arXiv subjects

Zongyuan Ge

Publications and source records attributed to Zongyuan Ge.

At least 19 recordsLinked to original sources

arXiv2026

Digital-Analog Quantum Neural Network with Long-Range Interactions

Protocols combining single-qubit digital operations with analog quantum evolutions bypass large numbers of two-qubit entangling gates, offering a promising approach to variational algorithms and hybrid quantum simulation. Focusing on the digital-analog quantum neural network (DA-QNN) as a representative framework, this work demonstrates that incorporating long-range interactions enhances the efficiency of such hybrid algorithms. Within the analog blocks, an Ising model with power-law interactions is employed to generate entanglement, and this protocol is benchmarked across supervised and unsupervised learning tasks. Beyond discussing the effects of the transverse field and evolution time, the primary analysis focuses on how the interaction range governs the expressibility and trainability of the ansatz. For supervised image classification and many-body phase detection, long-range ansatzes match the performance of their short-range counterparts with fewer DA-QNN layers or shorter evolution times, owing to the rapid information propagation across the system enabled by nonlocal couplings. This resource reduction alleviates the classical optimization overhead and eases experimental implementation. In unsupervised phase detection, although the long-range ansatz does not outperform its short-range counterpart in every regime, the two ansatzes provide complementary signatures that jointly reconstruct the complete phase diagram. These findings establish long-range interacting platforms as a compelling resource for advancing practical, large-scale digital-analog quantum computing.

quant-ph↗

arXiv2026

MedVTok: A General-Purpose Medical Visual Tokenizer

Multimodal medical AI requires a common visual interface for encoding heterogeneous imaging evidence for patient condition modeling. However, existing medical visual tokenizers are often tied to a specific dimension and imaging modality, forcing multimodal systems to rely on fragmented and poorly reusable representations. We introduce MedVTok, a general-purpose visual tokenizer that maps 2D images and 3D volumes from diverse imaging modalities into a unified token space. Building such a tokenizer poses two key challenges: preserving anatomical structure across dimensions and capturing clinical semantics across modalities. To this end, MedVTok introduces (i) slice differential regularization, which explicitly models inter-slice anatomical coherence missing in previous per-pixel/per-voxel supervision, and (ii) multi-expert representation alignment, which integrates knowledge from multiple medical expert encoders while retaining modality-specific complementary knowledge. Trained on 28M images and 70K volumes across 9 imaging modalities, MedVTok supports classification, retrieval, segmentation, synthesis, visual question answering, and medical report generation through a single tokenizer. Across 24 benchmarks, MedVTok achieves state-of-the-art performance, demonstrating a scalable token interface that unifies medical image dimension, modality, and task usage.

eess.IV↗

arXiv2026

ColonAdapter: Geometry Estimation Through Foundation Model Adaptation for Colonoscopy

Estimating 3D geometry from monocular colonoscopy images is challenging due to non-Lambertian surfaces, moving light sources, and large textureless regions. While recent 3D geometric foundation models eliminate the need for multi-stage pipelines, their performance deteriorates in clinical scenes. These models are primarily trained on natural scene datasets and struggle with specularity and homogeneous textures typical in colonoscopy, leading to inaccurate geometry estimation. In this paper, we present ColonAdapter, a self-supervised fine-tuning framework that adapts geometric foundation models for colonoscopy geometry estimation. Our method leverages pretrained geometric priors while tailoring them to clinical data. To improve performance in low-texture regions and ensure scale consistency, we introduce a Detail Restoration Module (DRM) and a geometry consistency loss. Furthermore, a confidence-weighted photometric loss enhances training stability in clinical environments. Experiments on both synthetic and real datasets demonstrate that our approach achieves state-of-the-art performance in camera pose estimation, monocular depth prediction, and dense 3D point map reconstruction, without requiring ground-truth intrinsic parameters.

