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arXiv2026

Localization-Infused Vision-Language Semantic Fusion for Text-Guided Medical Image Segmentation

Medical image segmentation is essential for modern computer-aided medicine. Recently, text-guided segmentation has shown promise by incorporating clinician-formulated textual reports as semantic guidance for image segmentation. These textual reports contain language descriptions about the appearance, location, and neighboring anatomy of segmentation targets, providing explicit guidance for target localization and delineation. Existing text-guided segmentation methods typically extract textual semantics implicitly through a pretrained text encoder and then integrate vision-language semantics via straightforward image-text feature fusion. However, these methods do not explicitly capture target-oriented information embedded in textual reports, particularly target location, and do not explore multi-level information fusion strategies beyond basic feature-level fusion, limiting the extraction and integration of critical textual semantics. In this study, we propose LoG, a localization-infused vision-language fusion framework for text-guided medical image segmentation. By jointly performing multi-scale target localization tasks, LoG explicitly captures target-oriented vision-language semantics and enables three-level localization-infused semantic fusion: (i) localization-guided feature fusion that directly infuses location-relevant semantics into visual features, (ii) localization-gated attention fusion that redirects multi-scale localization predictions to reinforce critical regions, and (iii) localization-constrained loss fusion that supervises segmentation based on spatial consistency with target localization. Extensive experiments on three well-established benchmark datasets, involving three medical imaging modalities with paired textual reports, demonstrate that LoG consistently outperforms state-of-the-art medical image segmentation methods.

cs.CV↗
arXiv2025

Prototype Contrastive Consistency Learning for Semi-Supervised Medical Image Segmentation

Medical image segmentation is a crucial task in medical image analysis, but it can be very challenging especially when there are less labeled data but with large unlabeled data. Contrastive learning has proven to be effective for medical image segmentation in semi-supervised learning by constructing contrastive samples from partial pixels. However, although previous contrastive learning methods can mine semantic information from partial pixels within images, they ignore the whole context information of unlabeled images, which is very important to precise segmentation. In order to solve this problem, we propose a novel prototype contrastive learning method called Prototype Contrastive Consistency Segmentation (PCCS) for semi-supervised medical image segmentation. The core idea is to enforce the prototypes of the same semantic class to be closer and push the prototypes in different semantic classes far away from each other. Specifically, we construct a signed distance map and an uncertainty map from unlabeled images. The signed distance map is used to construct prototypes for contrastive learning, and then we estimate the prototype uncertainty from the uncertainty map as trade-off among prototypes. In order to obtain better prototypes, based on the student-teacher architecture, a new mechanism named prototype updating prototype is designed to assist in updating the prototypes for contrastive learning. In addition, we propose an uncertainty-consistency loss to mine more reliable information from unlabeled data. Extensive experiments on medical image segmentation demonstrate that PCCS achieves better segmentation performance than the state-of-the-art methods. The code is available at https://github.com/comphsh/PCCS.

cs.CV↗
arXiv2021

TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation

Medical image segmentation is an essential prerequisite for developing healthcare systems, especially for disease diagnosis and treatment planning. On various medical image segmentation tasks, the u-shaped architecture, also known as U-Net, has become the de-facto standard and achieved tremendous success. However, due to the intrinsic locality of convolution operations, U-Net generally demonstrates limitations in explicitly modeling long-range dependency. Transformers, designed for sequence-to-sequence prediction, have emerged as alternative architectures with innate global self-attention mechanisms, but can result in limited localization abilities due to insufficient low-level details. In this paper, we propose TransUNet, which merits both Transformers and U-Net, as a strong alternative for medical image segmentation. On one hand, the Transformer encodes tokenized image patches from a convolution neural network (CNN) feature map as the input sequence for extracting global contexts. On the other hand, the decoder upsamples the encoded features which are then combined with the high-resolution CNN feature maps to enable precise localization. We argue that Transformers can serve as strong encoders for medical image segmentation tasks, with the combination of U-Net to enhance finer details by recovering localized spatial information. TransUNet achieves superior performances to various competing methods on different medical applications including multi-organ segmentation and cardiac segmentation. Code and models are available at https://github.com/Beckschen/TransUNet.

