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arXiv · 2006.08447

Characterization of SARS-CoV-2 Dynamics in the Host

Pablo Abuin·Alejandro Anderson·Antonio Ferramosca·Esteban A. Hernandez-Vargas·Alejandro H. Gonzalez
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Abstract

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication cycle. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are properly characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such a regions, formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, such conditions are relevant to tailor future antiviral treatments. Simulation results show the potential benefits of the aforementioned system characterization.

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Pablo Abuin, Alejandro Anderson, Antonio Ferramosca, Esteban A. Hernandez-Vargas, Alejandro H. Gonzalez. 2020-06-15. Characterization of SARS-CoV-2 Dynamics in the Host. https://arxiv.org/abs/2006.08447

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