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arXiv · 1605.09226

Global existence for a degenerate haptotaxis model of tumor invasion under the go-or-grow dichotomy hypothesis

Anna Zhigun·Christina Surulescu·Alexander Hunt
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Abstract

We propose and study a strongly coupled PDE-ODE-ODE system modeling cancer cell invasion through a tissue network under the go-or-grow hypothesis asserting that cancer cells can either move or proliferate. Hence our setting features two interacting cell populations with their mutual transitions and involves tissue-dependent degenerate diffusion and haptotaxis for the moving subpopulation. The proliferating cells and the tissue evolution are characterized by way of ODEs for the respective densities. We prove the global existence of weak solutions and illustrate the model behaviour by numerical simulations in a two-dimensional setting.

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Anna Zhigun, Christina Surulescu, Alexander Hunt. 2016-05-30. Global existence for a degenerate haptotaxis model of tumor invasion under the go-or-grow dichotomy hypothesis. https://arxiv.org/abs/1605.09226

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