cs.CV↗
arXiv2022

Scaling Open-Vocabulary Image Segmentation with Image-Level Labels

We design an open-vocabulary image segmentation model to organize an image into meaningful regions indicated by arbitrary texts. Recent works (CLIP and ALIGN), despite attaining impressive open-vocabulary classification accuracy with image-level caption labels, are unable to segment visual concepts with pixels. We argue that these models miss an important step of visual grouping, which organizes pixels into groups before learning visual-semantic alignments. We propose OpenSeg to address the above issue while still making use of scalable image-level supervision of captions. First, it learns to propose segmentation masks for possible organizations. Then it learns visual-semantic alignments by aligning each word in a caption to one or a few predicted masks. We find the mask representations are the key to support learning image segmentation from captions, making it possible to scale up the dataset and vocabulary sizes. OpenSeg significantly outperforms the recent open-vocabulary method of LSeg by +19.9 mIoU on PASCAL dataset, thanks to its scalability.

cs.CV↗
arXiv2020

Multi-level Context Gating of Embedded Collective Knowledge for Medical Image Segmentation

Medical image segmentation has been very challenging due to the large variation of anatomy across different cases. Recent advances in deep learning frameworks have exhibited faster and more accurate performance in image segmentation. Among the existing networks, U-Net has been successfully applied on medical image segmentation. In this paper, we propose an extension of U-Net for medical image segmentation, in which we take full advantages of U-Net, Squeeze and Excitation (SE) block, bi-directional ConvLSTM (BConvLSTM), and the mechanism of dense convolutions. (I) We improve the segmentation performance by utilizing SE modules within the U-Net, with a minor effect on model complexity. These blocks adaptively recalibrate the channel-wise feature responses by utilizing a self-gating mechanism of the global information embedding of the feature maps. (II) To strengthen feature propagation and encourage feature reuse, we use densely connected convolutions in the last convolutional layer of the encoding path. (III) Instead of a simple concatenation in the skip connection of U-Net, we employ BConvLSTM in all levels of the network to combine the feature maps extracted from the corresponding encoding path and the previous decoding up-convolutional layer in a non-linear way. The proposed model is evaluated on six datasets DRIVE, ISIC 2017 and 2018, lung segmentation, $PH^2$, and cell nuclei segmentation, achieving state-of-the-art performance.

eess.IV↗
arXiv2024

FedFMS: Exploring Federated Foundation Models for Medical Image Segmentation

Medical image segmentation is crucial for clinical diagnosis. The Segmentation Anything Model (SAM) serves as a powerful foundation model for visual segmentation and can be adapted for medical image segmentation. However, medical imaging data typically contain privacy-sensitive information, making it challenging to train foundation models with centralized storage and sharing. To date, there are few foundation models tailored for medical image deployment within the federated learning framework, and the segmentation performance, as well as the efficiency of communication and training, remain unexplored. In response to these issues, we developed Federated Foundation models for Medical image Segmentation (FedFMS), which includes the Federated SAM (FedSAM) and a communication and training-efficient Federated SAM with Medical SAM Adapter (FedMSA). Comprehensive experiments on diverse datasets are conducted to investigate the performance disparities between centralized training and federated learning across various configurations of FedFMS. The experiments revealed that FedFMS could achieve performance comparable to models trained via centralized training methods while maintaining privacy. Furthermore, FedMSA demonstrated the potential to enhance communication and training efficiency. Our model implementation codes are available at https://github.com/LIU-YUXI/FedFMS.

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arXiv2025

GCA-ResUNet:Image segmentation in medical images using grouped coordinate attention

Medical image segmentation underpins computer-aided diagnosis and therapy by supporting clinical diagnosis, preoperative planning, and disease monitoring. While U-Net style convolutional neural networks perform well due to their encoder-decoder structures with skip connections, they struggle to capture long-range dependencies. Transformer-based variants address global context but often require heavy computation and large training datasets. This paper proposes GCA-ResUNet, an efficient segmentation network that integrates Grouped Coordinate Attention (GCA) into ResNet-50 residual blocks. GCA uses grouped coordinate modeling to jointly encode global dependencies across channels and spatial locations, strengthening feature representation and boundary delineation while adding minimal parameter and FLOP overhead compared with self-attention. On the Synapse dataset, GCA-ResUNet achieves a Dice score of 86.11%, and on the ACDC dataset, it reaches 92.64%, surpassing several state-of-the-art baselines while maintaining fast inference and favorable computational efficiency. These results indicate that GCA offers a practical way to enhance convolutional architectures with global modeling capability, enabling high-accuracy and resource-efficient medical image segmentation.

