arXiv subjects

Zongyuan Ge

Publications and source records attributed to Zongyuan Ge.

At least 55 records · Page 3Linked to original sources

arXiv2026

Virtual Full-stack Scanning of Brain MRI via Imputing Any Quantised Code

Magnetic resonance imaging (MRI) is a powerful and versatile imaging technique, offering a wide spectrum of information about the anatomy by employing different acquisition modalities. However, in the clinical workflow, it is impractical to collect all relevant modalities due to the scan time and cost constraints. Virtual full-stack scanning aims to impute missing MRI modalities from available but incomplete acquisitions, offering a cost-efficient solution to enhance data completeness and clinical usability. Existing imputation methods often depend on global conditioning or modality-specific designs, which limit their generalisability across patient cohorts and imaging protocols. To address these limitations, we propose CodeBrain, a unified framework that reformulates various ``any-to-any'' imputation tasks as a region-level full-stack code prediction problem. CodeBrain adopts a two-stage pipeline: (1) it learns the compact representation of a complete MRI modality set by encoding it into scalar-quantised codes at the region level, enabling high-fidelity image reconstruction after decoding these codes along with modality-agnostic common features; (2) it trains a projection encoder to predict the full-stack code map from incomplete modalities via a grading-based design for diverse imputation scenarios. Extensive experiments on two public brain MRI datasets, i.e., IXI and BraTS 2023, demonstrate that CodeBrain consistently outperforms state-of-the-art methods, establishing a new benchmark for unified brain MRI imputation and enabling virtual full-stack scanning. Our code will be released at https://github.com/ycwu1997/CodeBrain.

cs.CV↗

arXiv2026

Towards Efficient Medical Reasoning with Minimal Fine-Tuning Data

Supervised Fine-Tuning (SFT) of the language backbone plays a pivotal role in adapting Vision-Language Models (VLMs) to specialized domains such as medical reasoning. However, existing SFT practices often rely on unfiltered textual datasets that contain redundant and low-quality samples, leading to substantial computational costs and suboptimal performance in complex clinical scenarios. Although existing methods attempt to alleviate this problem by selecting data based on sample difficulty, defined by knowledge and reasoning complexity, they overlook each sample's optimization utility reflected in its gradient. Interestingly, we find that gradient-based influence alone favors easy-to-optimize samples that cause large parameter shifts but lack deep reasoning chains, while difficulty alone selects noisy or overly complex textual cases that fail to guide stable optimization. Based on this observation, we propose a data selection strategy, Difficulty-Influence Quadrant (DIQ), which prioritizes samples in the "high-difficulty-high-influence" quadrant to balance complex clinical reasoning with substantial gradient influence. This enables efficient medical reasoning for VLMs with minimal fine-tuning data. Furthermore, Human and LLM-as-a-judge evaluations show that DIQ-selected subsets demonstrate higher data quality and generate clinical reasoning that is more aligned with expert practices in differential diagnosis, safety check, and evidence citation, as DIQ emphasizes samples that foster expert-like reasoning patterns. Extensive experiments on medical reasoning benchmarks demonstrate that DIQ enables VLM backbones fine-tuned on only 1% of selected data to match full-dataset performance, while using 10% consistently outperforms baseline methods, highlighting the superiority of principled data selection over brute-force scaling. The code is available at https://github.com/mihara-bot/DIQ.

cs.CL↗

arXiv2026

EyeAgent: An Agentic AI System for Multimodal Clinical Decision Support in Ophthalmology

Artificial intelligence has shown promise in medical imaging, yet most existing systems lack flexibility, interpretability, and adaptability - challenges especially pronounced in ophthalmology, where diverse imaging modalities are essential. We present EyeAgent, the first agentic AI framework for comprehensive and interpretable clinical decision support in ophthalmology. Using a large language model (DeepSeek-V3) as its central reasoning engine, EyeAgent interprets user queries and dynamically orchestrates 53 validated ophthalmic tools across 23 imaging modalities for diverse tasks including classification, segmentation, detection, image/report generation, and quantitative analysis. Stepwise ablation analysis demonstrated a progressive improvement in diagnostic accuracy, rising from a baseline of 69.71% (using only 5 general tools) to 80.79% when the full suite of 53 specialized tools was integrated. In an expert rating study on 200 real-world clinical cases, EyeAgent achieved 93.7% tool selection accuracy and received expert ratings of more than 88% across accuracy, completeness, safety, reasoning, and interpretability. In human-AI collaboration, EyeAgent matched or exceeded the performance of senior ophthalmologists and, when used as an assistant, improved overall diagnostic accuracy by 18.51% and report quality scores by 19%, with the greatest benefit observed among junior ophthalmologists. These findings establish EyeAgent as a scalable and trustworthy AI framework for ophthalmology and provide a blueprint for modular, multimodal, and clinically aligned next-generation AI systems.

