arXiv subjects

Benjamin A. Hall

Publications and source records attributed to Benjamin A. Hall.

6 recordsLinked to original sources

arXiv2018

Computational Modelling of Aquaporin Co-regulation in Cancer

A computational model of aquaporin regulation in cancer cells has been constructed as a Qualitative Network in the software BioModelAnalyzer (BMA). The model connects some important aquaporins expressed in human cancer to common phenotypes via a number of fundamental, dysregulated signalling pathways. Based on over 60 publications, this model can not only reproduce the results reported in a discrete, qualitative manner, but also reconcile the seemingly incompatible phenotype with research consensus by suggesting molecular mechanisms accountable for it. Novel predictions have also been made by mimicking real-life experiments in the model.

q-bio.MN↗

arXiv2017

Reproducibility in Research: Systems, Infrastructure, Culture

The reproduction and replication of research results has become a major issue for a number of scientific disciplines. In computer science and related computational disciplines such as systems biology, the challenges closely revolve around the ability to implement (and exploit) novel algorithms and models. Taking a new approach from the literature and applying it to a new codebase frequently requires local knowledge missing from the published manuscripts and transient project websites. Alongside this issue, benchmarking, and the lack of open, transparent and fair benchmark sets present another barrier to the verification and validation of claimed results. In this paper, we outline several recommendations to address these issues, driven by specific examples from a range of scientific domains. Based on these recommendations, we propose a high-level prototype open automated platform for scientific software development which effectively abstracts specific dependencies from the individual researcher and their workstation, allowing easy sharing and reproduction of results. This new e-infrastructure for reproducible computational science offers the potential to incentivise a culture change and drive the adoption of new techniques to improve the quality and efficiency -- and thus reproducibility -- of scientific exploration.

cs.SE↗

arXiv2015

Reproducibility as a Technical Specification

Reproducibility of computationally-derived scientific discoveries should be a certainty. As the product of several person-years' worth of effort, results -- whether disseminated through academic journals, conferences or exploited through commercial ventures -- should at some level be expected to be repeatable by other researchers. While this stance may appear to be obvious and trivial, a variety of factors often stand in the way of making it commonplace. Whilst there has been detailed cross-disciplinary discussions of the various social, cultural and ideological drivers and (potential) solutions, one factor which has had less focus is the concept of reproducibility as a technical challenge. Specifically, that the definition of an unambiguous and measurable standard of reproducibility would offer a significant benefit to the wider computational science community. In this paper, we propose a high-level technical specification for a service for reproducibility, presenting cyberinfrastructure and associated workflow for a service which would enable such a specification to be verified and validated. In addition to addressing a pressing need for the scientific community, we further speculate on the potential contribution to the wider software development community of services which automate de novo compilation and testing of code from source. We illustrate our proposed specification and workflow by using the BioModelAnalyzer tool as a running example.

cs.CE↗

arXiv2015

Dear CAV, We Need to Talk About Reproducibility

How many times have you tried to re-implement a past CAV tool paper, and failed? Reliably reproducing published scientific discoveries has been acknowledged as a barrier to scientific progress for some time but there remains only a small subset of software available to support the specific needs of the research community (i.e. beyond generic tools such as source code repositories). In this paper we propose an infrastructure for enabling reproducibility in our community, by automating the build, unit testing and benchmarking of research software.

cs.LO↗

arXiv2014

"Share and Enjoy": Publishing Useful and Usable Scientific Models

The reproduction and replication of reported scientific results is a hot topic within the academic community. The retraction of numerous studies from a wide range of disciplines, from climate science to bioscience, has drawn the focus of many commentators, but there exists a wider socio-cultural problem that pervades the scientific community. Sharing code, data and models often requires extra effort; this is currently seen as a significant overhead that may not be worth the time investment. Automated systems, which allow easy reproduction of results, offer the potential to incentivise a culture change and drive the adoption of new techniques to improve the efficiency of scientific exploration. In this paper, we discuss the value of improved access and sharing of the two key types of results arising from work done in the computational sciences: models and algorithms. We propose the development of an integrated cloud-based system underpinning computational science, linking together software and data repositories, toolchains, workflows and outputs, providing a seamless automated infrastructure for the verification and validation of scientific models and in particular, performance benchmarks.

cs.CE↗

arXiv2014

"Can I Implement Your Algorithm?": A Model for Reproducible Research Software

The reproduction and replication of novel results has become a major issue for a number of scientific disciplines. In computer science and related computational disciplines such as systems biology, the issues closely revolve around the ability to implement novel algorithms and approaches. Taking an approach from the literature and applying it to a new codebase frequently requires local knowledge missing from the published manuscripts and project websites. Alongside this issue, benchmarking, and the development of fair --- and widely available --- benchmark sets present another barrier. In this paper, we outline several suggestions to address these issues, driven by specific examples from a range of scientific domains. Finally, based on these suggestions, we propose a new open platform for scientific software development which effectively isolates specific dependencies from the individual researcher and their workstation and allows faster, more powerful sharing of the results of scientific software engineering.

cs.SE↗