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arXiv · 1906.11398

Increasing signal amplitude in electrical impedance tomography of neural activity using a parallel resistor inductor capacitor (RLC) circuit

James Hope·Zaid Aqrawe·Marshall Lim·Frederique Vanholsbeeck·Andrew McDaid
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Abstract

Objective: To increase the impedance signal amplitude produced during neural activity using a novel approach of implementing a parallel resistor inductor capacitor (RLC) circuit across the current source used in electrical impedance tomography (EIT) of peripheral nerve. Approach: Experiments were performed in vitro on sciatic nerve of Sprague-Dawley rats. Design of the RLC circuit was performed in electrical circuit modelling software, aided by in vitro impedance measurements on nerve and nerve cuff in the range 5 Hz to 50 kHz. Main results: The frequency range 17 +/- 1 kHz was selected for the RLC experiment. The RLC experiment was performed on four subjects using an RLC circuit designed to produce a resonant frequency of 17 kHz with a bandwidth of 3.6 kHz, and containing a 22 mH inductive element and a 3.45 nF capacitive element. With the RLC circuit connected, relative increases in the impedance signal (+/- 3sig noise) of 44 % (+/-15 %), 33 % (+/-30 %), 37 % (+/-8.6 %), and 16 % (+/-19 %) were produced. Significance: The increase in impedance signal amplitude at high frequencies, generated by the novel implementation of a parallel RLC circuit across the drive current, improves spatial resolution by increasing the number of parallel drive currents which can be implemented in a frequency division multiplexed (FDM) EIT system, and aids the long term goal of a real-time FDM EIT system by reducing the need for ensemble averaging.

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James Hope, Zaid Aqrawe, Marshall Lim, Frederique Vanholsbeeck, Andrew McDaid. 2019-06-27. Increasing signal amplitude in electrical impedance tomography of neural activity using a parallel resistor inductor capacitor (RLC) circuit. https://doi.org/10.1088/1741-2552/ab462b

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