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arXiv2026

Evaluating the Effects of Inter-Observer and Model Variability on Radiological Peritoneal Cancer Index Assessment

Deep learning segmentation models are often evaluated using geometric metrics such as Dice, HD95, and ASD, yet it remains unclear to what extent improvements in these metrics translate into clinically meaningful changes in downstream decision-making. The metric-to-decision gap is examined using radiological Peritoneal Cancer Index (rPCI) region segmentation on contrast-enhanced CT, where a consensus definition provides anatomically grounded 3D regions and the clinically used PCI 20 threshold enables decision-level evaluation. Inter-observer variability is quantified across four experts on ten abdominal CT scans, and a published nnU-Net based rPCI segmentation model is benchmarked against this human reference using Dice, HD95, and ASD across all 13 regions. To relate geometric differences to clinical impact, a probabilistic peritoneal metastasis simulation is implemented on majority-vote rPCI maps, propagating region-boundary variability into variability of derived (r)PCI scores and classification at the PCI 20 cutoff. Observers showed high agreement (mean Dice $0.87$), while the model matched human performance in most regions but deviated more in regions 4, 8, and the small-bowel regions (9-12). Across simulations, score differences were typically small (mean $Δ$rPCI $\approx 0.3$-$0.6$) for both observers and the model, and decision flips occurred predominantly when the reference score was near 20. These results suggest that rPCI-derived scoring is generally robust to typical segmentation variability, while highlighting borderline cases as the main setting where expert review remains essential.

eess.IV↗

arXiv2026

Efficient JPEG Restoration in the Wavelet Domain via Mean Flows

Latest JPEG restoration systems achieve strong quality with large models, yet often remain too slow and expensive for efficient on-device deployment. We present a 65M-parameter generative restorer that attains the lowest LPIPS at QF 10 and 20 on LIVE-1, Urban100, and DIV2K-val while sustaining 8.05 images/s at $1024\times1024$ on a single RTX 3090, roughly $4.9\times$ the reported throughput of one-step SODiff at one-twentieth of its parameters. Trained from scratch, the model replaces the learned VAE encoder-decoder with an exactly invertible two-level Haar transform, predicts a clean wavelet-domain residual through a rank-enhanced linear-attention DiT that estimates compression severity internally, and is optimized with an improved MeanFlow objective that enables inference in one or two network evaluations without distillation. Large pretrained priors remain stronger under severe compression (QF 5), whereas our model prioritizes throughput for deployment-constrained restoration.

eess.IV↗

arXiv2026

Generative Translation Priors: Bayesian Imaging with Cross-Modality Image Translation

The ability to leverage images from co-available modalities to inform target-domain reconstruction is highly desirable in imaging algorithms. In this work, we introduce Generative Translation Priors (GTP)--a Bayesian framework that transforms diffusion-based image-to-image translation models into cross-modality image priors for ill-posed imaging inverse problems. GTP incorporates target-domain measurements through likelihood guidance, steering the translation process toward the desired posterior distribution. The framework is grounded in a theoretical analysis of the resulting posterior dynamics, which reveals an intrinsic bias introduced by likelihood guidance. We further characterize this bias and derive a ground-truth-free formulation for its estimation, enabling it to serve as a practical metric for assessing posterior sampling quality. Building on this analysis, we derive two discretized GTP algorithms based on gradient and proximal likelihood guidance, respectively. We validate GTP on computed tomography reconstruction with magnetic resonance side information, and on positron emission tomography reconstruction with computed tomography side information. Experiments demonstrate that GTP effectively incorporates complementary cross-modality information and achieves high-fidelity reconstruction even under severely undersampled measurements.