cs.CV↗
arXiv2020

SAUNet: Shape Attentive U-Net for Interpretable Medical Image Segmentation

Medical image segmentation is a difficult but important task for many clinical operations such as cardiac bi-ventricular volume estimation. More recently, there has been a shift to utilizing deep learning and fully convolutional neural networks (CNNs) to perform image segmentation that has yielded state-of-the-art results in many public benchmark datasets. Despite the progress of deep learning in medical image segmentation, standard CNNs are still not fully adopted in clinical settings as they lack robustness and interpretability. Shapes are generally more meaningful features than solely textures of images, which are features regular CNNs learn, causing a lack of robustness. Likewise, previous works surrounding model interpretability have been focused on post hoc gradient-based saliency methods. However, gradient-based saliency methods typically require additional computations post hoc and have been shown to be unreliable for interpretability. Thus, we present a new architecture called Shape Attentive U-Net (SAUNet) which focuses on model interpretability and robustness. The proposed architecture attempts to address these limitations by the use of a secondary shape stream that captures rich shape-dependent information in parallel with the regular texture stream. Furthermore, we suggest multi-resolution saliency maps can be learned using our dual-attention decoder module which allows for multi-level interpretability and mitigates the need for additional computations post hoc. Our method also achieves state-of-the-art results on the two large public cardiac MRI image segmentation datasets of SUN09 and AC17.

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arXiv2021

LeViT-UNet: Make Faster Encoders with Transformer for Medical Image Segmentation

Medical image segmentation plays an essential role in developing computer-assisted diagnosis and therapy systems, yet still faces many challenges. In the past few years, the popular encoder-decoder architectures based on CNNs (e.g., U-Net) have been successfully applied in the task of medical image segmentation. However, due to the locality of convolution operations, they demonstrate limitations in learning global context and long-range spatial relations. Recently, several researchers try to introduce transformers to both the encoder and decoder components with promising results, but the efficiency requires further improvement due to the high computational complexity of transformers. In this paper, we propose LeViT-UNet, which integrates a LeViT Transformer module into the U-Net architecture, for fast and accurate medical image segmentation. Specifically, we use LeViT as the encoder of the LeViT-UNet, which better trades off the accuracy and efficiency of the Transformer block. Moreover, multi-scale feature maps from transformer blocks and convolutional blocks of LeViT are passed into the decoder via skip-connection, which can effectively reuse the spatial information of the feature maps. Our experiments indicate that the proposed LeViT-UNet achieves better performance comparing to various competing methods on several challenging medical image segmentation benchmarks including Synapse and ACDC. Code and models will be publicly available at https://github.com/apple1986/LeViT_UNet.

cs.CV↗
arXiv2026

Med-URWKV†: Toward Enhanced Pretrained Pure VRWKV Models for Medical Image Segmentation

Medical image segmentation is a fundamental task in computer-aided diagnosis and treatment. Existing approaches based on CNNs, ViTs, Mamba, and hybrid models still suffer from limitations such as restricted receptive fields, high computational cost, or insufficient accuracy. Recently, Vision Receptive-field Weighted Key-Value (VRWKV) models have emerged as a promising alternative,delivering strong long-range dependency modeling for visual tasks. However, current studies on VRWKV-based medical image segmentation mainly focus on hybrid architectures trained from scratch, while the potential of large-scale pretrained pure VRWKV models remains unexplored. In this work, we systematically investigate the effectiveness of pure VRWKV architectures for medical image segmentation. We construct Med-URWKV-T and Med-URWKV-S by reusing pretrained VRWKV encoders at different scales and pairing them with pure VRWKV decoders, enabling a comprehensive evaluation of pretrained pure VRWKV models in this domain. To further enhance performance, we propose two VRWKV-compatible modules: a Frequency-Aware Wavelet Attention (FAWA) module, which exploits wavelet transforms to capture edge details and structural characteristics, and a Multi-Scale Channel Fusion (MSCF) module, which integrates multi-scale features to strengthen informative channel representations. By incorporating them into Med-URWKV-T, we obtain the enhanced model Med-URWKV†. Extensive experiments on five medical image segmentation datasets demonstrate that Med-URWKV achieves performance comparable to or superior to state-of-the-art methods and carefully designed hybrid VRWKV architectures. Moreover, Med-URWKV† further improves segmentation accuracy, surpassing Med-URWKV-S while using only half of its parameter count, and achieves the highest average Dice similarity coefficient of 88.00%. The codes will be released.