cs.HC↗

arXiv2026

Thinking in Uncertainty: Mitigating Hallucinations in MLRMs with Latent Entropy-Aware Decoding

Recent advancements in multimodal large reasoning models (MLRMs) have significantly improved performance in visual question answering. However, we observe that transition words (e.g., because, however, and wait) are closely associated with hallucinations and tend to exhibit high-entropy states. We argue that adequate contextual reasoning information can be directly extracted from the token probability distribution. Inspired by superposed representation theory, we propose leveraging latent superposed reasoning to integrate multiple candidate semantics and maintain latent reasoning trajectories. The hypothesis is that reliance on discrete textual inputs may drive the model toward sequential explicit reasoning, underutilizing dense contextual cues during high-entropy reasoning stages. Therefore, we propose constructing rich semantic representations from the token probability distributions to enhance in-context reasoning. With this goal, we present Latent Entropy-Aware Decoding (LEAD), an efficient plug-and-play decoding strategy that leverages semantic context to achieve reliable reasoning. The heart of our method lies in entropy-aware reasoning mode switching. The model employs probability-weighted continuous embeddings under high-entropy states and transitions back to discrete token embeddings as entropy decreases. Moreover, we propose a prior-guided visual anchor injection strategy that encourages the model to focus on visual information. Extensive experiments show that LEAD effectively mitigates hallucinations across various MLRMs on multiple benchmarks.

cs.CV↗

arXiv2026

OPGAgent: An Agent for Auditable Dental Panoramic X-ray Interpretation

Orthopantomograms (OPGs) are the standard panoramic radiograph in dentistry, used for full-arch screening across multiple diagnostic tasks. While Vision Language Models (VLMs) now allow multi-task OPG analysis through natural language, they underperform task-specific models on most individual tasks. Agentic systems that orchestrate specialized tools offer a path to both versatility and accuracy, this approach remains unexplored in the field of dental imaging. To address this gap, we propose OPGAgent, a multi-tool agentic system for auditable OPG interpretation. OPGAgent coordinates specialized perception modules with a consensus mechanism through three components: (1) a Hierarchical Evidence Gathering module that decomposes OPG analysis into global, quadrant, and tooth-level phases with dynamically invoking tools, (2) a Specialized Toolbox encapsulating spatial, detection, utility, and expert zoos, and (3) a Consensus Subagent that resolves conflicts through anatomical constraints. We further propose OPG-Bench, a structured-report protocol based on (Location, Field, Value) triples derived from real clinical reports, which enables a comprehensive review of findings and hallucinations, extending beyond the limitations of VQA indicators. On our OPG-Bench and the public MMOral-OPG benchmark, OPGAgent outperforms current dental VLMs and medical agent frameworks across both structured-report and VQA evaluation. Code will be released upon acceptance.

cs.CV↗

arXiv2026

OneVision-Encoder: Codec-Aligned Sparsity as a Foundational Principle for Multimodal Intelligence

Hypothesis. Artificial general intelligence is, at its core, a compression problem. Effective compression demands resonance: deep learning scales best when its architecture aligns with the fundamental structure of the data. These are the fundamental principles. Yet, modern vision architectures have strayed from these truths: visual signals are highly redundant, while discriminative information, the surprise, is sparse. Current models process dense pixel grids uniformly, wasting vast compute on static background rather than focusing on the predictive residuals that define motion and meaning. We argue that to solve visual understanding, we must align our architectures with the information-theoretic principles of video, i.e., Codecs. Method. OneVision-Encoder encodes video by compressing predictive visual structure into semantic meaning. By adopting Codec Patchification, OV-Encoder abandons uniform computation to focus exclusively on the 3.1%-25% of regions rich in signal entropy. To unify spatial and temporal reasoning under irregular token layouts, OneVision-Encoder employs a shared 3D RoPE and is trained with a large-scale cluster discrimination objective over more than one million semantic concepts, jointly capturing object permanence and motion dynamics. Evidence. The results validate our core hypothesis: efficiency and accuracy are not a trade-off; they are positively correlated. When integrated into LLM, it consistently outperforms strong vision backbones such as Qwen3-ViT and SigLIP2 across 16 image, video, and document understanding benchmarks, despite using substantially fewer visual tokens and pretraining data. Notably, on video understanding tasks, OV-Encoder achieves an average improvement of 4.1% over Qwen3-ViT. Codec-aligned, patch-level sparsity is a foundational principle, enabling OV-Encoder as a scalable engine for next-generation visual generalists.

