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arXiv · 1508.02601

mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision

Xiao-Jun Tian·Hang Zhang·Jingyu Zhang·Jianhua Xing
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Abstract

miRNAs serve as crucial post-transcriptional regulators in various essential cell fate decision. However, the contribution of the mRNA-miRNA mutual regulation to bistability is not fully understood. Here, we built a set of mathematical models of mRNA-miRNA interactions and systematically analyzed the sensitivity of response curves under various conditions. First, we found that mRNA-miRNA reciprocal regulation could manifest ultrasensitivity to subserve the generation of bistability when equipped with a positive feedback loop. Second, the region of bistability is expanded by a stronger competing mRNA (ceRNA). Interesting, bistability can be emerged without feedback loop if multiple miRNA binding sites exist on a target mRNA. Thus, we demonstrated the importance of simple mRNA-miRNA reciprocal regulation in cell fate decision.

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Xiao-Jun Tian, Hang Zhang, Jingyu Zhang, Jianhua Xing. 2016-09-02. mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision. https://doi.org/10.1002/1873-3468.12379

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