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arXiv · 0802.0224

Optimized free energies from bidirectional single-molecule force spectroscopy

David D. L. Minh·Artur B. Adib
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Abstract

An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy - valid for biasing potentials of arbitrary stiffness - are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies.

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David D. L. Minh, Artur B. Adib. 2008-04-10. Optimized free energies from bidirectional single-molecule force spectroscopy. https://doi.org/10.1103/physrevlett.100.180602

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