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arXiv · 1902.05883

Global Perturbation of Initial Geometry in a Biomechanical Model of Cortical Morphogenesis

Amine Bohi·Xiaoyu Wang·Mariam Al Harrach·Mickael Dinomais·François Rousseau·Julien Lefèvre
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Abstract

Cortical folding pattern is a main characteristic of the geometry of the human brain which is formed by gyri (ridges) and sulci (grooves). Several biological hypotheses have suggested different mechanisms that attempt to explain the development of cortical folding and its abnormal evolutions. Based on these hypotheses, biomechanical models of cortical folding have been proposed. In this work, we compare biomechanical simulations for several initial conditions by using an adaptive spherical parameterization approach. Our approach allows us to study and explore one of the most potential sources of reproducible cortical folding pattern: the specification of initial geometry of the brain.

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Amine Bohi, Xiaoyu Wang, Mariam Al Harrach, Mickael Dinomais, François Rousseau, Julien Lefèvre. 2019-02-11. Global Perturbation of Initial Geometry in a Biomechanical Model of Cortical Morphogenesis. https://arxiv.org/abs/1902.05883

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