eess.IV↗

arXiv2026

DrugHarness: An Evolvable Agent Harness for Computational Drug Discovery

Computational drug discovery requires agents to compose scientific operations and adapt to changing evidence and constraints. Here we introduce DrugHarness, an evolvable agent harness coupling composable scientific execution with conditional skill induction. Its environment integrates over 80 scientific operations, biomedical resources and task-specific code, preserving associations among candidates, results and artifacts. From execution trajectories and outcome feedback, DrugHarness induces action hypotheses with observable applicability conditions, recommended actions and supporting evidence. An independent review agent evaluates candidate skills derived from these hypotheses through source verification and, when needed, targeted execution trials. Admitted skills guide subsequent tasks and are revised through feedback. Evaluation on MolBench and SMDD-Bench demonstrates capabilities in molecular screening, optimization and constrained design. Without evolution, DrugHarness exceeds reported MolClaw-CC results by 10.8 percentage points in affinity-comparison accuracy and 55% in mean top-three active hits on MolBench. Retrospective evaluation on skill-development tasks shows that evolution increases Qwen's affinity-comparison accuracy from 62.2% to 81.1% and optimization success from 79.5% to 87.2%. In a prospective HPK1 study, DrugHarness achieves a more favorable median docking score than Biomni among system-specific candidates. A synthesized compound achieves a cellular IC50 of 14.19 nM, a 2.64-fold potency improvement over the best input reference, with activity competitive with two selected compounds designed by experienced medicinal chemists. These results support conditional skill evolution for scientific agents and demonstrate a workflow connecting computational drug design with experimental validation.

cs.AI↗

arXiv2026

Prediction bias in biological ageing markers

Biological ageing markers have attracted growing interest, with models estimating age from organ imaging or blood biomarkers. An estimated age above chronological age or the age-specific population expectation is assumed to reflect accelerated ageing and poorer health. Previous research has supported this assumption through positive associations between disease and age gaps or acceleration. However, in this study, we identified a widespread health-dependent prediction bias in ageing markers that affects their key interpretation and application. Specifically, we investigated five ageing markers derived from retinal images, brain MRI, chest radiographs, abdominal CT, and blood tests, and evaluated them using association analyses. We observed the well-recognised phenomenon of regression to the mean (RTM) in the four organ-image based markers, whereby estimated ages were shifted towards the mean age of the training cohort. More importantly, we revealed that the strength of RTM varied with health status, with stronger RTM in unhealthy than in healthy individuals. This differential RTM introduced a health-dependent prediction bias that persisted after calibration and systematically altered associations across age subgroups, suggesting that whole cohort associations may not reflect those observed within individual age subgroups. Additionally, we showed that the tested ageing markers, including PhenoAge derived from blood biomarkers, had limited ability to distinguish health status at the individual level. These findings call for careful interpretation of biological ageing markers and their use in clinical studies, and highlight the need for further development and validation before these ageing markers can reliably inform individual health assessments.

q-bio.QM↗

arXiv2026

A Multimodal Feature Distillation with Mamba-Transformer Network for Brain Tumor Segmentation with Incomplete Modalities

Existing brain tumor segmentation methods usually utilize multiple Magnetic Resonance Imaging (MRI) modalities in brain tumor images for segmentation, which can achieve better segmentation performance. However, in clinical applications, some modalities are often missing due to resource constraints, resulting in significant performance degradation for methods that rely on complete modality segmentation. In this paper, we propose a Multimodal feature distillation with Mamba-Transformer hybrid network (MMTSeg) for accurate brain tumor segmentation with missing modalities. We first employ a Multimodal Feature Distillation (MFD) module to distill feature-level multimodal knowledge into different unimodalities to extract complete modality information. We further develop an Unimodal Feature Enhancement (UFE) module to model the semantic relationship between global and local information. Finally, we built a Cross-Modal Fusion (CMF) module to explicitly align the global correlations across modalities, even when some modalities are missing. Complementary features within and across modalities are refined by the Mamba-Transformer hybrid architectures in both the UFE and CMF modules, dynamically capturing long-range dependencies and global semantic information for complex spatial contexts. A boundary-wise loss function is employed as the segmentation loss of the proposed MMTSeg to minimize boundary discrepancies for a distance-based metric. Our ablation study demonstrates the importance of the proposed feature enhancement and fusion modules in the proposed network and the Transformer with Mamba block for improving the performance of brain tumor segmentation with missing modalities. Extensive experiments on the BraTS 2018 and BraTS 2020 datasets demonstrate that the proposed MMTSeg framework outperforms state-of-the-art methods when modalities are missing.

