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arXiv · 1903.11372

Jaccard/Tanimoto similarity test and estimation methods

Neo Christopher Chung·Błażej Miasojedow·Michał Startek·Anna Gambin
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Abstract

Binary data are used in a broad area of biological sciences. Using binary presence-absence data, we can evaluate species co-occurrences that help elucidate relationships among organisms and environments. To summarize similarity between occurrences of species, we routinely use the Jaccard/Tanimoto coefficient, which is the ratio of their intersection to their union. It is natural, then, to identify statistically significant Jaccard/Tanimoto coefficients, which suggest non-random co-occurrences of species. However, statistical hypothesis testing using this similarity coefficient has been seldom used or studied. We introduce a hypothesis test for similarity for biological presence-absence data, using the Jaccard/Tanimoto coefficient. Several key improvements are presented including unbiased estimation of expectation and centered Jaccard/Tanimoto coefficients, that account for occurrence probabilities. We derived the exact and asymptotic solutions and developed the bootstrap and measurement concentration algorithms to compute statistical significance of binary similarity. Comprehensive simulation studies demonstrate that our proposed methods produce accurate p-values and false discovery rates. The proposed estimation methods are orders of magnitude faster than the exact solution. The proposed methods are implemented in an open source R package called jaccard (https://cran.r-project.org/package=jaccard). We introduce a suite of statistical methods for the Jaccard/Tanimoto similarity coefficient, that enable straightforward incorporation of probabilistic measures in analysis for species co-occurrences. Due to their generality, the proposed methods and implementations are applicable to a wide range of binary data arising from genomics, biochemistry, and other areas of science.

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Neo Christopher Chung, Błażej Miasojedow, Michał Startek, Anna Gambin. 2019-03-27. Jaccard/Tanimoto similarity test and estimation methods. https://doi.org/10.1186/s12859-019-3118-5

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