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arXiv · 1401.7724

Prediction of heart rate response to conclusion of spontaneous breathing trial by fluctuation dissipation theory

Man Chen·Liang Ren Niestemski·Robert Prevost·Michael McRae·Sharath Cholleti·Gabriel Najarro·Timothy G. Buchman·Michael W. Deem
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Abstract

The non-equilibrium fluctuation dissipation theorem is applied to predict how critically ill patients respond to treatment, based upon data currently collected by standard hospital monitoring devices. This framework is demonstrated on a common procedure in critical care: the spontaneous breathing trial. It is shown that the responses of groups of similar patients to the spontaneous breathing trial can be predicted by the non-equilibrium fluctuation dissipation approach. This mathematical framework, when fully formed and applied to other clinical interventions, may serve as part of the basis for personalized critical care.

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Man Chen, Liang Ren Niestemski, Robert Prevost, Michael McRae, Sharath Cholleti, Gabriel Najarro, Timothy G. Buchman, Michael W. Deem. 2014-01-30. Prediction of heart rate response to conclusion of spontaneous breathing trial by fluctuation dissipation theory. https://doi.org/10.1088/1478-3975/10/1/016006

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