cs.CV↗

arXiv2026

CFR-Net:Collaborative Feature Refinement Network for Medical Image Anomaly Detection

Medical image anomaly detection is central to timely diagnosis and clinical decision support, yet abnormal samples are costly to collect because of disease rarity, privacy concerns, and expert workload. This motivates unsupervised learning from normal images, where abnormalities are detected as deviations from learned normal patterns. However, medical anomalies are often subtle, local, and intertwined with normal anatomical variations, which complicates reliable normality modeling. Distillation-based methods support normality modeling by using frozen pretrained teachers as stable feature references, yet mismatches between generic teacher priors and student representations adapted to medical images can produce residuals unrelated to abnormalities in conventional distillation pipelines. To address this limitation, we propose the Collaborative Feature Refinement Network, which learns normality through a coupled process of shared feature conditioning before decoding and cross-space consistency after decoding. Shared feature conditioning performs medical-aware conditioning on teacher and student features under common rules, while cross-space consistency constrains each decoded stream with the complementary encoder representation for reciprocal normal reconstruction. The coupled process is further stabilized by the homework set reorganization strategy, which periodically refreshes normal training subsets. Experiments on six medical image benchmarks show competitive anomaly classification and strong anomaly localization performance.

cs.CV↗

arXiv2026

Aurora Hunter: A Two-Stage Framework for Probabilistic Visibility Forecasting

Aurora visibility at a given location requires two physically distinct conditions to hold at once: aurora occurring overhead, governed by solar wind-magnetosphere coupling, and observing conditions that permit detection, governed by cloud cover and moonlight. Approaches that conflate the two weaken the space-weather signal and limit cross-site generalizability. We develop Aurora Hunter, a two-stage cascade that separates occurrence prediction from observing-condition assessment. Stage 1 uses 43 physics-driven features to predict P(aurora identifiable in all-sky images) via gradient-boosted trees trained on joint Tromso+Kiruna data (about 16,600 hours, 2015-2023). Stage 2 models P(unobscured image class | identifiable) with logistic regression on 15 observing-condition features, trained on hours with identifiable aurora. The cascade P(visible) = P(identifiable) x P(unobscured | identifiable) achieves retrospective ROC-AUC of 0.958 (Tromso test, 2019-2020) and 0.933 (independent Kiruna, 2024), improving on the occurrence stage used alone by +0.095 and +0.097. Transfer to Skibotn, the one station withheld entirely (2022-2025), is limited. SHAP analysis identifies magnetic local time, the Kp x nightside interaction and the three-hour mean Kp as the dominant features (44% of attribution), consistent with auroral oval physics. Hemisphere-wide occurrence maps combine the Stage 1 amplitude, on a clear-sky basis, with the Feldstein oval parameterization. By providing location-specific visibility probabilities with measured reliability rather than coarse geomagnetic indices, the framework links space weather research to practical observation planning. An operational proof of concept is available at https://aurora-hunter.onrender.com

physics.space-ph↗

arXiv2026

Steering the Compass: Aligning Dynamic Psychological Counseling Conversations with Cognitive Behavioral Therapy Strategies