cs.CV↗

arXiv2026

PD-VLA: Accelerating Vision-Language-Action Model Integrated with Action Chunking via Parallel Decoding

Vision-Language-Action (VLA) models demonstrate remarkable potential for generalizable robotic manipulation. The performance of VLA models can be improved by integrating with action chunking, a critical technique for effective control. However, action chunking linearly scales up action dimensions in VLA models with increased chunking sizes. This reduces the inference efficiency. To tackle this problem, we propose PD-VLA, the first parallel decoding framework for VLA models integrated with action chunking. Our framework reformulates autoregressive decoding as a nonlinear system solved by parallel fixed-point iterations. This approach preserves model performance with mathematical guarantees while significantly improving decoding speed. In addition, it enables training-free acceleration without architectural changes, as well as seamless synergy with existing acceleration techniques. Extensive simulations validate that our PD-VLA maintains competitive success rates while achieving 2.52 times execution frequency on manipulators (with 7 degrees of freedom) compared with the fundamental VLA model. Furthermore, we experimentally identify the most effective settings for acceleration. Finally, real-world experiments validate its high applicability across different tasks.

cs.RO↗

arXiv2026

LATA: Laplacian-Assisted Transductive Adaptation for Conformal Uncertainty in Medical VLMs

Medical vision-language models (VLMs) are strong zero-shot recognizers for medical imaging, but their reliability under domain shift hinges on calibrated uncertainty with guarantees. Split conformal prediction (SCP) offers finite-sample coverage, yet prediction sets often become large (low efficiency) and class-wise coverage unbalanced-high class-conditioned coverage gap (CCV), especially in few-shot, imbalanced regimes; moreover, naively adapting to calibration labels breaks exchangeability and voids guarantees. We propose \texttt{\textbf{LATA}} (Laplacian-Assisted Transductive Adaptation), a \textit{training- and label-free} refinement that operates on the joint calibration and test pool by smoothing zero-shot probabilities over an image-image k-NN graph using a small number of CCCP mean-field updates, preserving SCP validity via a deterministic transform. We further introduce a \textit{failure-aware} conformal score that plugs into the vision-language uncertainty (ViLU) framework, providing instance-level difficulty and label plausibility to improve prediction set efficiency and class-wise balance at fixed coverage. \texttt{\textbf{LATA}} is black-box (no VLM updates), compute-light (windowed transduction, no backprop), and includes an optional prior knob that can run strictly label-free or, if desired, in a label-informed variant using calibration marginals once. Across \textbf{three} medical VLMs and \textbf{nine} downstream tasks, \texttt{\textbf{LATA}} consistently reduces set size and CCV while matching or tightening target coverage, outperforming prior transductive baselines and narrowing the gap to label-using methods, while using far less compute. Comprehensive ablations and qualitative analyses show that \texttt{\textbf{LATA}} sharpens zero-shot predictions without compromising exchangeability.

cs.CV↗

arXiv2026

Trustworthy and Fair SkinGPT-R1 for Democratizing Dermatological Reasoning across Diverse Ethnicities

The clinical translation of dermatological AI is hindered by opaque reasoning and systematic performance disparities across skin tones. Here we present SkinGPT-R1, a multimodal large language model that integrates chain-of-thought diagnostic reasoning with a fairness-aware mixture-of-experts architecture for interpretable and equitable skin disease diagnosis. Through parameter-efficient adaptation of a frozen reasoning backbone, SkinGPT-R1 generates structured diagnostic reports comprising visual findings, differential reasoning, and final diagnosis. Across seven external datasets spanning diverse pathologies and imaging conditions, SkinGPT-R1 achieves state-of-the-art accuracy on six benchmarks, including 82.50\% on a challenging 40-class long-tail classification task (+19.30\% over leading baselines). Blinded evaluation by five board-certified dermatologists on 1,000 phenotypically balanced cases yields a mean score of 3.6 out of 5, with the highest ratings in safety (3.8) and reasoning coherence (3.6), indicating that the generated rationales are clinically safe, logically grounded, and suitable for supporting diagnostic decision-making. Critically, SkinGPT-R1 mitigates algorithmic bias across the full Fitzpatrick spectrum, achieving a robust worst-group performance of 41.40\% on the Fitz17k benchmark and a five-fold relative improvement in lower-bound accuracy on the DDI dataset compared to standard multimodal baselines. These results establish a framework for trustworthy, fair, and explainable AI-assisted dermatological diagnosis.

