On the coherent behavior of pancreatic beta cell clusters

Alessandro Loppini; Antonio Capolupo; Christian Cherubini; Alessio Gizzi; Marta Bertolaso; Simonetta Filippi; Giuseppe Vitiello

doi:10.1016/j.physleta.2014.09.041

arXiv · 1407.7741

On the coherent behavior of pancreatic beta cell clusters

Alessandro Loppini·Antonio Capolupo·Christian Cherubini·Alessio Gizzi·Marta Bertolaso·Simonetta Filippi·Giuseppe Vitiello

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Abstract

Beta cells in pancreas represent an example of coupled biological oscillators which via communication pathways, are able to synchronize their electrical activity, giving rise to pulsatile insulin release. In this work we numerically analyze scale free self-similarity features of membrane voltage signal power density spectrum, through a stochastic dynamical model for beta cells in the islets of Langerhans fine tuned on mouse experimental data. Adopting the algebraic approach of coherent state formalism, we show how coherent molecular domains can arise from proper functional conditions leading to a parallelism with "phase transition" phenomena of field theory.

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Alessandro Loppini, Antonio Capolupo, Christian Cherubini, Alessio Gizzi, Marta Bertolaso, Simonetta Filippi, Giuseppe Vitiello. 2014-07-29. On the coherent behavior of pancreatic beta cell clusters. https://doi.org/10.1016/j.physleta.2014.09.041

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