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arXiv · 1706.08139

Quantification of Healthy Red Blood Cell Removal and Preferential Invasion of Reticulocytes in Macaca mulatta during Plasmodium cynomolgi Infection

Yi H. Yan·Jacob B. Aguilar·Elizabeth D. Trippe·Juan B. Gutierrez
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Abstract

We derived an ordinary differential equation model to capture the disease dynamics during blood-stage malaria. The model was directly derived from an earlier age-structured partial differential equation model. The original model was simplified due to experimental constraints. Here we calibrated the simplified model with experimental data using a multiple objective genetic algorithm. Through the calibration process, we quantified the removal of healthy red blood cells and the the preferential infection of reticulocytes during \textit{Plamodium cynomolgi} infection of \textit{Macaca mulatta}. The calibration of our model also revealed the existence of host erythropoietic response prior to blood stage infection.

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Yi H. Yan, Jacob B. Aguilar, Elizabeth D. Trippe, Juan B. Gutierrez. 2017-06-25. Quantification of Healthy Red Blood Cell Removal and Preferential Invasion of Reticulocytes in Macaca mulatta during Plasmodium cynomolgi Infection. https://arxiv.org/abs/1706.08139

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