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arXiv2026

Destroy Me: Automatic Artifact Generation for Histopathology Images

Deep learning's diagnostic utility in pathology is constrained by model vulnerability to real-world data imperfections. While current strategies favor "perfect data" by filtering low-quality regions, which can lead to the loss of valuable diagnostic context, we propose a paradigm shift: engineering models to thrive in imperfect environments using "Destroy Me", a hybrid framework for realistic artifact synthesis and robust data augmentation. Our approach combines Stable Diffusion, fine-tuned to preserve morphological continuity by realistically integrating artifacts with the underlying tissue architecture, with physics-based procedural modeling to synthesize six common artifact types: tissue folds, precipitates, blur, stitching errors, dust, and pen markers. Artifact fidelity is assessed using Kernel Inception Distance (KID) and color Wasserstein distance metrics. Validating this strategy on lung adenocarcinoma pattern classification with an nnU-Net, we confirm that models trained on "destroyed" patches consistently outperform baselines on independent real-world datasets. Specifically, we observed a 10.5% relative improvement in macro F1-score and a 15% relative increase in the Cohen's Kappa ($κ$) coefficient. Crucially, our results demonstrate that selective, impact-weighted augmentation is vital for balancing practical robustness with the preservation of subtle diagnostic features.

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arXiv2026

CARDINAL Predicts Cardiovascular Risk From Non-contrast Cardiac CT

Cardiovascular risk prediction remains limited by incomplete clinical data and imaging biomarkers that reduce computed tomography (CT) to a small number of handcrafted features. We developed CARDINAL (Cardiovascular Assessment via Representation learning from Deep Imaging with Nested Anatomical Latent embeddings), a clinically grounded framework that learns compact representations from routine non-contrast cardiac CT for major adverse cardiovascular event (MACE) prediction. In 17,659 patients, CARDINAL was evaluated for 1-, 3-, 5-, and 10-year MACE prediction against American Heart Association (AHA) pooled cohort equations (PCE), AHA predicting risk of cardiovascular disease events (PREVENT), coronary artery calcium (CAC), segmentation-derived CT biomarkers, and 70-feature structural radiomics. Gains were largest at longer horizons. At 10 years, CARDINAL (joint) achieved an area under the receiver operating characteristic curve (AUROC) of 0.866 $\pm$ 0.020 and an area under the precision-recall curve (AUPRC) of 0.890 $\pm$ 0.015, compared with an AUROC of 0.826 $\pm$ 0.023 and an AUPRC of 0.826 $\pm$ 0.022 for structural radiomics, the strongest baseline. CARDINAL also achieved the highest survival concordance index (C-index), 0.753 $\pm$ 0.015, and high-versus-low risk-tertile hazard ratio, 10.78 $\pm$ 3.16, with favorable reclassification and exploratory calibration. These findings suggest that non-contrast cardiac CT contains prognostic information beyond conventional risk equations, CAC scoring, and engineered imaging biomarkers.

eess.IV↗

arXiv2026

Is Deformable Image Registration Ready for Brain Metastasis Reirradiation Dose Accumulation? A Longitudinal MRI Benchmark of Registration Accuracy

Dose accumulation is increasingly important in adaptive radiation therapy and reirradiation, but its clinical validity depends on the performance of deformable image registration (DIR). Reirradiation of brain metastases (BMs) with stereotactic radiosurgery (SRS) provides a controlled but clinically meaningful DIR test case: intra-subject brain deformation is usually limited after rigid alignment, yet recurrent lesions can undergo substantial local shape and volume changes that rigid registration cannot capture and can affect dose accumulation. We benchmarked a wide range of learning-based and optimization-based DIR methods on 87 manually screened longitudinal contrast-enhanced T1-weighted MRI lesion pairs from an institutional BM SRS retreatment cohort. Learning-based methods pretrained on healthy-brain MRI were evaluated zero-shot and after instance-specific optimization (ISO) or tumor-proximity target-specific optimization (TSO). Registration was assessed using lesion overlap (Dice), surface distance metrics (HD95 and sASD), target-volume recovery, and runtime and memory. Pretrained learning-based methods showed variable zero-shot performance, while ISO/TSO improved all tested learning-based families. However, optimization-based methods remained the best-performing approach while maintaining reasonable runtime. These findings suggest that even state-of-the-art DIR methods do not yet provide sufficiently accurate and consistent registration for unmonitored use in brain metastasis reirradiation dose accumulation. Because accurate registration is a prerequisite for deformable dose accumulation, clinical application will require case-level quality control and direct assessment of how registration uncertainty affects downstream dose metrics.

