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arXiv · 1603.00698

Label-free optical quantification of structural alterations in Alzheimer's disease

Moosung Lee·Eeksung Lee·JaeHwang Jung·Hyeonseung Yu·Kyoohyun Kim·Shinhwa Lee·Yong Jeong·YongKeun Park
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Abstract

We present a quantitative label-free imaging of mouse whole brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to quantitatively address structural alteration in the brain tissues of mice with Alzheimer's disease.

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Moosung Lee, Eeksung Lee, JaeHwang Jung, Hyeonseung Yu, Kyoohyun Kim, Shinhwa Lee, Yong Jeong, YongKeun Park. 2016-03-02. Label-free optical quantification of structural alterations in Alzheimer's disease. https://arxiv.org/abs/1603.00698

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