Robust probabilistic measurement of structural-functional module consistency in infant brain development
Brain network is commonly divided into modules for analyzing their functionally segregated roles for group-level analysis in neuroimaging studies. Here, we introduce stochastic modules within brain networks for a robust probabilistic measurement of structural-functional module consistency (SFMC) in a group of subjects. Specifically, a stochastic module can be regarded as the chance of a brain region across subjects potentially being assigned to a group-level sub-network, characterized as an assignment probability for this brain region. This novel method has two advantages for evaluating inhomogeneous modules in brain networks. The first is that it can robustly evaluate the consistency between brain structural and functional modules whose population sizes are not necessary the same, and the second is that it is able to take into account the inter-individual variability of the modules for the groups. Moreover, compared with the conventional structural-functional coupling approach, our stochastic module-based method reveals a more pronounced decline in the coupling between structure and function, indicating stronger developmental reorganization. Our results using the dataset from Baby Connectome Project (BCP) show that the SFMC decreases from 0 to 5 years old, and is greater in primary brain regions, such as visual areas, while lower in more advanced cognitive regions, including those related to attention, control, and default mode network.