eess.IV↗

arXiv2026

Enhancing MRI Brain Tumor Edge Detection: A Hybrid Preprocessing Approach Utilizing CLAHE

Accurate boundary delineation of brain tumors in Magnetic Resonance Imaging (MRI) is a critical yet formidable challenge in neuro-oncology due to inherent scanner noise, complex anatomical structures, and uneven illumination. Traditional edge detection algorithms, while computationally lightweight and mathematically interpretable, frequently fail to capture the diffuse, localized boundaries of edema when relying solely on global preprocessing and manual parameter tuning. To overcome these limitations, we propose a hybrid automated edge detection pipeline. Our approach integrates an optimally configured Contrast-Limited Adaptive Histogram Equalization (CLAHE) layer into a comprehensive morphological preprocessing framework, followed by a deterministic sequential parameter sweep to fully automate threshold selection. The proposed hybrid model demonstrated enhancement in detecting critical anatomical structures in a publicly available benchmark database from Kaggle. By intelligently amplifying localized gradients without overwhelming the image with background noise, our method achieved higher Recall (Sensitivity). Consequently, the overall F1-Score elevated, and the Structural Similarity Index (SSIM) improved, all while maintaining a highly efficient execution. This establishes our optimized pipeline as a highly practical and near real-time operational model for clinical diagnostics, offering a compelling alternative to computationally heavy deep learning approaches.

eess.IV↗

arXiv2026

crossMoDA Challenge: Evolution of Cross-Modality Domain Adaptation Techniques for Vestibular Schwannoma and Cochlea Segmentation from 2021 to 2023

The cross-Modality Domain Adaptation (crossMoDA) challenge series, initiated in 2021 in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), focuses on unsupervised cross-modality segmentation, learning from contrast-enhanced T1 (ceT1) and transferring to T2 MRI. The task is an extreme example of domain shift chosen to serve as a meaningful and illustrative benchmark. From a clinical application perspective, it aims to automate Vestibular Schwannoma (VS) and cochlea segmentation on T2 scans for more cost-effective VS management. Over time, the challenge objectives have evolved to enhance its clinical relevance. The challenge evolved from using single-institutional data and basic segmentation in 2021 to incorporating multi-institutional data and Koos grading in 2022, and by 2023, it included heterogeneous routine data and sub-segmentation of intra- and extra-meatal tumour components. In this work, we report the findings of the 2022 and 2023 editions and perform a retrospective analysis of the challenge progression over the years. The observations from the successive challenge contributions indicate that the number of outliers decreases with an expanding dataset. This is notable since the diversity of scanning protocols of the datasets concurrently increased. The winning approach of the 2023 edition reduced the number of outliers on the 2021 and 2022 testing data, demonstrating how increased data heterogeneity can enhance segmentation performance even on homogeneous data. However, the cochlea Dice score declined in 2023, likely due to the added complexity from tumour sub-annotations affecting overall segmentation performance. While progress is still needed for clinically acceptable VS segmentation, the plateauing performance suggests that a more challenging cross-modal task may better serve future benchmarking.