cs.CV↗

arXiv2026

A Vision-Language Foundation Model for Zero-shot Clinical Collaboration and Automated Concept Discovery in Dermatology

Medical foundation models have shown promise in controlled benchmarks, yet widespread deployment remains hindered by reliance on task-specific fine-tuning. Here, we introduce DermFM-Zero, a dermatology vision-language foundation model trained via masked latent modelling and contrastive learning on over 4 million multimodal data points. We evaluated DermFM-Zero across 20 benchmarks spanning zero-shot diagnosis and multimodal retrieval, achieving state-of-the-art performance without task-specific adaptation. We further evaluated its zero-shot capabilities in three multinational reader studies involving over 1,100 clinicians. In primary care settings, AI assistance enabled general practitioners to nearly double their differential diagnostic accuracy across 98 skin conditions. In specialist settings, the model significantly outperformed board-certified dermatologists in multimodal skin cancer assessment. In collaborative workflows, AI assistance enabled non-experts to surpass unassisted experts while improving management appropriateness. Finally, we show that DermFM-Zero's latent representations are interpretable: sparse autoencoders unsupervisedly disentangle clinically meaningful concepts that outperform predefined-vocabulary approaches and enable targeted suppression of artifact-induced biases, enhancing robustness without retraining. These findings demonstrate that a foundation model can provide effective, safe, and transparent zero-shot clinical decision support.

cs.CV↗

arXiv2026

Cosmic Ray Inter-Station Correlation Variations as Precursors of Geomagnetic Storms: A Statistical Study and Multi-Parameter Early Warning Framework

The modulation of galactic cosmic rays (GCRs) by interplanetary disturbances, manifested as Forbush decreases (FDs), has long been recognized as a signature of coronal mass ejection (CME) passages through the heliosphere. While individual FD events have been extensively studied, systematic investigations of how GCR inter-station correlation variations relate to geomagnetic storm (GS) intensity have not been established. Here we analyze the relationship between GCR characteristics (from a global NM network) and GSs, aiming to understand the physical mechanisms of heliospheric disturbances and to develop complementary predictive capabilities beyond existing L1 solar wind monitoring. By applying a newly introduced anisotropy characteristic method alongside correlation analysis to 25 years of hourly NM data (1995-2020, seven stations), we demonstrate significant correlations between GCR parameters and geomagnetic activity. Inter-station relative differences and anisotropy enhancements show distinct precursor signatures depending on storm intensity, with extreme events displaying detectable signals 48-96 hours in advance. Based on these intensity-dependent response patterns, we propose a "two-stage multi-level" early warning framework: mid-term identification (48-96 hr) triggered by sustained anisotropy increases, followed by short-term grading (0-48 hr) based on inter-station relative difference variations and high-latitude flux changes. Validated on the extreme November 2003 and severe August 2018 geomagnetic storms, our approach successfully identifies precursor signals, providing a potential means to extend GS prediction windows.

astro-ph.SR↗

arXiv2026

A General Model for Retinal Segmentation and Quantification

Retinal imaging is fast, non-invasive, and widely available, offering quantifiable structural and vascular signals for ophthalmic and systemic health assessment. This accessibility creates an opportunity to study how quantitative retinal phenotypes relate to ocular and systemic diseases. However, such analyses remain difficult at scale due to the limited availability of public multi-label datasets and the lack of a unified segmentation-to-quantification pipeline. We present RetSAM, a general retinal segmentation and quantification framework for fundus imaging. It delivers robust multi-target segmentation and standardized biomarker extraction, supporting downstream ophthalmologic studies and oculomics correlation analyses. Trained on over 200,000 fundus images, RetSAM supports three task categories and segments five anatomical structures, four retinal phenotypic patterns, and more than 20 distinct lesion types. It converts these segmentation results into over 30 standardized biomarkers that capture structural morphology, vascular geometry, and degenerative changes. Trained with a multi-stage strategy using both private and public fundus data, RetSAM achieves superior segmentation performance on 17 public datasets. It improves on prior best methods by 3.9 percentage points in DSC on average, with up to 15 percentage points on challenging multi-task benchmarks, and generalizes well across diverse populations, imaging devices, and clinical settings. The resulting biomarkers enable systematic correlation analyses across major ophthalmic diseases, including diabetic retinopathy, age-related macular degeneration, glaucoma, and pathologic myopia. Together, RetSAM transforms fundus images into standardized, interpretable quantitative phenotypes, enabling large-scale ophthalmic research and translation.

