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arXiv · 1101.1797

The thermal denaturation of DNA studied with neutron scattering

Andrew Wildes·Nikos Theodorakopoulos·Jessica Valle Orero·Santiago Cuesta-Lopez·Jean-Luc Garden·Michel Peyrard
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Abstract

The melting transition of deoxyribonucleic acid (DNA), whereby the strands of the double helix structure completely separate at a certain temperature, has been characterized using neutron scattering. A Bragg peak from B-form fibre DNA has been measured as a function of temperature, and its widths and integrated intensities have been interpreted using the Peyrard-Bishop-Dauxois (PBD) model with only one free parameter. The experiment is unique, as it gives spatial correlation along the molecule through the melting transition where other techniques cannot.

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Andrew Wildes, Nikos Theodorakopoulos, Jessica Valle Orero, Santiago Cuesta-Lopez, Jean-Luc Garden, Michel Peyrard. 2011-01-10. The thermal denaturation of DNA studied with neutron scattering. https://doi.org/10.1103/physrevlett.106.048101

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