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arXiv2026

MedCLIPSeg: Probabilistic Vision-Language Adaptation for Data-Efficient and Generalizable Medical Image Segmentation

Medical image segmentation remains challenging due to limited annotations for training, ambiguous anatomical features, and domain shifts. While vision-language models such as CLIP offer strong cross-modal representations, their potential for dense, text-guided medical image segmentation remains underexplored. We present MedCLIPSeg, a novel framework that adapts CLIP for robust, data-efficient, and uncertainty-aware medical image segmentation. Our approach leverages patch-level CLIP embeddings through probabilistic cross-modal attention, enabling bidirectional interaction between image and text tokens and explicit modeling of predictive uncertainty. Together with a soft patch-level contrastive loss that encourages more nuanced semantic learning across diverse textual prompts, MedCLIPSeg effectively improves data efficiency and domain generalizability. Extensive experiments across 16 datasets spanning five imaging modalities and six organs demonstrate that MedCLIPSeg outperforms prior methods in accuracy, efficiency, and robustness, while providing interpretable uncertainty maps that highlight local reliability of segmentation results. This work demonstrates the potential of probabilistic vision-language modeling for text-driven medical image segmentation.

cs.CV↗
arXiv2023

A Recent Survey of Vision Transformers for Medical Image Segmentation

Medical image segmentation plays a crucial role in various healthcare applications, enabling accurate diagnosis, treatment planning, and disease monitoring. Traditionally, convolutional neural networks (CNNs) dominated this domain, excelling at local feature extraction. However, their limitations in capturing long-range dependencies across image regions pose challenges for segmenting complex, interconnected structures often encountered in medical data. In recent years, Vision Transformers (ViTs) have emerged as a promising technique for addressing the challenges in medical image segmentation. Their multi-scale attention mechanism enables effective modeling of long-range dependencies between distant structures, crucial for segmenting organs or lesions spanning the image. Additionally, ViTs' ability to discern subtle pattern heterogeneity allows for the precise delineation of intricate boundaries and edges, a critical aspect of accurate medical image segmentation. However, they do lack image-related inductive bias and translational invariance, potentially impacting their performance. Recently, researchers have come up with various ViT-based approaches that incorporate CNNs in their architectures, known as Hybrid Vision Transformers (HVTs) to capture local correlation in addition to the global information in the images. This survey paper provides a detailed review of the recent advancements in ViTs and HVTs for medical image segmentation. Along with the categorization of ViT and HVT-based medical image segmentation approaches, we also present a detailed overview of their real-time applications in several medical image modalities. This survey may serve as a valuable resource for researchers, healthcare practitioners, and students in understanding the state-of-the-art approaches for ViT-based medical image segmentation.

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arXiv2024

MAPUNetR: A Hybrid Vision Transformer and U-Net Architecture for Efficient and Interpretable Medical Image Segmentation

Medical image segmentation is pivotal in healthcare, enhancing diagnostic accuracy, informing treatment strategies, and tracking disease progression. This process allows clinicians to extract critical information from visual data, enabling personalized patient care. However, developing neural networks for segmentation remains challenging, especially when preserving image resolution, which is essential in detecting subtle details that influence diagnoses. Moreover, the lack of transparency in these deep learning models has slowed their adoption in clinical practice. Efforts in model interpretability are increasingly focused on making these models' decision-making processes more transparent. In this paper, we introduce MAPUNetR, a novel architecture that synergizes the strengths of transformer models with the proven U-Net framework for medical image segmentation. Our model addresses the resolution preservation challenge and incorporates attention maps highlighting segmented regions, increasing accuracy and interpretability. Evaluated on the BraTS 2020 dataset, MAPUNetR achieved a dice score of 0.88 and a dice coefficient of 0.92 on the ISIC 2018 dataset. Our experiments show that the model maintains stable performance and potential as a powerful tool for medical image segmentation in clinical practice.

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arXiv2025

MGFI-Net: A Multi-Grained Feature Integration Network for Enhanced Medical Image Segmentation

Medical image segmentation plays a crucial role in various clinical applications. A major challenge in medical image segmentation is achieving accurate delineation of regions of interest in the presence of noise, low contrast, or complex anatomical structures. Existing segmentation models often neglect the integration of multi-grained information and fail to preserve edge details, which are critical for precise segmentation. To address these challenges, we propose a novel image semantic segmentation model called the Multi-Grained Feature Integration Network (MGFI-Net). Our MGFI-Net is designed with two dedicated modules to tackle these issues. First, to enhance segmentation accuracy, we introduce a Multi-Grained Feature Extraction Module, which leverages hierarchical relationships between different feature scales to selectively focus on the most relevant information. Second, to preserve edge details, we incorporate an Edge Enhancement Module that effectively retains and integrates boundary information to refine segmentation results. Extensive experiments demonstrate that MGFI-Net not only outperforms state-of-the-art methods in terms of segmentation accuracy but also achieves superior time efficiency, establishing it as a leading solution for real-time medical image segmentation.