cs.CV↗

arXiv2026

CHiRPE: A Step Towards Real-World Clinical NLP with Clinician-Oriented Model Explanations

The medical adoption of NLP tools requires interpretability by end users, yet traditional explainable AI (XAI) methods are misaligned with clinical reasoning and lack clinician input. We introduce CHiRPE (Clinical High-Risk Prediction with Explainability), an NLP pipeline that takes transcribed semi-structured clinical interviews to: (i) predict psychosis risk; and (ii) generate novel SHAP explanation formats co-developed with clinicians. Trained on 944 semi-structured interview transcripts across 24 international clinics of the AMP-SCZ study, the CHiRPE pipeline integrates symptom-domain mapping, LLM summarisation, and BERT classification. CHiRPE achieved over 90% accuracy across three BERT variants and outperformed baseline models. Explanation formats were evaluated by 28 clinical experts who indicated a strong preference for our novel concept-guided explanations, especially hybrid graph-and-text summary formats. CHiRPE demonstrates that clinically-guided model development produces both accurate and interpretable results. Our next step is focused on real-world testing across our 24 international sites.

cs.CL↗

arXiv2026

PanopMamba: Vision State Space Modeling for Nuclei Panoptic Segmentation

Nuclei panoptic segmentation supports cancer diagnostics by integrating both semantic and instance segmentation of different cell types to analyze overall tissue structure and individual nuclei in histopathology images. Major challenges include detecting small objects, handling ambiguous boundaries, and addressing class imbalance. To address these issues, we propose PanopMamba, a novel hybrid encoder-decoder architecture that integrates Mamba and Transformer with additional feature-enhanced fusion via state space modeling. We design a multiscale Mamba backbone and a State Space Model (SSM)-based fusion network to enable efficient long-range perception in pyramid features, thereby extending the pure encoder-decoder framework while facilitating information sharing across multiscale features of nuclei. The proposed SSM-based feature-enhanced fusion integrates pyramid feature networks and dynamic feature enhancement across different spatial scales, enhancing the feature representation of densely overlapping nuclei in both semantic and spatial dimensions. To the best of our knowledge, this is the first Mamba-based approach for panoptic segmentation. Additionally, we introduce alternative evaluation metrics, including image-level Panoptic Quality ($i$PQ), boundary-weighted PQ ($w$PQ), and frequency-weighted PQ ($fw$PQ), which are specifically designed to address the unique challenges of nuclei segmentation and thereby mitigate the potential bias inherent in vanilla PQ. Experimental evaluations on two multiclass nuclei segmentation benchmark datasets, MoNuSAC2020 and NuInsSeg, demonstrate the superiority of PanopMamba for nuclei panoptic segmentation over state-of-the-art methods. Consequently, the robustness of PanopMamba is validated across various metrics, while the distinctiveness of PQ variants is also demonstrated. Code is available at https://github.com/mkang315/PanopMamba.

eess.IV↗

arXiv2026

PsychEthicsBench: Evaluating Large Language Models Against Australian Mental Health Ethics

The increasing integration of large language models (LLMs) into mental health applications necessitates robust frameworks for evaluating professional safety alignment. Current evaluative approaches primarily rely on refusal-based safety signals, which offer limited insight into the nuanced behaviors required in clinical practice. In mental health, clinically inadequate refusals can be perceived as unempathetic and discourage help-seeking. To address this gap, we move beyond refusal-centric metrics and introduce \texttt{PsychEthicsBench}, the first principle-grounded benchmark based on Australian psychology and psychiatry guidelines, designed to evaluate LLMs' ethical knowledge and behavioral responses through multiple-choice and open-ended tasks with fine-grained ethicality annotations. Empirical results across 14 models reveal that refusal rates are poor indicators of ethical behavior, revealing a significant divergence between safety triggers and clinical appropriateness. Notably, we find that domain-specific fine-tuning can degrade ethical robustness, as several specialized models underperform their base backbones in ethical alignment. PsychEthicsBench provides a foundation for systematic, jurisdiction-aware evaluation of LLMs in mental health, encouraging more responsible development in this domain.

