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arXiv · 1703.04343

Diattenuation of Brain Tissue and its Impact on 3D Polarized Light Imaging

Miriam Menzel·Julia Reckfort·Daniel Weigand·Hasan Köse·Katrin Amunts·Markus Axer
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Abstract

3D-Polarized Light Imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue - diattenuation. Based on numerical and experimental studies and a complete analytical description of the optical system, the diattenuation was determined to be below 4 % in rat brain tissue. It was demonstrated that the diattenuation effect has negligible impact on the fiber orientations derived by 3D-PLI. The diattenuation signal, however, was found to highlight different anatomical structures that cannot be distinguished with current imaging techniques, which makes Diattenuation Imaging a promising extension to 3D-PLI.

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Miriam Menzel, Julia Reckfort, Daniel Weigand, Hasan Köse, Katrin Amunts, Markus Axer. 2017-03-13. Diattenuation of Brain Tissue and its Impact on 3D Polarized Light Imaging. https://arxiv.org/abs/1703.04343

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