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arXiv · 1607.05353

Structured Models of Cell Migration Incorporating Molecular Binding Processes

Pia Domschke·Dumitru Trucu·Alf Gerisch·Mark A. J. Chaplain
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Abstract

The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with two examples arising from cancer invasion.

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Pia Domschke, Dumitru Trucu, Alf Gerisch, Mark A. J. Chaplain. 2016-07-18. Structured Models of Cell Migration Incorporating Molecular Binding Processes. https://arxiv.org/abs/1607.05353

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