Recent advancements in large language models have revolutionized the field of psychological counseling, especially in the context of Cognitive Behavioral Therapy (CBT). While the success of CBT relies heavily on dynamic decision-making informed by the client's real-time mental state, this aspect has often been overlooked in current research, limiting both flexibility and therapeutic outcomes. In this paper, we introduce StratCBT, a dataset specifically designed for psychological counseling conversations with CBT Strategies, consisting of 9,688 sessions and around 256K utterances, with each counselor's response aligned with one of eight distinct strategies. The creation of StratCBT involves modeling clients based on their negative thoughts and generating high-quality counseling conversations through self-chat, incorporating realistic sessions as guidance, thereby significantly surpassing existing datasets in both general counseling and CBT-specific skills. We conduct extensive experiments to demonstrate the effectiveness of strategy-aligned generation and evaluate its efficacy in delivering professional and effective counseling with LLM-simulated clients to reflect real-world scenarios. The dataset can be obtained from https://github.com/zimuwangnlp/StratCBT.

cs.CL↗

arXiv2026

XPos3R: Cross-Modal Transformer for Intraoperative 2D/3D Registration

Intraoperative 2D/3D registration, which aligns live X-ray images with preoperative volumes, is essential for image-guided interventions. Previous regression-based methods suffer from limited generalization, thus requiring time-consuming patient-specific retraining. Inspired by recent geometry foundation models such as DUSt3R, we propose XPos3R, a generalizable pose regression method that eliminates preoperative preparation. Unlike existing geometry models designed for homogeneous inputs, XPos3R extends this paradigm to multi-modal inputs, namely 2D X-rays and 3D volumes. Specifically, we introduce an asymmetric encoder-decoder architecture that improves cross-modal feature alignment while maintaining computational efficiency. To scale training under limited medical data, we adopt an anatomy-specific data curation strategy and construct million-scale synthetic datasets. Evaluated on real-world benchmarks, a single pretrained XPos3R surpasses patient-specific methods in both accuracy and robustness. With test-time optimization completed in seconds, it further reduces the 3D error to <4 mm and the reprojection error to <1 mm. The strong generalization, accuracy, and efficiency of XPos3R highlight its clinical potential, while its asymmetric framework may inspire broader cross-modal vision geometry tasks.

eess.IV↗

arXiv2026

Do No Harm: Exposing Hidden Vulnerabilities of LLMs via Persona-based Client Simulation Attack in Psychological Counseling

The increasing use of large language models (LLMs) in mental healthcare raises safety concerns in high-stakes therapeutic interactions. A key challenge is distinguishing therapeutic empathy from maladaptive validation, where supportive responses may inadvertently reinforce harmful beliefs or behaviors in multi-turn conversations. This risk is largely overlooked by existing red-teaming frameworks, which focus mainly on generic harms or optimization-based attacks. To address this gap, we introduce Personality-based Client Simulation Attack (PCSA), the first red-teaming framework that simulates clients in psychological counseling through coherent, persona-driven client dialogues to expose vulnerabilities in psychological safety alignment. Experiments on seven general and mental health-specialized LLMs show that PCSA substantially outperforms four competitive baselines. Perplexity analysis and human inspection further indicate that PCSA generates more natural and realistic dialogues. Our results reveal that current LLMs remain vulnerable to domain-specific adversarial tactics, providing unauthorized medical advice, reinforcing delusions, and implicitly encouraging risky actions.

cs.CL↗

arXiv2026

VIBE-Bench: Evaluating Personalized Large Language Models When Profiles Don't Mean Preferences