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arXiv2026

Improved monocular depth prediction using distance transform over pre-semantic contours with self-supervised neural networks

Monocular depth estimation (MDE) with self-supervised training approaches struggles in low-texture areas, where photometric losses may lead to ambiguous depth predictions. To address this, we propose a novel technique that enhances spatial information by applying a distance transform over pre-semantic contours, augmenting discriminative power in low texture regions. Our approach jointly estimates pre-semantic contours, depth and ego-motion. The pre-semantic contours are leveraged to produce new input images, with variance augmented by the distance transform in uniform areas. This approach results in more effective loss functions, enhancing the training process for depth and ego-motion. We demonstrate theoretically that the distance transform is the optimal variance-augmenting technique in this context. Through extensive experiments on KITTI, Cityscapes, Waymo, NYUv2 and ScanNet our model demonstrates robust performance, surpassing competing self-supervised methods in MDE.

cs.CV↗

arXiv2026

GSNR: Graph Smooth Null-Space Representation for Inverse Problems

Inverse problems in imaging are ill-posed, leading to infinitely many solutions consistent with the measurements due to the non-trivial null-space of the sensing matrix. Common image priors promote solutions on the general image manifold, such as sparsity, smoothness, or score function. However, as these priors do not constrain the null-space component, they can bias the reconstruction. Thus, we aim to incorporate meaningful null-space information in the reconstruction framework. Inspired by smooth image representation on graphs, we propose Graph-Smooth Null-Space Representation (GSNR), a mechanism that imposes structure only into the invisible component. Particularly, given a graph Laplacian, we construct a null-restricted Laplacian that encodes similarity between neighboring pixels in the null-space signal, and we design a low-dimensional projection matrix from the $p$-smoothest spectral graph modes (lowest graph frequencies). This approach has strong theoretical and practical implications: i) improved convergence via a null-only graph regularizer, ii) better coverage, how much null-space variance is captured by $p$ modes, and iii) high predictability, how well these modes can be inferred from the measurements. GSNR is incorporated into well-known inverse problem solvers, e.g., PnP, DIP, and diffusion solvers, in four scenarios: image deblurring, compressed sensing, demosaicing, and image super-resolution, providing consistent improvement of up to 4.3 dB over baseline formulations and up to 1 dB compared with end-to-end learned models in terms of PSNR.

cs.CV↗

arXiv2026

Line-based Event Preprocessing: Towards Low-Energy Neuromorphic Computer Vision

Neuromorphic vision made significant progress in recent years, thanks to the natural match between spiking neural networks and event data in terms of biological inspiration, energy savings, latency and memory use for dynamic visual data processing. However, optimising its energy requirements still remains a challenge within the community, especially for embedded applications. One solution may reside in preprocessing events to optimise data quantity thus lowering the energy cost on neuromorphic hardware, proportional to the number of synaptic operations. To this end, we extend an end-to-end neuromorphic line detection mechanism to introduce line-based event data preprocessing. Our results demonstrate on three benchmark event-based datasets that preprocessing leads to an advantageous trade-off between energy consumption and classification performance. Depending on the line-based preprocessing strategy and the complexity of the classification task, we show that one can maintain or increase the classification accuracy while significantly reducing the theoretical energy consumption. Our approach systematically leads to a significant improvement of the neuromorphic classification efficiency, thus laying the groundwork towards a more frugal neuromorphic computer vision thanks to event preprocessing.

cs.NE↗

arXiv2025

Scalable FPGA Framework for Real-Time Denoising in High-Throughput Imaging: A DRAM-Optimized Pipeline using High-Level Synthesis

High-throughput imaging workflows, such as Parallel Rapid Imaging with Spectroscopic Mapping (PRISM), generate data at rates that exceed conventional real-time processing capabilities. We present a scalable FPGA-based preprocessing pipeline for real-time denoising, implemented via High-Level Synthesis (HLS) and optimized for DRAM-backed buffering. Our architecture performs frame subtraction and averaging directly on streamed image data, minimizing latency through burst-mode AXI4 interfaces. The resulting kernel operates below the inter-frame interval, enabling inline denoising and reducing dataset size for downstream CPU/GPU analysis. Validated under PRISM-scale acquisition, this modular FPGA framework offers a practical solution for latency-sensitive imaging workflows in spectroscopy and microscopy.

