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arXiv · 1712.08265

Computational Modelling of Aquaporin Co-regulation in Cancer

Junzhe Zhao·Benjamin A. Hall
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Abstract

A computational model of aquaporin regulation in cancer cells has been constructed as a Qualitative Network in the software BioModelAnalyzer (BMA). The model connects some important aquaporins expressed in human cancer to common phenotypes via a number of fundamental, dysregulated signalling pathways. Based on over 60 publications, this model can not only reproduce the results reported in a discrete, qualitative manner, but also reconcile the seemingly incompatible phenotype with research consensus by suggesting molecular mechanisms accountable for it. Novel predictions have also been made by mimicking real-life experiments in the model.

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Junzhe Zhao, Benjamin A. Hall. 2017-12-22. Computational Modelling of Aquaporin Co-regulation in Cancer. https://arxiv.org/abs/1712.08265

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