arXiv subjects

Jacob B. Aguilar

Publications and source records attributed to Jacob B. Aguilar.

7 recordsLinked to original sources

arXiv2025

On a coupled system of KP-type

A defining characteristic of the Kadomstev-Petviashvili (KP) model equation is that the well-posedness results are subject to the restriction that at all transverse positions, the mass $\int u \,dx = \text{constant independent of $y$}.$ In 2007, for a rather general class of equations of KP type, it was shown that the zero-mass (in $x$) constraint is satisfied at any non-zero time even if it is not satisfied at initial time zero. To remedy this ``odd'' behavior, a model modification is introduced which does not impose non-physical restrictions upon the initial data. In this article, we introduce a new modified KP system, named the Non-KP model equation. After providing a variational derivation of the Non-KP model, we analyze its Hamiltonian evolutionary structure. Furthermore, we prove linear estimates in the Bourgain spaces $X^{s,b}$ corresponding to the integral equation arising from the Duhamel formulation of system.

math.AP↗

arXiv2022

Convergence of Solutions of the BBM and BBM-KP Model Equations

The Benjamin-Bona-Mahony (BBM) equation has proven to be a good approximation for the unidirectional propagation of small amplitude long waves in a channel where the crosswise variation can be safely ignored. The Benjamin-Bona-Mahony-Kadomtsev-Petviashvili (BBM-KP) equation is the regularized version of the Kadomtsev-Petviashvili equation which arises in various modeling scenarios corresponding to nonlinear dispersive waves that propagate principally along the $x$-axis with weak dispersive effects undergone in the direction parallel to the $y$-axis and normal to the primary direction of propagation. There is much literature on mathematical studies regarding these well known equations, however the relationship between the solutions of their underlying pure initial value problems is not fully understood. In this work, it is shown that the solution of the Cauchy problem for the BBM-KP equation converges to the solution of the Cauchy problem for the BBM equation in a suitable function space, provided that the initial data for both equations are close as the transverse variable $y \rightarrow \pm \infty$.

math.AP↗

arXiv2018

Convergence of the solutions of the BBM-KP and the BBM model equations

It is shown that the solution of the Cauchy problem for the BBM-KP equation converges to the solution of the Cauchy problem for the BBM equation in a suitable function space whenever the initial data for both equations are close as the transverse variable $y \rightarrow \pm \infty$.

math.AP↗

arXiv2017

Quantification of Healthy Red Blood Cell Removal and Preferential Invasion of Reticulocytes in Macaca mulatta during Plasmodium cynomolgi Infection

We derived an ordinary differential equation model to capture the disease dynamics during blood-stage malaria. The model was directly derived from an earlier age-structured partial differential equation model. The original model was simplified due to experimental constraints. Here we calibrated the simplified model with experimental data using a multiple objective genetic algorithm. Through the calibration process, we quantified the removal of healthy red blood cells and the the preferential infection of reticulocytes during \textit{Plamodium cynomolgi} infection of \textit{Macaca mulatta}. The calibration of our model also revealed the existence of host erythropoietic response prior to blood stage infection.

q-bio.CB↗

arXiv2017

Introducing Data Primitives: Data Formats for the SKED Framework

Background: The past few years have seen a tremendous increase in the size and complexity of datasets. Scientific and clinical studies must to incorporate datasets that cross multiple spatial and temporal scales to describe a particular phenomenon. The storage and accessibility of these heterogeneous datasets in a way that is useful to researchers and yet extensible to new data types is a major challenge. Methods: In order to overcome these obstacles, we propose the use of data primitives as a common currency between analytical methods. The four data primitives we have identified are time series, text, annotated graph and triangulated mesh, with associated metadata. Using only data primitives to store data and as algorithm input, output, and intermediate results, promotes interoperability, scalability, and reproducibility in scientific studies. Results: Data primitives were used in a multi-omic, multi-scale systems biology study of malaria infection in non-human primates to perform many types of integrative analysis quickly and efficiently. Conclusions: Using data primitives as a common currency for both data storage and for cross talk between analytical methods enables the analysis of complex multi-omic, multi-scale datasets in a reproducible modular fashion.

q-bio.QM↗

arXiv2017

A Vision for Health Informatics: Introducing the SKED Framework.An Extensible Architecture for Scientific Knowledge Extraction from Data

The goals of the Triple Aim of health care and the goals of P4 medicine outline objectives that require a significant health informatics component. However, the goals do not provide specifications about how all of the new individual patient data will be combined in meaningful ways and with data from other sources, like epidemiological data, to promote the health of individuals and society. We seem to have more data than ever before but few resources and means to use it efficiently. We need a general, extensible solution that integrates and homogenizes data of disparate origin, incompatible formats, and multiple spatial and temporal scales. To address this problem, we introduce the Scientific Knowledge Extraction from Data (SKED) architecture, as a technology-agnostic framework to minimize the overhead of data integration, permit reuse of analytical pipelines, and guarantee reproducible quantitative results. The SKED architecture consists of a Resource Allocation Service to locate resources, and the definition of data primitives to simplify and harmonize data. SKED allows automated knowledge discovery and provides a platform for the realization of the major goals of modern health care.

q-bio.QM↗

arXiv2017

An Epidemiological Model of Malaria Accounting for Asymptomatic Carriers

Asymptomatic individuals in the context of malarial disease refers to subjects who carry a parasite load but do not show clinical symptoms. A correct understanding of the influence of asymptomatic individuals on transmission dynamics will provide a comprehensive description of the complex interplay between the definitive host (female \textit{Anopheles} mosquito), intermediate host (human) and agent (\textit{Plasmodium} parasite). The goal of this article is to conduct a rigorous mathematical analysis of a new compartmentalized malaria model accounting for asymptomatic human hosts for the purpose of calculating the basic reproductive number ($\mathcal{R}_0$), and determining the bifurcations that might occur at the onset of disease free equilibrium. A point of departure of this model from others appearing in literature is that the asymptomatic compartment is decomposed into two mutually disjoint sub-compartments by making use of the naturally acquired immunity (NAI) of the population under consideration. After deriving the model, a qualitative analysis is carried out to classify the stability of the equilibria of the system. Our results show that the dynamical system is locally asymptotically stable provided that $\mathcal{R}_0<1$. However this stability is not global, owning to the occurrence of a sub-critical bifurcation in which additional non-trivial sub-threshold equilibrium solutions appear in response to a specified parameter being perturbed. To ensure that the model does not undergo a backward bifurcation, we demand that an auxiliary parameter denoted $Λ<1$ in addition to the threshold constraint $\mathcal{R}_0<1$. The authors hope that this qualitative analysis will fill in the gaps of what is currently known about asymptomatic malaria and aid in designing strategies that assist the further development of malaria control and eradication efforts.

q-bio.PE↗