A fast full-wave solver for trans-abdominal high-intensity focused ultrasound treatment planning

Abstract

High-intensity focused ultrasound (HIFU) is a promising treatment modality for the non-invasive ablation of pathogenic tissue in many organs. Optimal treatment planning strategies based on high-performance computing methods are expected to form a vital component of a successful clinical outcome in which healthy tissue is preserved and accurate focusing achieved. The practical application of the algorithms informing these strategies depends on the ability to produce fast and accurate full-wave patient-specific simulations, with minimal computational overheads. For realistic clinical scenarios, all simulation methods which employ volumetric meshes require several hours or days to run on a computer cluster. The boundary element method (BEM) is an effective approach for modelling the wave field because only the boundaries of the hard and soft tissue regions require discretisation. A multiple-domain BEM formulation with a novel preconditioner for solving the Helmholtz transmission problem (HTP) is presented in this paper. Numerical experiments are performed to solve HTP in multiple domains comprising: i) human ribs, an abdominal fat layer and liver tissue, ii) a human kidney and a perinephric fat layer, exposed to the acoustic field generated by a HIFU array transducer. The time required to solve the equations associated with these problems on a single workstation is of the order of minutes. These results demonstrate the great potential of this new BEM formulation for rapid and accurate HIFU treatment planning.