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arXiv2015

Comparing the Performance of L*A*B* and HSV Color Spaces with Respect to Color Image Segmentation

Color image segmentation is a very emerging topic for image processing research. Since it has the ability to present the result in a way that is much more close to the human yes perceive, so todays more research is going on this area. Choosing a proper color space is a very important issue for color image segmentation process. Generally LAB and HSV are the two frequently chosen color spaces. In this paper a comparative analysis is performed between these two color spaces with respect to color image segmentation. For measuring their performance, we consider the parameters: mse and psnr . It is found that HSV color space is performing better than LAB.

cs.CV↗
arXiv2023

Performance Analysis of UNet and Variants for Medical Image Segmentation

Medical imaging plays a crucial role in modern healthcare by providing non-invasive visualisation of internal structures and abnormalities, enabling early disease detection, accurate diagnosis, and treatment planning. This study aims to explore the application of deep learning models, particularly focusing on the UNet architecture and its variants, in medical image segmentation. We seek to evaluate the performance of these models across various challenging medical image segmentation tasks, addressing issues such as image normalization, resizing, architecture choices, loss function design, and hyperparameter tuning. The findings reveal that the standard UNet, when extended with a deep network layer, is a proficient medical image segmentation model, while the Res-UNet and Attention Res-UNet architectures demonstrate smoother convergence and superior performance, particularly when handling fine image details. The study also addresses the challenge of high class imbalance through careful preprocessing and loss function definitions. We anticipate that the results of this study will provide useful insights for researchers seeking to apply these models to new medical imaging problems and offer guidance and best practices for their implementation.

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arXiv2025

Pre- and Post-Treatment Glioma Segmentation with the Medical Imaging Segmentation Toolkit

Medical image segmentation continues to advance rapidly, yet rigorous comparison between methods remains challenging due to a lack of standardized and customizable tooling. In this work, we present the current state of the Medical Imaging Segmentation Toolkit (MIST), with a particular focus on its flexible and modular postprocessing framework designed for the BraTS 2025 pre- and post-treatment glioma segmentation challenge. Since its debut in the 2024 BraTS adult glioma post-treatment segmentation challenge, MIST's postprocessing module has been significantly extended to support a wide range of transforms, including removal or replacement of small objects, extraction of the largest connected components, and morphological operations such as hole filling and closing. These transforms can be composed into user-defined strategies, enabling fine-grained control over the final segmentation output. We evaluate three such strategies - ranging from simple small-object removal to more complex, class-specific pipelines - and rank their performance using the BraTS ranking protocol. Our results highlight how MIST facilitates rapid experimentation and targeted refinement, ultimately producing high-quality segmentations for the BraTS 2025 challenge. MIST remains open source and extensible, supporting reproducible and scalable research in medical image segmentation.

cs.CV↗
arXiv2025

SegVol: Universal and Interactive Volumetric Medical Image Segmentation

Precise image segmentation provides clinical study with instructive information. Despite the remarkable progress achieved in medical image segmentation, there is still an absence of a 3D foundation segmentation model that can segment a wide range of anatomical categories with easy user interaction. In this paper, we propose a 3D foundation segmentation model, named SegVol, supporting universal and interactive volumetric medical image segmentation. By scaling up training data to 90K unlabeled Computed Tomography (CT) volumes and 6K labeled CT volumes, this foundation model supports the segmentation of over 200 anatomical categories using semantic and spatial prompts. To facilitate efficient and precise inference on volumetric images, we design a zoom-out-zoom-in mechanism. Extensive experiments on 22 anatomical segmentation tasks verify that SegVol outperforms the competitors in 19 tasks, with improvements up to 37.24% compared to the runner-up methods. We demonstrate the effectiveness and importance of specific designs by ablation study. We expect this foundation model can promote the development of volumetric medical image analysis. The model and code are publicly available at: https://github.com/BAAI-DCAI/SegVol.

cs.CV↗