cs.AR↗

arXiv2025

Intelligent Software System for Low-Cost, Brightfield Segmentation: Algorithmic Implementation for Cytometric Auto-Analysis

Bright-field microscopy, a cost-effective solution for live-cell culture, is often the only resource available, along with standard CPUs, for many low-budget labs. The inherent challenges of bright-field images -- their noisiness, low contrast, and dynamic morphology -- coupled with a lack of GPU resources and complex software interfaces, hinder the desired research output. This article presents a novel microscopy image analysis framework designed for low-budget labs equipped with a standard CPU desktop. The Python-based program enables cytometric analysis of live, unstained cells in culture through an advanced computer vision and machine learning pipeline. Crucially, the framework operates on label-free data, requiring no manually annotated training data or training phase. It is accessible via a user-friendly, cross-platform GUI that requires no programming skills, while also providing a scripting interface for programmatic control and integration by developers. The end-to-end workflow performs semantic and instance segmentation, feature extraction, analysis, evaluation, and automated report generation. Its modular architecture supports easy maintenance and flexible integration while supporting both single-image and batch processing. Validated on several unstained cell types from the public dataset of livecells, the framework demonstrates superior accuracy and reproducibility compared to contemporary tools like Cellpose and StarDist. Its competitive segmentation speed on a CPU-based platform highlights its significant potential for basic research and clinical applications -- particularly in cell transplantation for personalised medicine and muscle regeneration therapies. The access to the application is available for reproducibility

q-bio.QM↗

arXiv2025

High-Throughput Low-Cost Segmentation of Brightfield Microscopy Live Cell Images

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for microscopic images, none consistently address the challenges of bright-field live-cell imaging with high throughput, where temporal phenotype changes, low contrast, noise, and motion-induced blur from cellular movement remain major obstacles. We developed a low-cost CNN-based pipeline incorporating comparative analysis of frozen encoders within a unified U-Net architecture enhanced with attention mechanisms, instance-aware systems, adaptive loss functions, hard instance retraining, dynamic learning rates, progressive mechanisms to mitigate overfitting, and an ensemble technique. The model was validated on a public dataset featuring diverse live cell variants, showing consistent competitiveness with state-of-the-art methods, achieving 93% test accuracy and an average F1-score of 89% (std. 0.07) on low-contrast, noisy, and blurry images. Notably, the model was trained primarily on bright-field images with limited exposure to phase- contrast microscopy (<20%), yet it generalized effectively to the phase-contrast LIVECell dataset, demonstrating modality, robustness and strong performance. This highlights its potential for real- world laboratory deployment across imaging conditions. The model requires minimal compute power and is adaptable using basic deep learning setups such as Google Colab, making it practical for training on other cell variants. Our pipeline outperforms existing methods in robustness and precision for bright-field microscopy segmentation. The code and dataset are available for reproducibility 1.

q-bio.QM↗

arXiv2025

Leveraging Unlabeled Audio-Visual Data in Speech Emotion Recognition using Knowledge Distillation

Voice interfaces integral to the human-computer interaction systems can benefit from speech emotion recognition (SER) to customize responses based on user emotions. Since humans convey emotions through multi-modal audio-visual cues, developing SER systems using both the modalities is beneficial. However, collecting a vast amount of labeled data for their development is expensive. This paper proposes a knowledge distillation framework called LightweightSER (LiSER) that leverages unlabeled audio-visual data for SER, using large teacher models built on advanced speech and face representation models. LiSER transfers knowledge regarding speech emotions and facial expressions from the teacher models to lightweight student models. Experiments conducted on two benchmark datasets, RAVDESS and CREMA-D, demonstrate that LiSER can reduce the dependence on extensive labeled datasets for SER tasks.

cs.LG↗

arXiv2025

L2RDaS: Synthesizing 4D Radar Tensors for Model Generalization via Dataset Expansion