Personalized Large Language Models (PLLMs) aim to tailor responses to individual users, where a central challenge is preference reasoning: inferring query-relevant preferences from user-related history. Existing benchmarks, however, largely assume that such preference can be retrieved from semantically related history. We study an underexplored but practically important regime, profile-preference conceptual misalignment (PRCM), where observable profile cues and query-specific preferences lie in different concept spaces, making semantic retrieval inconsistent for personalization. We introduce VIBE-Bench, a benchmark with two psychology-grounded tasks, 3,504 personas and 12,239 dialogues, including a manually verified gold test set, and requires cross-concept preference reasoning beyond surface semantic overlap. Experiments with several personalization methods show that current PLLMs largely rely on shallow semantic correlations and fail to acquire robust cross-concept mappings. These findings establish PRCM as a distinct failure regime in PLLMs and position VIBE-Bench as a focused testbed for advancing preference reasoning beyond semantic matching.

cs.AI↗

arXiv2026

SDARE-Bench: Evaluating Large Language Models on Conversational Stigma Detection and Response in Dyadic and Group Dialogue

Large Language Models (LLMs) are increasingly used in advice seeking and decision making that may affect social judgements. Despite stigma's profound effects on people and communities, benchmarks remain scarce. Existing general-domain evaluations typically rely on static prompts and fixed-format tasks, overlooking conversational contexts and audience effects in everyday communication. To address these gaps, we introduce SDARE-Bench, the first scenario-based benchmark evaluating both stigma detection and open-ended response generation in LLMs, comprising 1,138 dyadic queries and 1,388 group dialogue. Empirical results across 8 LLMs consistently demonstrate poor identification of stigma components, especially in group dialogues. In open-ended response generation, stigma expression was substantially higher in group settings than in dyadic, with weaker resistance to stigma and more unrealistic advice. Responses were evaluated using a classifier trained on 1,392 human annotated responses. In constructed group pressure settings, stigma expression rates further increased to a striking average of 97.5%. Our findings identify stigma response as a recurring LLM safety vulnerability, especially in socially complex conversational contexts.

cs.CL↗

arXiv2026

Learning Compositional Spatio-Temporal Video Grounding with Synthetic Curriculum

Despite the impressive progress of recent MLLMs on spatio-temporal video grounding (STVG), existing evaluations and training data focus primarily on simple queries. They largely overlook the compositional queries prevalent in real-world scenarios, where a target must be disambiguated by jointly reasoning about its attributes and relations to other entities. To bridge this gap, we propose Compositional Spatio-Temporal Video Grounding (CompSTVG), a task that requires models to process complex textual queries where every intertwined attribute and relational cue is essential for disambiguation. To facilitate this task at scale, we build a synthetic data engine that leverages a spatio-temporal scene graph as a difficulty measure and casts difficulty-controlled query synthesis as a constraint programming problem, producing difficulty-graded data for both evaluation and training. Built on this engine, we introduce STVG-CompBench, a benchmark stratified by explicit difficulty levels that jointly capture temporal complexity and spatial interference. Evaluating 11 representative STVG models on STVG-CompBench reveals that current models perform poorly on compositional queries, exhibiting a sharp performance drop that is typically obscured by overall dataset-level averages. We further construct synthetic training data and propose CurrSTVG, a curriculum reinforcement learning framework that delivers consistent gains, with the largest improvements observed on the most challenging compositional queries.

cs.CV↗

arXiv2026

Clinically Aligned Geometry Constraints for Robust IVUS Vessel Boundary Segmentation

Intravascular ultrasound (IVUS) lumen and external elastic membrane (EEM) segmentation is important for quantitative coronary plaque burden assessment. Errors in lumen or EEM delineation directly propagate to plaque area, plaque burden and geometric measurements. However, standard methods prioritising overlap scores often suffer from boundary drift and topology errors, leading to inaccurate clinical measurements. We present GeoCat, a geometry-consistent network that processes 5-frame IVUS clips using dual Cartesian-polar encoders with cross-domain attention and temporal fusion. A differentiable geometry consistency loss directly supervises clinically relevant descriptors including diameters, orientations, and cross-sectional areas. The model is trained on 12,242 annotated frames from 146 patients acquired with two commercial IVUS systems. We evaluate performance using both segmentation accuracy and plaque-relevant clinical metrics, including Dice/IoU, boundary measures(95HD (mm), ASSD), topology violation rate, and clinical geometry errors (dmax/dmin, angles, and areas). On our dataset, GeoCat achieves a Dice of 0.93, reduces 95HD to 0.14 mm, and lowers topology violations to 1.0%. Importantly, it significantly improves geometric fidelity, yielding diameter errors of 0.13-0.16 mm and angular errors of ~8 degrees, supporting reliable plaque burden quantification.

