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PMFSNet: Polarized Multi-scale Feature Self-attention Network For Lightweight Medical Image Segmentation

Current state-of-the-art medical image segmentation methods prioritize accuracy but often at the expense of increased computational demands and larger model sizes. Applying these large-scale models to the relatively limited scale of medical image datasets tends to induce redundant computation, complicating the process without the necessary benefits. This approach not only adds complexity but also presents challenges for the integration and deployment of lightweight models on edge devices. For instance, recent transformer-based models have excelled in 2D and 3D medical image segmentation due to their extensive receptive fields and high parameter count. However, their effectiveness comes with a risk of overfitting when applied to small datasets and often neglects the vital inductive biases of Convolutional Neural Networks (CNNs), essential for local feature representation. In this work, we propose PMFSNet, a novel medical imaging segmentation model that effectively balances global and local feature processing while avoiding the computational redundancy typical in larger models. PMFSNet streamlines the UNet-based hierarchical structure and simplifies the self-attention mechanism's computational complexity, making it suitable for lightweight applications. It incorporates a plug-and-play PMFS block, a multi-scale feature enhancement module based on attention mechanisms, to capture long-term dependencies. Extensive comprehensive results demonstrate that even with a model (less than 1 million parameters), our method achieves superior performance in various segmentation tasks across different data scales. It achieves (IoU) metrics of 84.68%, 82.02%, and 78.82% on public datasets of teeth CT (CBCT), ovarian tumors ultrasound(MMOTU), and skin lesions dermoscopy images (ISIC 2018), respectively. The source code is available at https://github.com/yykzjh/PMFSNet.

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Conditional diffusion model with spatial attention and latent embedding for medical image segmentation

Diffusion models have been used extensively for high quality image and video generation tasks. In this paper, we propose a novel conditional diffusion model with spatial attention and latent embedding (cDAL) for medical image segmentation. In cDAL, a convolutional neural network (CNN) based discriminator is used at every time-step of the diffusion process to distinguish between the generated labels and the real ones. A spatial attention map is computed based on the features learned by the discriminator to help cDAL generate more accurate segmentation of discriminative regions in an input image. Additionally, we incorporated a random latent embedding into each layer of our model to significantly reduce the number of training and sampling time-steps, thereby making it much faster than other diffusion models for image segmentation. We applied cDAL on 3 publicly available medical image segmentation datasets (MoNuSeg, Chest X-ray and Hippocampus) and observed significant qualitative and quantitative improvements with higher Dice scores and mIoU over the state-of-the-art algorithms. The source code is publicly available at https://github.com/Hejrati/cDAL/.

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Striving for Simplicity: Simple Yet Effective Prior-Aware Pseudo-Labeling for Semi-Supervised Ultrasound Image Segmentation

Medical ultrasound imaging is ubiquitous, but manual analysis struggles to keep pace. Automated segmentation can help but requires large labeled datasets, which are scarce. Semi-supervised learning leveraging both unlabeled and limited labeled data is a promising approach. State-of-the-art methods use consistency regularization or pseudo-labeling but grow increasingly complex. Without sufficient labels, these models often latch onto artifacts or allow anatomically implausible segmentations. In this paper, we present a simple yet effective pseudo-labeling method with an adversarially learned shape prior to regularize segmentations. Specifically, we devise an encoder-twin-decoder network where the shape prior acts as an implicit shape model, penalizing anatomically implausible but not ground-truth-deviating predictions. Without bells and whistles, our simple approach achieves state-of-the-art performance on two benchmarks under different partition protocols. We provide a strong baseline for future semi-supervised medical image segmentation. Code is available at https://github.com/WUTCM-Lab/Shape-Prior-Semi-Seg.

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A Comprehensive Survey of Medical Image Segmentation: Challenges, Benchmarks, and Beyond

Medical image segmentation plays a critical role in clinical diagnostics, treatment planning, disease monitoring, and neurological disorder identification. This article presents a comprehensive review of its systematic development, covering widely used public datasets, representative methods built on the U-Net, Transformer, and SAM architectures, and key evaluation metrics with their differences, followed by an analysis of major challenges from multiple perspectives. Unlike surveys that focus on a single model family or a specific clinical application, this review organizes U-Net-, Transformer-, and SAM-based methods within a unified analytical framework, with a particular focus on their effectiveness in improving segmentation accuracy and efficiency. This work aims to guide future research and support clinical translation of medical image segmentation, with all related resources publicly available in our GitHub repository: https://github.com/andrew-pengyu/Awsome_MedSeg/tree/main.

