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arXiv · 1411.6144

False discovery rate smoothing

Wesley Tansey·Oluwasanmi Koyejo·Russell A. Poldrack·James G. Scott
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Abstract

We present false discovery rate smoothing, an empirical-Bayes method for exploiting spatial structure in large multiple-testing problems. FDR smoothing automatically finds spatially localized regions of significant test statistics. It then relaxes the threshold of statistical significance within these regions, and tightens it elsewhere, in a manner that controls the overall false-discovery rate at a given level. This results in increased power and cleaner spatial separation of signals from noise. The approach requires solving a non-standard high-dimensional optimization problem, for which an efficient augmented-Lagrangian algorithm is presented. In simulation studies, FDR smoothing exhibits state-of-the-art performance at modest computational cost. In particular, it is shown to be far more robust than existing methods for spatially dependent multiple testing. We also apply the method to a data set from an fMRI experiment on spatial working memory, where it detects patterns that are much more biologically plausible than those detected by standard FDR-controlling methods. All code for FDR smoothing is publicly available in Python and R.

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Wesley Tansey, Oluwasanmi Koyejo, Russell A. Poldrack, James G. Scott. 2014-11-22. False discovery rate smoothing. https://arxiv.org/abs/1411.6144

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