cs.CV↗

arXiv2026

Latent Ordinal Evidence, Misaligned Outputs: Inference-Time Ordinal Lens Alignment for Multimodal LLMs

Multimodal LLMs apply the language model interface to visual inputs, where ordinal regression tasks such as age estimation, image quality assessment, and disease grading require autoregressive decisions over ordered class labels. We ask whether MLLMs reliably convert internal ordinal evidence into ordered digit-token outputs. Across four ordinal benchmarks and four MLLM backbones, ordinal labels are linearly recoverable from hidden states with Spearman correlation up to 0.938, and a task-designed prompt further sharpens this structure. Yet native digit-token outputs weakly expose it: the unembedding matrix filters the ordinal direction, and the digit-token row space retains below 1.15% across all 16 model-dataset combinations, with a 16 to 77 absolute-point accuracy gap between linear-probe and native outputs. We introduce Ordinal Lens Alignment (OLA), a frozen-backbone inference-time method that trains lightweight W_S-anchored lenses on mid-to-deep decoder layers, fuses them into an ordinal distribution, and corrects only digit-token logits at generation. OLA outperforms the SOTA LoRA-tuned OrderChain baseline in most settings while keeping the MLLM frozen, surpasses discriminative ordinal baselines in most cells, and improves over an offline lens in every setting.

cs.CV↗

arXiv2026

Unlocking the Power of Medical Tabular Data via Semantic-Aware Multimodal Pre-training

While vision-language models dominate medical representation learning, unstructured text lacks the dense, quantitative diagnostic phenotypes inherent in structured clinical tables. However, existing multimodal pre-training methods underutilize this potential due to semantic-agnostic designs that treat tabular inputs as flat vectors and employ unstable continuous regression objectives. To overcome this, we propose a novel semantic-aware framework explicitly modeling the intrinsic two-dimensional structure of tabular data. First, addressing the inter-feature hierarchy of varying diagnostic importance, we introduce Importance-Aware Adaptive Masking to construct a label-free curriculum prioritizing salient features. Second, addressing the intra-feature continuity-discreteness duality, we propose a Soft-Label Discretized Module that replaces unstable numerical regression with stable distribution matching, thereby mathematically preserving ordinal relationships. Extensive experiments across large-scale dermatology (SLICE-3D, HOP) and ophthalmology (EyePACS) datasets establish a new state-of-the-art (SOTA), demonstrating exceptional robustness and cross-domain generalizability.

cs.CV↗

arXiv2026

ReMoE: Report-Guided Mixture-of-Experts for Multimodal OCT/OCTA Anomaly Detection

Multimodal medical anomaly detection identifies samples deviating from normal patterns, where scarce abnormal cases make normality modeling from normal data practical. In retinal Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) anomaly detection, existing unsupervised methods rely on visual feature distributions, reconstruction residuals, or encoder-decoder discrepancies, making anomaly scores depend on appearance-level deviations, while multimodal normality also contains semantic organization described in normal medical reports. To this end, we propose Report-Guided Mixture-of-Experts (ReMoE), which distills normal report semantics into an image-to-text prior student, builds modality-aware priors, and uses Report-Guided Modality Modulation (RMM) to modulate features through mixture-of-experts routing. Experiments on a private OCT/OCTA dataset with paired normal reports and a public OCTA500-3MM setting using a fixed normal report demonstrate state-of-the-art performance.

cs.CV↗