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Esteban A. Hernandez-Vargas

Publications and source records attributed to Esteban A. Hernandez-Vargas.

6 recordsLinked to original sources

A Control-Theoretic Approach for Resource-Aware Consensus in Multi-Agent AI

Large language model multi-agent systems (LLM-MAS) rely on inter-agent communication to solve complex reasoning tasks, yet rigorous guarantees relating consensus performance to computational resources remain limited. Here, we present a novel way to characterize collective belief dynamics as a discrete-time switched system in which communication topologies have distinct consensus-contraction rates and token costs. By augmenting the belief dynamics with the remaining computational budget, we define a consensus safe set that jointly captures agreement and resource feasibility. We derive explicit bounds on consensus time and token expenditure and construct a consensus-budget certificate region guaranteeing finite-time convergence without resource exhaustion. We further establish conditions under which adaptive topology switching achieves a trade-off between convergence speed and communication cost relative to fixed-topology strategies. Numerical experiments and live LLM-MAS deployments show the predicted consensus-cost trade-offs, demonstrating how control-theoretic certificates can enable resource-aware coordination in AI systems.

math.OC↗

Certifying Set Attractivity for Discrete-Time Uncertain Nonlinear Switched Systems

We introduce a new class of functions, called Attractivity Guarantee (AG)-functions, to certify the attractivity of sets for uncertain nonlinear switched systems in discrete time. The existence of an AG-function associated with a set guarantees the robust local attractivity of that set under the system dynamics. We propose a constructive method for obtaining piecewise-continuous AG-functions based on contractive sets for the system, and show that the existence of a robust control contractive set for the dynamics implies the existence of an appropriate AG-function, and hence the robust local attractivity of the set itself. We illustrate the proposed framework through examples that elucidate the theoretical concepts, and through the case study of a nonlinear switched system modelling antimicrobial resistance, which highlights the practical relevance of the approach to the analysis of biological systems.

eess.SY↗

Optimal control strategies to tailor antivirals for acute infectious diseases in the host

Several mathematical models in SARS-CoV-2 have shown how target-cell model can help to understand the spread of the virus in the host and how potential candidates of antiviral treatments can help to control the virus. Concepts as equilibrium and stability show to be crucial to qualitatively determine the best alternatives to schedule drugs, according to effectivity in inhibiting the virus infection and replication rates. Important biological events such as rebounds of the infections (when antivirals are incorrectly interrupted) can also be explained by means of a dynamic study of the target-cell model. In this work, a full characterization of the dynamical behavior of the target-cell models under control actions is made and, based on this characterization, the optimal fixed-dose antiviral schedule that produces the smallest amount of dead cells (without viral load rebounds) is computed. Several simulation results - performed by considering real patient data - show the potential benefits of both, the model characterization and the control strategy.

math.OC↗

Dynamical Characterization of Antiviral Effects in COVID-19

Mathematical models describing SARS-CoV-2 dynamics and the corresponding immune responses in patients with COVID-19 can be critical to evaluate possible clinical outcomes of antiviral treatments. In this work, based on the concept of virus spreadability in the host, antiviral effectiveness thresholds are determined to establish whether or not a treatment will be able to clear the infection. In addition, the virus dynamic in the host -- including the time-to-peak and the final monotonically decreasing behavior -- is chracterized as a function of the treatment initial time. Simulation results, based on nine real patient data, show the potential clinical benefits of a treatment classification according to patient critical parameters. This study is aimed at paving the way for the different antivirals being developed to tackle SARS-CoV-2.

math.DS↗

Characterization of SARS-CoV-2 Dynamics in the Host

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication cycle. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are properly characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such a regions, formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, such conditions are relevant to tailor future antiviral treatments. Simulation results show the potential benefits of the aforementioned system characterization.

math.DS↗

Towards Modeling HIV Long Term Behavior

The precise mechanism that causes HIV infection to progress to AIDS is still unknown. This paper presents a mathematical model which is able to predict the entire trajectory of the HIV/AIDS dynamics, then a possible explanation for this progression is examined. A dynamical analysis of this model reveals a set of parameters which may produce two real equilibria in the model. One equilibrium is stable and represents those individuals who have been living with HIV for at least 7 to 9 years, and do not develop AIDS. The other one is unstable and represents those patients who developed AIDS in an average period of 10 years. However, further work is needed since the proposed model is sensitive to parameter variations.

q-bio.CB↗