent space, leading to poor-quality generation. To address this, we propose latent space correction, which reintroduces noise during denoising to mitigate SNR shift and enhance video generation quality. Exhaustive experiments show that our LightMotion outperforms existing methods, both quantitatively and qualitatively.

cs.CV↗

arXiv2025

Talking to the brain: Using Large Language Models as Proxies to Model Brain Semantic Representation

Traditional psychological experiments utilizing naturalistic stimuli face challenges in manual annotation and ecological validity. To address this, we introduce a novel paradigm leveraging multimodal large language models (LLMs) as proxies to extract rich semantic information from naturalistic images through a Visual Question Answering (VQA) strategy for analyzing human visual semantic representation. LLM-derived representations successfully predict established neural activity patterns measured by fMRI (e.g., faces, buildings), validating its feasibility and revealing hierarchical semantic organization across cortical regions. A brain semantic network constructed from LLM-derived representations identifies meaningful clusters reflecting functional and contextual associations. This innovative methodology offers a powerful solution for investigating brain semantic organization with naturalistic stimuli, overcoming limitations of traditional annotation methods and paving the way for more ecologically valid explorations of human cognition.

cs.AI↗

arXiv2024

FathomGPT: A Natural Language Interface for Interactively Exploring Ocean Science Data

We introduce FathomGPT, an open source system for the interactive investigation of ocean science data via a natural language interface. FathomGPT was developed in close collaboration with marine scientists to enable researchers to explore and analyze the FathomNet image database. FathomGPT provides a custom information retrieval pipeline that leverages OpenAI's large language models to enable: the creation of complex queries to retrieve images, taxonomic information, and scientific measurements; mapping common names and morphological features to scientific names; generating interactive charts on demand; and searching by image or specified patterns within an image. In designing FathomGPT, particular emphasis was placed on enhancing the user's experience by facilitating free-form exploration and optimizing response times. We present an architectural overview and implementation details of FathomGPT, along with a series of ablation studies that demonstrate the effectiveness of our approach to name resolution, fine tuning, and prompt modification. We also present usage scenarios of interactive data exploration sessions and document feedback from ocean scientists and machine learning experts.

cs.HC↗

arXiv2024

SpineCLUE: Automatic Vertebrae Identification Using Contrastive Learning and Uncertainty Estimation

Vertebrae identification in arbitrary fields-of-view plays a crucial role in diagnosing spine disease. Most spine CT contain only local regions, such as the neck, chest, and abdomen. Therefore, identification should not depend on specific vertebrae or a particular number of vertebrae being visible. Existing methods at the spine-level are unable to meet this challenge. In this paper, we propose a three-stage method to address the challenges in 3D CT vertebrae identification at vertebrae-level. By sequentially performing the tasks of vertebrae localization, segmentation, and identification, the anatomical prior information of the vertebrae is effectively utilized throughout the process. Specifically, we introduce a dual-factor density clustering algorithm to acquire localization information for individual vertebra, thereby facilitating subsequent segmentation and identification processes. In addition, to tackle the issue of interclass similarity and intra-class variability, we pre-train our identification network by using a supervised contrastive learning method. To further optimize the identification results, we estimated the uncertainty of the classification network and utilized the message fusion module to combine the uncertainty scores, while aggregating global information about the spine. Our method achieves state-of-the-art results on the VerSe19 and VerSe20 challenge benchmarks. Additionally, our approach demonstrates outstanding generalization performance on an collected dataset containing a wide range of abnormal cases.

cs.CV↗