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Weakly- and Semi-Supervised Learning of a DCNN for Semantic Image Segmentation

Deep convolutional neural networks (DCNNs) trained on a large number of images with strong pixel-level annotations have recently significantly pushed the state-of-art in semantic image segmentation. We study the more challenging problem of learning DCNNs for semantic image segmentation from either (1) weakly annotated training data such as bounding boxes or image-level labels or (2) a combination of few strongly labeled and many weakly labeled images, sourced from one or multiple datasets. We develop Expectation-Maximization (EM) methods for semantic image segmentation model training under these weakly supervised and semi-supervised settings. Extensive experimental evaluation shows that the proposed techniques can learn models delivering competitive results on the challenging PASCAL VOC 2012 image segmentation benchmark, while requiring significantly less annotation effort. We share source code implementing the proposed system at https://bitbucket.org/deeplab/deeplab-public.

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Diffusion-Based Quality Control of Medical Image Segmentations across Organs

Medical image segmentation using deep learning (DL) has enabled the development of automated analysis pipelines for large-scale population studies. However, state-of-the-art DL methods are prone to hallucinations, which can result in anatomically implausible segmentations. With manual correction impractical at scale, automated quality control (QC) techniques have to address the challenge. While promising, existing QC methods are organ-specific, limiting their generalizability and usability beyond their original intended task. To overcome this limitation, we propose no-new Quality Control (nnQC), a robust QC framework based on a diffusion-generative paradigm that self-adapts to any input organ dataset. Central to nnQC is a novel Team of Experts (ToE) architecture, where two specialized experts independently encode 3D spatial awareness, represented by the relative spatial position of an axial slice, and anatomical information derived from visual features from the original image. A weighted conditional module dynamically combines the pair of independent embeddings, or opinions to condition the sampling mechanism within a diffusion process, enabling the generation of a spatially aware pseudo-ground truth for predicting QC scores. Within its framework, nnQC integrates fingerprint adaptation to ensure adaptability across organs, datasets, and imaging modalities. We evaluated nnQC on seven organs using twelve publicly available datasets. Our results demonstrate that nnQC consistently outperforms state-of-the-art methods across all experiments, including cases where segmentation masks are highly degraded or completely missing, confirming its versatility and effectiveness across different organs.

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Image-Conditioned Instance Prompt Network for Referring Remote Sensing Image Segmentation

Referring Remote Sensing Image Segmentation (RRSIS) is a situated, task-driven cross-modal task related to the embodied perception paradigm, requiring models to align visual-spatial features with linguistic intentions for precise target perception. Recent research has focused on refining the granularity of textual features and optimizing image-text feature fusion to better guide target feature representations. However, insufficient descriptive granularity and sensitivity to semantic shifts can cause bottlenecks in cross-modal feature fusion. To address these issues, we propose the Image-Conditioned Instance Prompt Network (ICIPNet) with Bilateral Information Fusion, which is designed to alleviate bottlenecks in cross-modal feature fusion. ICIPNet introduces an Image-Conditioned Instance Prompt (ICIP) module to generate self-adaptive visual and semantic representations without external knowledge. The Bilateral Information Fusion (BIF) module enhances feature fusion along the token and channel dimensions. Experiments demonstrate that the proposed ICIPNet outperforms existing RRSIS models.

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DenseMP: Unsupervised Dense Pre-training for Few-shot Medical Image Segmentation

Few-shot medical image semantic segmentation is of paramount importance in the domain of medical image analysis. However, existing methodologies grapple with the challenge of data scarcity during the training phase, leading to over-fitting. To mitigate this issue, we introduce a novel Unsupervised Dense Few-shot Medical Image Segmentation Model Training Pipeline (DenseMP) that capitalizes on unsupervised dense pre-training. DenseMP is composed of two distinct stages: (1) segmentation-aware dense contrastive pre-training, and (2) few-shot-aware superpixel guided dense pre-training. These stages collaboratively yield a pre-trained initial model specifically designed for few-shot medical image segmentation, which can subsequently be fine-tuned on the target dataset. Our proposed pipeline significantly enhances the performance of the widely recognized few-shot segmentation model, PA-Net, achieving state-of-the-art results on the Abd-CT and Abd-MRI datasets. Code will be released after acceptance.