cs.CL↗

arXiv2026

DermoGPT: Open Weights and Open Data for Morphology-Grounded Dermatological Reasoning MLLMs

Multimodal Large Language Models (MLLMs) show promise for medical applications, yet progress in dermatology lags due to limited training data, narrow task coverage, and lack of clinically-grounded supervision that mirrors expert diagnostic workflows. We present a comprehensive framework to address these gaps. First, we introduce DermoInstruct, a large-scale morphology-anchored instruction corpus comprising 211,243 images and 772,675 trajectories across five task formats, capturing the complete diagnostic pipeline from morphological observation and clinical reasoning to final diagnosis. Second, we establish DermoBench, a rigorous benchmark evaluating 11 tasks across four clinical axes: Morphology, Diagnosis, Reasoning, and Fairness, including a challenging subset of 3,600 expert-verified open-ended instances and human performance baselines. Third, we develop DermoGPT, a dermatology reasoning MLLM trained via supervised fine-tuning followed by our Morphologically-Anchored Visual-Inference-Consistent (MAVIC) reinforcement learning objective, which enforces consistency between visual observations and diagnostic conclusions. At inference, we deploy Confidence-Consistency Test-time adaptation (CCT) for robust predictions. Experiments show DermoGPT significantly outperforms 16 representative baselines across all axes, achieving state-of-the-art performance while substantially narrowing the human-AI gap. DermoInstruct, DermoBench and DermoGPT will be made publicly available at https://github.com/mendicant04/DermoGPT upon acceptance.

cs.CL↗

arXiv2025

Cosmic-Ray-Constrained LSTM Model for Geomagnetic Storm Prediction

Geomagnetic storms (GSTs) driven by solar wind-magnetosphere coupling can severely disrupt technological systems, motivating the need for improved prediction accuracy and longer warning times. In this study, we develop a physics-informed Long Short-Term Memory (LSTM) model that incorporates cosmic-ray flux modulation as an additional precursor signal. As coronal mass ejection (CME)-driven disturbances propagate through the heliosphere, enhanced turbulence and magnetic-field compression reduce galactic cosmic-ray (GCR) flux measured by ground-based neutron monitors (Forbush decreases), providing early information that can precede near-Earth solar-wind signatures by 1--3 days. We integrate multi-source space-weather data, spanning 1995-2020, including cosmic-ray observations, solar wind plasma parameters, interplanetary magnetic-field data, and geomagnetic indices. Based on these data, we construct a 19-dimensional feature vector that includes flux background levels, decrease-related indicators, and inter-station correlation measures as model inputs. Employing a 50-unit LSTM architecture, the proposed model achieves root-mean-square errors (RMSE) of 5.106 nT, 8.315 nT, 10.854 nT, 12.883 nT, and 14.788 nT for 2-, 6-, 12-, 24-, and 48-hour predictions, respectively. Incorporating cosmic-ray information further improves 48-hour forecast skill by up to 25.84% (from 0.178 to 0.224). These results demonstrate the value of physics-informed deep learning and cosmic-ray precursors for advancing space-weather forecasting.

astro-ph.SR↗

arXiv2025

It Hears, It Sees too: Multi-Modal LLM for Depression Detection By Integrating Visual Understanding into Audio Language Models

Depression is one of the most prevalent mental health disorders globally. In recent years, multi-modal data, such as speech, video, and transcripts, has been increasingly used to develop AI-assisted depression assessment systems. Large language models have further advanced this field due to their strong language understanding and generalization capabilities. However, conventional LLMs remain text-centric and cannot process the rich non-verbal cues found in audio and visual modalities, which are critical components in mental health evaluation. While multi-modal LLMs offer a promising direction, few are tailored for psychological applications. In this study, we propose a novel multi-modal LLM framework for depression detection. Our approach augments an audio language model with visual understanding and aligns audio-visual features at the timestamp level. This fine-grained alignment improves modeling of temporal dynamics across modalities while reducing the need for extensive training data and computational resources. Experiments on the DAIC-WoZ dataset demonstrate that our model outperforms both single-modality approaches and previous multi-modal methods. Moreover, the proposed framework can be extended to incorporate additional physiological signals, paving the way for broader clinical applications beyond mental health.

cs.MM↗