4-dimensional (4D) radar is increasingly adopted in autonomous driving for perception tasks, owing to its robustness under adverse weather conditions. To better utilize the spatial information inherent in 4D radar data, recent deep learning methods have transitioned from using sparse point cloud to 4D radar tensors. However, the scarcity of publicly available 4D radar tensor datasets limits model generalization across diverse driving scenarios. Previous methods addressed this by synthesizing radar data, but the outputs did not fully exploit the spatial information characteristic of 4D radar. To overcome these limitations, we propose LiDAR-to-4D radar data synthesis (L2RDaS), a framework that synthesizes spatially informative 4D radar tensors from LiDAR data available in existing autonomous driving datasets. L2RDaS integrates a modified U-Net architecture to effectively capture spatial information and an object information supplement (OBIS) module to enhance reflection fidelity. This framework enables the synthesis of radar tensors across diverse driving scenarios without additional sensor deployment or data collection. L2RDaS improves model generalization by expanding real datasets with synthetic radar tensors, achieving an average increase of 4.25\% in ${{AP}_{BEV}}$ and 2.87\% in ${{AP}_{3D}}$ across three detection models. Additionally, L2RDaS supports ground-truth augmentation (GT-Aug) by embedding annotated objects into LiDAR data and synthesizing them into radar tensors, resulting in further average increases of 3.75\% in ${{AP}_{BEV}}$ and 4.03\% in ${{AP}_{3D}}$. The implementation will be available at https://github.com/kaist-avelab/K-Radar.

cs.CV↗

arXiv2025

Intelligent Road Anomaly Detection with Real-time Notification System for Enhanced Road Safety

This study aims to improve transportation safety, especially traffic safety. Road damage anomalies such as potholes and cracks have emerged as a significant and recurring cause for accidents. To tackle this problem and improve road safety, a comprehensive system has been developed to detect potholes, cracks (e.g. alligator, transverse, longitudinal), classify their sizes, and transmit this data to the cloud for appropriate action by authorities. The system also broadcasts warning signals to nearby vehicles warning them if a severe anomaly is detected on the road. Moreover, the system can count road anomalies in real-time. It is emulated through the utilization of Raspberry Pi, a camera module, deep learning model, laptop, and cloud service. Deploying this innovative solution aims to proactively enhance road safety by notifying relevant authorities and drivers about the presence of potholes and cracks to take actions, thereby mitigating potential accidents arising from this prevalent road hazard leading to safer road conditions for the whole community.

cs.CV↗

arXiv2025

Comparative Analysis of Unsupervised and Supervised Autoencoders for Nuclei Classification in Clear Cell Renal Cell Carcinoma Images

This study explores the application of supervised and unsupervised autoencoders (AEs) to automate nuclei classification in clear cell renal cell carcinoma (ccRCC) images, a diagnostic task traditionally reliant on subjective visual grading by pathologists. We evaluate various AE architectures, including standard AEs, contractive AEs (CAEs), and discriminative AEs (DAEs), as well as a classifier-based discriminative AE (CDAE), optimized using the hyperparameter tuning tool Optuna. Bhattacharyya distance is selected from several metrics to assess class separability in the latent space, revealing challenges in distinguishing adjacent grades using unsupervised models. CDAE, integrating a supervised classifier branch, demonstrated superior performance in both latent space separation and classification accuracy. Given that CDAE-CNN achieved notable improvements in classification metrics, affirming the value of supervised learning for class-specific feature extraction, F1 score was incorporated into the tuning process to optimize classification performance. Results show significant improvements in identifying aggressive ccRCC grades by leveraging the classification capability of AE through latent clustering followed by fine-grained classification. Our model outperforms the current state of the art, CHR-Network, across all evaluated metrics. These findings suggest that integrating a classifier branch in AEs, combined with neural architecture search and contrastive learning, enhances grading automation in ccRCC pathology, particularly in detecting aggressive tumor grades, and may improve diagnostic accuracy.

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