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arXiv · 1507.04453

Practical biological spread-out Bragg peak design of carbon beam

Chang Hyeuk Kim·Hwa-Ryun Lee·Seduk Chang·Hong Suk Jang·Jeong Hwan Kim·Dong Wook Park·Won Taek Hwang·Tea-Keun Yang
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Abstract

The carbon beams show more advantages on the biological properties compared with proton beams in radiation therapy. The carbon beam shows high linear energy transfer (LET) to medium and it increases the relative biological effectiveness (RBE). To design spread-out Bragg peak (SOBP) of biological dose using carbon beam, a practical method was purposed by using the linear-quadratic (LQ) model and Geant4 based Monte Carlo simulation code. The various Bragg peak profiles and LET was calculated for each slice at the target region. To generate appropriate biological SOBP, a set of weighting factor, which is a power function in terms of energy step, was applied to the obtained each physical dose. The designed biological SOBP showed 1.34 % of uniformity.

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Chang Hyeuk Kim, Hwa-Ryun Lee, Seduk Chang, Hong Suk Jang, Jeong Hwan Kim, Dong Wook Park, Won Taek Hwang, Tea-Keun Yang. 2015-07-16. Practical biological spread-out Bragg peak design of carbon beam. https://arxiv.org/abs/1507.04453

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