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CroBIM-U: Uncertainty-Driven Referring Remote Sensing Image Segmentation

Referring remote sensing image segmentation aims to localize specific targets described by natural language within complex overhead imagery. However, due to extreme scale variations, dense similar distractors, and intricate boundary structures, the reliability of cross-modal alignment exhibits significant \textbf{spatial non-uniformity}. Existing methods typically employ uniform fusion and refinement strategies across the entire image, which often introduces unnecessary linguistic perturbations in visually clear regions while failing to provide sufficient disambiguation in confused areas. To address this, we propose an \textbf{uncertainty-guided framework} that explicitly leverages a pixel-wise \textbf{referring uncertainty map} as a spatial prior to orchestrate adaptive inference. Specifically, we introduce a plug-and-play \textbf{Referring Uncertainty Scorer (RUS)}, which is trained via an online error-consistency supervision strategy to interpretably predict the spatial distribution of referential ambiguity. Building on this prior, we design two plug-and-play modules: 1) \textbf{Uncertainty-Gated Fusion (UGF)}, which dynamically modulates language injection strength to enhance constraints in high-uncertainty regions while suppressing noise in low-uncertainty ones; and 2) \textbf{Uncertainty-Driven Local Refinement (UDLR)}, which utilizes uncertainty-derived soft masks to focus refinement on error-prone boundaries and fine details. Extensive experiments demonstrate that our method functions as a unified, plug-and-play solution that significantly improves robustness and geometric fidelity in complex remote sensing scenes without altering the backbone architecture.

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Linkage between piecewise constant Mumford-Shah model and ROF model and its virtue in image segmentation

The piecewise constant Mumford-Shah (PCMS) model and the Rudin-Osher-Fatemi (ROF) model are two important variational models in image segmentation and image restoration, respectively. In this paper, we explore a linkage between these models. We prove that for the two-phase segmentation problem a partial minimizer of the PCMS model can be obtained by thresholding the minimizer of the ROF model. A similar linkage is still valid for multiphase segmentation under specific assumptions. Thus it opens a new segmentation paradigm: image segmentation can be done via image restoration plus thresholding. This new paradigm, which circumvents the innate non-convex property of the PCMS model, therefore improves the segmentation performance in both efficiency (much faster than state-of-the-art methods based on PCMS model, particularly when the phase number is high) and effectiveness (producing segmentation results with better quality) due to the flexibility of the ROF model in tackling degraded images, such as noisy images, blurry images or images with information loss. As a by-product of the new paradigm, we derive a novel segmentation method, called thresholded-ROF (T-ROF) method, to illustrate the virtue of managing image segmentation through image restoration techniques. The convergence of the T-ROF method is proved, and elaborate experimental results and comparisons are presented.

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Tumor-Centered Patching for Enhanced Medical Image Segmentation

The realm of medical image diagnosis has advanced significantly with the integration of computer-aided diagnosis and surgical systems. However, challenges persist, particularly in achieving precise image segmentation. While deep learning techniques show potential, obstacles like limited resources, slow convergence, and class imbalance impede their effectiveness. Traditional patch-based methods, though common, struggle to capture intricate tumor boundaries and often lead to redundant samples, compromising computational efficiency and feature quality. To tackle these issues, this research introduces an innovative approach centered on the tumor itself for patch-based image analysis. This novel tumor-centered patching method aims to address the class imbalance and boundary deficiencies, enabling focused and accurate tumor segmentation. By aligning patches with the tumor's anatomical context, this technique enhances feature extraction accuracy and reduces computational load. Experimental results demonstrate improved class imbalance, with segmentation scores of 0.78, 0.76, and 0.71 for whole, core, and enhancing tumors, respectively using a lightweight simple U-Net. This approach shows potential for enhancing medical image segmentation and improving computer-aided diagnosis systems.

