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arXiv · 1204.4341

Noise-induced metastability in biochemical networks

Tommaso Biancalani·Tim Rogers·Alan J. McKane
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Abstract

Intra-cellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different timescales are general features of a broad class of autocatalyic reaction networks, and moreover, that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade.

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Tommaso Biancalani, Tim Rogers, Alan J. McKane. 2012-08-01. Noise-induced metastability in biochemical networks. https://doi.org/10.1103/physreve.86.010106

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