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arXiv · 1411.3690

A novel joint location-scale testing framework for improved detection of variants with main or interaction effects

David Soave·Andrew Paterson·Lisa Strug·Lei Sun
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Abstract

We propose a novel and easy-to-implement joint location-scale association testing procedure that can account for complex genetic architecture without explicitly modeling interaction effects, and is suitable for large-scale whole-genome scans and meta-analyses. We focus on Fisher's method and use it to combine evidence from the standard location test and the more recent scale test, and we describe its use for single-variant, gene-set and pathway association analyses.

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David Soave, Andrew Paterson, Lisa Strug, Lei Sun. 2014-11-13. A novel joint location-scale testing framework for improved detection of variants with main or interaction effects. https://arxiv.org/abs/1411.3690

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