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SSFMamba: Learning Symmetry-driven Spatial-Frequency Modeling for Physically Consistent 3D Medical Image Segmentation

Accurate 3D medical image segmentation requires a delicate balance between fine-grained local details and global contextual understanding. While spatial-domain models often struggle with long-range dependencies, existing frequency-based approaches frequently overlook intrinsic spectral properties such as Hermitian symmetry, leading to suboptimal feature integration. In this paper, we propose SSFMamba, a Mamba based Symmetry-driven Spatial-Frequency fusion framework tailored for 3D medical imaging. Our architecture employs a complementary dual-branch design: the spatial branch preserves intricate anatomical textures, while the frequency branch captures global contextual dependencies in the frequency domain. A core innovation is the 3D Multi-Directional Scanning Mechanism (MDSM), which integrates Hermitian symmetry with the causal nature of State Space Models (SSMs) to enable direction-aware global modeling. Crucially, by shifting the modeling focus to frequency-domain spectral components, SSFMamba captures the underlying structural characteristics of anatomical tissues. This leads to a highly adaptable framework that excels in both MRI and CT applications, regardless of the significant variations in intensity distributions. Extensive evaluations on the BraTS2020, BraTS2023, and BTCV datasets demonstrate that SSFMamba consistently outperforms state-of-the-art methods. Notably, our approach achieves exceptional performance on low-contrast organs such as the pancreas (81.97% Dice), underscoring its potential as a unified and physically consistent perception framework for diverse 3D clinical applications.

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Global Image Segmentation Process using Machine Learning algorithm & Convolution Neural Network method for Self- Driving Vehicles

In autonomous Vehicles technology Image segmentation was a major problem in visual perception. This image segmentation process is mainly used in medical applications. Here we adopted an image segmentation process to visual perception tasks for predicting the agents on the surrounding environment, identifying the road boundaries and tracking the line markings. Main objective of the paper is to divide the input images using the image segmentation process and Convolution Neural Network method for efficient results of visual perception. For Sampling assume a local city data-set samples and validation process done in Jupyter Notebook using Python language. We proposed this image segmentation method planning to standard and further the development of state-of-the art methods for visual inspection system understanding. The experimental results achieves 73% mean IOU. Our method also achieves 90 FPS inference speed and using a NVDIA GeForce GTX 1050 GPU.

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DFormer: Diffusion-guided Transformer for Universal Image Segmentation

This paper introduces an approach, named DFormer, for universal image segmentation. The proposed DFormer views universal image segmentation task as a denoising process using a diffusion model. DFormer first adds various levels of Gaussian noise to ground-truth masks, and then learns a model to predict denoising masks from corrupted masks. Specifically, we take deep pixel-level features along with the noisy masks as inputs to generate mask features and attention masks, employing diffusion-based decoder to perform mask prediction gradually. At inference, our DFormer directly predicts the masks and corresponding categories from a set of randomly-generated masks. Extensive experiments reveal the merits of our proposed contributions on different image segmentation tasks: panoptic segmentation, instance segmentation, and semantic segmentation. Our DFormer outperforms the recent diffusion-based panoptic segmentation method Pix2Seq-D with a gain of 3.6% on MS COCO val2017 set. Further, DFormer achieves promising semantic segmentation performance outperforming the recent diffusion-based method by 2.2% on ADE20K val set. Our source code and models will be publicly on https://github.com/cp3wan/DFormer

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Semi-KAN: KAN Provides an Effective Representation for Semi-Supervised Learning in Medical Image Segmentation

Deep learning-based medical image segmentation has shown remarkable success; however, it typically requires extensive pixel-level annotations, which are both expensive and time-intensive. Semi-supervised medical image segmentation (SSMIS) offers a viable alternative, driven by advancements in CNNs and ViTs. However, these networks often rely on single fixed activation functions and linear modeling patterns, limiting their ability to effectively learn robust representations. Given the limited availability of labeled date, achieving robust representation learning becomes crucial. Inspired by Kolmogorov-Arnold Networks (KANs), we propose Semi-KAN, which leverages the untapped potential of KANs to enhance backbone architectures for representation learning in SSMIS. Our findings indicate that: (1) compared to networks with fixed activation functions, KANs exhibit superior representation learning capabilities with fewer parameters, and (2) KANs excel in high-semantic feature spaces. Building on these insights, we integrate KANs into tokenized intermediate representations, applying them selectively at the encoder's bottleneck and the decoder's top layers within a U-Net pipeline to extract high-level semantic features. Although learnable activation functions improve feature expansion, they introduce significant computational overhead with only marginal performance gains. To mitigate this, we reduce the feature dimensions and employ horizontal scaling to capture multiple pattern representations. Furthermore, we design a multi-branch U-Net architecture with uncertainty estimation to effectively learn diverse pattern representations. Extensive experiments on four public datasets demonstrate that Semi-KAN surpasses baseline networks, utilizing fewer KAN layers and lower computational cost, thereby underscoring the potential of KANs as a promising approach for SSMIS.

