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arXiv · 2008.11718

Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

Ville-Pekka Seppä·Javier Gracia-Tabuenca·Anne Kotaniemi-Syrjänen·Kristiina Malmström·Anton Hult·Anna Pelkonen·Mika J. Mäkelä·Jari Viik·L. Pekka Malmberg
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Abstract

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

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Ville-Pekka Seppä, Javier Gracia-Tabuenca, Anne Kotaniemi-Syrjänen, Kristiina Malmström, Anton Hult, Anna Pelkonen, Mika J. Mäkelä, Jari Viik, L. Pekka Malmberg. 2020-08-26. Expiratory variability index (EVI) is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms. https://arxiv.org/abs/2008.11718

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