3D diffractive imaging of nanoparticle ensembles using an X-ray laser

Kartik Ayyer; P. Lourdu Xavier; Johan Bielecki; Zhou Shen; Benedikt J. Daurer; Amit K. Samanta; Salah Awel; Richard Bean; Anton Barty; Tomas Ekeberg; Armando D. Estillore; Klaus Giewekemeyer; Mark S. Hunter; Richard A. Kirian; Henry Kirkwood; Yoonhee Kim; Jayanath Koliyadu; Holger Lange; Romain Letruin; Jannik Lübke; Andrew J. Morgan; Nils Roth; Tokushi Sato; Marcin Sikorski; Florian Schulz; John C. H. Spence; Patrik Vagovic; Tamme Wollweber; Lena Worbs; Oleksandr Yefanov; Yulong Zhuang; Filipe R. N. C. Maia; Daniel A. Horke; Jochen Küpper; N. Duane Loh; Adrian P. Mancuso; Henry N. Chapman

arXiv · 2007.13597

3D diffractive imaging of nanoparticle ensembles using an X-ray laser

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Abstract

We report the 3D structure determination of gold nanoparticles (AuNPs) by X-ray single particle imaging (SPI). Around 10 million diffraction patterns from gold nanoparticles were measured in less than 100 hours of beam time, more than 100 times the amount of data in any single prior SPI experiment, using the new capabilities of the European X-ray free electron laser which allow measurements of 1500 frames per second. A classification and structural sorting method was developed to disentangle the heterogeneity of the particles and to obtain a resolution of better than 3 nm. With these new experimental and analytical developments, we have entered a new era for the SPI method and the path towards close-to-atomic resolution imaging of biomolecules is apparent.

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Kartik Ayyer, P. Lourdu Xavier, Johan Bielecki, Zhou Shen, Benedikt J. Daurer, Amit K. Samanta, Salah Awel, Richard Bean, Anton Barty, Tomas Ekeberg, Armando D. Estillore, Klaus Giewekemeyer, Mark S. Hunter, Richard A. Kirian, Henry Kirkwood, Yoonhee Kim, Jayanath Koliyadu, Holger Lange, Romain Letruin, Jannik Lübke, Andrew J. Morgan, Nils Roth, Tokushi Sato, Marcin Sikorski, Florian Schulz, John C. H. Spence, Patrik Vagovic, Tamme Wollweber, Lena Worbs, Oleksandr Yefanov, Yulong Zhuang, Filipe R. N. C. Maia, Daniel A. Horke, Jochen Küpper, N. Duane Loh, Adrian P. Mancuso, Henry N. Chapman. 2020-07-17. 3D diffractive imaging of nanoparticle ensembles using an X-ray laser. https://arxiv.org/abs/2007.13597

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