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Quantization of Fully Convolutional Networks for Accurate Biomedical Image Segmentation

With pervasive applications of medical imaging in health-care, biomedical image segmentation plays a central role in quantitative analysis, clinical diagno- sis, and medical intervention. Since manual anno- tation su ers limited reproducibility, arduous e orts, and excessive time, automatic segmentation is desired to process increasingly larger scale histopathological data. Recently, deep neural networks (DNNs), par- ticularly fully convolutional networks (FCNs), have been widely applied to biomedical image segmenta- tion, attaining much improved performance. At the same time, quantization of DNNs has become an ac- tive research topic, which aims to represent weights with less memory (precision) to considerably reduce memory and computation requirements of DNNs while maintaining acceptable accuracy. In this paper, we apply quantization techniques to FCNs for accurate biomedical image segmentation. Unlike existing litera- ture on quantization which primarily targets memory and computation complexity reduction, we apply quan- tization as a method to reduce over tting in FCNs for better accuracy. Speci cally, we focus on a state-of- the-art segmentation framework, suggestive annotation [22], which judiciously extracts representative annota- tion samples from the original training dataset, obtain- ing an e ective small-sized balanced training dataset. We develop two new quantization processes for this framework: (1) suggestive annotation with quantiza- tion for highly representative training samples, and (2) network training with quantization for high accuracy. Extensive experiments on the MICCAI Gland dataset show that both quantization processes can improve the segmentation performance, and our proposed method exceeds the current state-of-the-art performance by up to 1%. In addition, our method has a reduction of up to 6.4x on memory usage.

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Where to Begin? From Random to Foundation Model Instructed Initialization in Federated Learning for Medical Image Segmentation

In medical image analysis, Federated Learning (FL) stands out as a key technology that enables privacy-preserved, decentralized data processing, crucial for handling sensitive medical data. Currently, most FL models employ random initialization, which has been proven effective in various instances. However, given the unique challenges posed by non-IID (independently and identically distributed) data in FL, we propose a novel perspective: exploring the impact of using the foundation model with enormous pre-trained knowledge, such as the Segment Anything Model (SAM), as an instructive teacher for FL model initialization in medical image segmentation task. This work for the first time attempts to utilize the foundation model as an instructive teacher for initialization in FL, assessing its impact on the performance of FL models, especially in non-IID data scenarios. Our empirical evaluation on chest x-ray lung segmentation showcases that FL with foundation model instructed initialization not only achieves faster convergence but also improves performance in complex data contexts. These findings offer a new perspective for model initialization in FL.

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TransResNet: Integrating the Strengths of ViTs and CNNs for High Resolution Medical Image Segmentation via Feature Grafting

High-resolution images are preferable in medical imaging domain as they significantly improve the diagnostic capability of the underlying method. In particular, high resolution helps substantially in improving automatic image segmentation. However, most of the existing deep learning-based techniques for medical image segmentation are optimized for input images having small spatial dimensions and perform poorly on high-resolution images. To address this shortcoming, we propose a parallel-in-branch architecture called TransResNet, which incorporates Transformer and CNN in a parallel manner to extract features from multi-resolution images independently. In TransResNet, we introduce Cross Grafting Module (CGM), which generates the grafted features, enriched in both global semantic and low-level spatial details, by combining the feature maps from Transformer and CNN branches through fusion and self-attention mechanism. Moreover, we use these grafted features in the decoding process, increasing the information flow for better prediction of the segmentation mask. Extensive experiments on ten datasets demonstrate that TransResNet achieves either state-of-the-art or competitive results on several segmentation tasks, including skin lesion, retinal vessel, and polyp segmentation. The source code and pre-trained models are available at https://github.com/Sharifmhamza/TransResNet.

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