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arXiv · 0712.1063

Nucleosome Switching

David J. Schwab·Robijn F. Bruinsma·Joseph Rudnick·Jonathan Widom
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Abstract

We present a statistical-mechanical analysis of the positioning of nucleosomes along one of the chromosomes of yeast DNA as a function of the strength of the binding potential and of the chemical potential of the nucleosomes. We find a significant density of two-level nucleosome switching regions where, as a function of the chemical potential, the nucleosome distribution undergoes a "micro" first-order transition. The location of these nucleosome switches shows a strong correlation with the location of transcription-factor binding sites.

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David J. Schwab, Robijn F. Bruinsma, Joseph Rudnick, Jonathan Widom. 2007-12-06. Nucleosome Switching. https://doi.org/10.1103/physrevlett.100.228105

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